anti-Muscleblind-Like 2 (Drosophila) (MBNL2) 抗体

MBNL2 is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. 再加上,我们可以发MBNL2 蛋白 (6)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
MBNL2 105559 Q8C181
MBNL2 10150 Q5VZF2
MBNL2 680445 F2Z3T4
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antibodies-online.cn销售最多的anti-MBNL2 抗体

Showing 10 out of 31 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB <b>WB Suggested Anti-MBNL2 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>Human brain 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 EIA, FACS, IHC (p), WB Flow cytometric analysis of Hela cells using MBNL2 Antibody (C-term) Cat.-No AP52623PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue reacted with MBNL2 Antibody (C-term) followed which was peroxidase conjugated to the secondary antibody and followed by AB staining. 0.4 mL Log in to see 6至8个工作日
$390.50
详细
非结合性 FACS, IHC (p), WB MBNL2 Antibody (C-term)  western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the MBNL2 antibody detected the MBNL2 protein (arrow). MBNL2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MBNL2 Antibody (C-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10至11个工作日
$324.50
详细
非结合性 IHC, IHC (p) Immunohistochemistry-Paraffin: MBNL2 Antibody [NBP2-43638] - Analysis of human colon carcinoma. MBNL2 antibody dilution: 1:500. Immunohistochemistry-Paraffin: MBNL2 Antibody [NBP2-43638] - Analysis of mouse liver. MBNL2 antibody dilution: 1:500. 0.1 mL Log in to see 8至11个工作日
$447.56
详细
非结合性 ELISA, WB 50 μg Log in to see 2至3个工作日
$433.13
详细
Bat 非结合性 WB 50 μg Log in to see 7至9个工作日
$551.83
详细
非结合性 WB MBNL2 antibody used at 0.2-1 ug/ml to detect target protein. 50 μg Log in to see 6至8个工作日
$473.93
详细
小鼠 非结合性 IF, ELISA Detection limit for recombinant GST tagged MBNL2 is 0.03 ng/ml as a capture antibody. Immunofluorescence of monoclonal antibody to MBNL2 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 11至12个工作日
$430.00
详细
非结合性 ICC, IF Immunocytochemistry/Immunofluorescence: MBNL2 Antibody  - Staining of human cell line SK-MEL-30 shows localization to nucleoplasm. 100 μL Log in to see 10至13个工作日
$439.69
详细
非结合性 WB Western Blot: MBNL2 Antibody [NBP1-79451] - Human Fetal Heart, Antibody Dilution: 1.0 ug/ml. Western Blot: MBNL2 Antibody [NBP1-79451] - Human Brain lysate, concentration 0.2-1 ug/ml. 100 μL Log in to see 8至11个工作日
$447.56
详细

通过反应活性、应用领域、克隆类型和共轭标记 MBNL2 抗体

特性 应用范围 宿主 克隆类型 标记
Mouse (Murine) ,


Human , , ,
,
,
, , , , ,
Rat (Rattus)


更多抗MBNL2的相互作用对抗体

Mouse (Murine) Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. Mbnl1 (显示 MBNL1 抗体)(+/-); Mbnl2(+/-) knockout mice with myotonic dystrophy presented with clinical myofibril ultrastructural abnormality and cardiac arrhythmias.

  2. Depletion of Mbnl1 (显示 MBNL1 抗体) and/or Mbnl2 reduced localization of hundreds of transcripts, implicating Mbnls in localization of mRNAs to neurites

  3. Sense DMPK (显示 DMPK 抗体) RNA foci clearly co-localize with MBNL1 (显示 MBNL1 抗体) and MBNL2 proteins and accumulate in myotonic dystrophy 1 tissues during development.

  4. depletion of Mbnl (显示 MBNL1 抗体) proteins in mouse embryo fibroblasts leads to misregulation of thousands of alternative polyadenylation events.

