Muscleblind-Like 2 (Drosophila) (MBNL2) ELISA试剂盒

MBNL2 is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. 再加上,我们可以发MBNL2 抗体 (31)MBNL2 蛋白 (6)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
小鼠 MBNL2 MBNL2 105559 Q8C181
 MBNL2 MBNL2 10150 Q5VZF2
大鼠 MBNL2 MBNL2 680445 F2Z3T4
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适于 MBNL2 相互作用对的更多 ELISA 试剂盒

Mouse (Murine) Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. Mbnl1 (显示 MBNL1 ELISA试剂盒)(+/-); Mbnl2(+/-) knockout mice with myotonic dystrophy presented with clinical myofibril ultrastructural abnormality and cardiac arrhythmias.

  2. Depletion of Mbnl1 (显示 MBNL1 ELISA试剂盒) and/or Mbnl2 reduced localization of hundreds of transcripts, implicating Mbnls in localization of mRNAs to neurites

  3. Sense DMPK (显示 DMPK ELISA试剂盒) RNA foci clearly co-localize with MBNL1 (显示 MBNL1 ELISA试剂盒) and MBNL2 proteins and accumulate in myotonic dystrophy 1 tissues during development.

  4. depletion of Mbnl (显示 MBNL1 ELISA试剂盒) proteins in mouse embryo fibroblasts leads to misregulation of thousands of alternative polyadenylation events.

  5. consistent with a central and negative regulatory role for MBNL (显示 MBNL1 ELISA试剂盒) proteins in pluripotency, their knockdown significantly enhances the expression of key pluripotency genes and the formation of induced pluripotent stem cells during somatic cell reprogramming

  6. This analysis identified several hundred splicing events whose regulation depended on Mbnl (显示 MBNL1 ELISA试剂盒) function in a pattern indicating functional interchangeability between Mbnl1 (显示 MBNL1 ELISA试剂盒) and Mbnl2.

  7. We propose that major pathological features of the myotonic dystrophy brain result from disruption of the MBNL2-mediated developmental splicing program

  8. Conserved developmental stage- and tissue-specific alternative splicing of MBNL (显示 MBNL1 ELISA试剂盒) transcripts is an important mechanism by which MBNL (显示 MBNL1 ELISA试剂盒) activity is regulated during embryonic development.

  9. The authors propose that expanded CTG DNA repeats cause two separate effects: loss of Mbnl1 (显示 MBNL1 ELISA试剂盒) function (disrupting splicing) and loss of another function that disrupts extracellular matrix mRNA regulation, possibly mediated by Mbnl2.

  10. MBNL2 contribute to the pathogenesis of myotonic dystrophy.

Zebrafish Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. MBNL2 in splicing regulation of specific transcripts, which, when altered, contributes to the myotonic dystrophy phenotype.

Human Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. Sense DMPK (显示 DMPK ELISA试剂盒) RNA foci clearly co-localize with MBNL1 (显示 MBNL1 ELISA试剂盒) and MBNL2 proteins and accumulate in myotonic dystrophy 1 tissues during development.

  2. both MBNL1 and MBNL2 are involved in the regulation of Tau exon 2 splicing and the mis-splicing of Tau in DM1 is due to the combined inactivation of both

  3. consistent with a central and negative regulatory role for MBNL (显示 MBNL1 ELISA试剂盒) proteins in pluripotency, their knockdown significantly enhances the expression of key pluripotency genes and the formation of induced pluripotent stem cells during somatic cell reprogramming

  4. We propose that major pathological features of the myotonic dystrophy brain result from disruption of the MBNL2-mediated developmental splicing program

  5. MBNL (显示 MBNL1 ELISA试剂盒) proteins promote opposite splicing patterns for cardiac troponin T (显示 TNNT2 ELISA试剂盒) and insulin receptor (显示 INSR ELISA试剂盒) alternative exons

  6. MBNL1 (显示 MBNL1 ELISA试剂盒) and MBNL2 always co-distributed. Functional differences between MBNL1 (显示 MBNL1 ELISA试剂盒) and MBNL2 have not yet been found

  7. solution structures of both tandem zinc finger (TZF) motifs, TZF12 (comprising ZF1 (显示 PRMT1 ELISA试剂盒) and ZF2 (显示 ZNF274 ELISA试剂盒)) and TZF34 (ZF3 and ZF4), in MBNL2

MBNL2 抗原简介

Antigen Summary

This gene is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. This gene encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined.

Gene names and symbols associated with MBNL2

  • muscleblind like splicing factor 2 (Mbnl2) 抗体
  • muscleblind-like splicing regulator 2 (mbnl2) 抗体
  • muscleblind like splicing regulator 2 (MBNL2) 抗体
  • muscleblind-like splicing regulator 2 (Mbnl2) 抗体
  • 1110002M11Rik 抗体
  • AI047808 抗体
  • AI837313 抗体
  • AI849185 抗体
  • AL118326 抗体
  • MBLL 抗体
  • MBLL39 抗体
  • mKIAA4072 抗体
  • PRO2032 抗体
  • R75232 抗体
  • wu:fj89c04 抗体

Protein level used designations for MBNL2

muscleblind-like protein 2 , fj89c04 , muscleblind-like 2 , muscleblind-like protein 1 , muscleblind-like protein-like 39

GENE ID SPECIES
105559 Mus musculus
560384 Danio rerio
418784 Gallus gallus
527679 Bos taurus
10150 Homo sapiens
612815 Canis lupus familiaris
680445 Rattus norvegicus
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