  5. consistent with a central and negative regulatory role for MBNL (显示 MBNL1 抗体) proteins in pluripotency, their knockdown significantly enhances the expression of key pluripotency genes and the formation of induced pluripotent stem cells during somatic cell reprogramming

  6. This analysis identified several hundred splicing events whose regulation depended on Mbnl (显示 MBNL1 抗体) function in a pattern indicating functional interchangeability between Mbnl1 (显示 MBNL1 抗体) and Mbnl2.

  7. We propose that major pathological features of the myotonic dystrophy brain result from disruption of the MBNL2-mediated developmental splicing program

  8. Conserved developmental stage- and tissue-specific alternative splicing of MBNL (显示 MBNL1 抗体) transcripts is an important mechanism by which MBNL (显示 MBNL1 抗体) activity is regulated during embryonic development.

  9. The authors propose that expanded CTG DNA repeats cause two separate effects: loss of Mbnl1 (显示 MBNL1 抗体) function (disrupting splicing) and loss of another function that disrupts extracellular matrix mRNA regulation, possibly mediated by Mbnl2.

  10. MBNL2 contribute to the pathogenesis of myotonic dystrophy.

Zebrafish Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. MBNL2 in splicing regulation of specific transcripts, which, when altered, contributes to the myotonic dystrophy phenotype.

Human Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. Sense DMPK (显示 DMPK 抗体) RNA foci clearly co-localize with MBNL1 (显示 MBNL1 抗体) and MBNL2 proteins and accumulate in myotonic dystrophy 1 tissues during development.

  2. both MBNL1 and MBNL2 are involved in the regulation of Tau exon 2 splicing and the mis-splicing of Tau in DM1 is due to the combined inactivation of both

  3. consistent with a central and negative regulatory role for MBNL (显示 MBNL1 抗体) proteins in pluripotency, their knockdown significantly enhances the expression of key pluripotency genes and the formation of induced pluripotent stem cells during somatic cell reprogramming

  4. We propose that major pathological features of the myotonic dystrophy brain result from disruption of the MBNL2-mediated developmental splicing program

  5. MBNL (显示 MBNL1 抗体) proteins promote opposite splicing patterns for cardiac troponin T (显示 TNNT2 抗体) and insulin receptor (显示 INSR 抗体) alternative exons

  6. MBNL1 (显示 MBNL1 抗体) and MBNL2 always co-distributed. Functional differences between MBNL1 (显示 MBNL1 抗体) and MBNL2 have not yet been found

  7. solution structures of both tandem zinc finger (TZF (显示 Znf318 抗体)) motifs, TZF12 (comprising ZF1 (显示 PRMT1 抗体) and ZF2 (显示 ZNF274 抗体)) and TZF34 (ZF3 and ZF4), in MBNL2

MBNL2 抗原简介

蛋白简介

This gene is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. This gene encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined.

Gene names and symbols associated with MBNL2

  • muscleblind like splicing factor 2 (Mbnl2) 抗体
  • muscleblind-like splicing regulator 2 (mbnl2) 抗体
  • muscleblind like splicing regulator 2 (MBNL2) 抗体
  • muscleblind-like splicing regulator 2 (Mbnl2) 抗体
  • 1110002M11Rik 抗体
  • AI047808 抗体
  • AI837313 抗体
  • AI849185 抗体
  • AL118326 抗体
  • MBLL 抗体
  • MBLL39 抗体
  • mKIAA4072 抗体
  • PRO2032 抗体
  • R75232 抗体
  • wu:fj89c04 抗体

Protein level used designations for MBNL2

muscleblind-like protein 2 , fj89c04 , muscleblind-like 2 , muscleblind-like protein 1 , muscleblind-like protein-like 39

GENE ID SPECIES
105559 Mus musculus
560384 Danio rerio
418784 Gallus gallus
527679 Bos taurus
10150 Homo sapiens
612815 Canis lupus familiaris
680445 Rattus norvegicus
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