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MRVI1 is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). 再加上，我们可以发Murine Retrovirus Integration Site 1 Homolog 试剂盒 (3) 和 Murine Retrovirus Integration Site 1 Homolog 蛋白 (3)和数多这个蛋白质的别的产品。
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cGKIbeta signaling via IRAG is essential for regulation of smooth muscle tone and of intracellular calcium by NO and by atrial natriuretic peptide (显示 NPPA 抗体).
conclude that cGMP-dependent relaxation of hormone receptor (显示 NR4A1 抗体)-triggered smooth muscle contraction essentially depends on the interaction of cGKI (显示 PRKG1 抗体)-IRAG with IP(3)RI
Reports use of non-AUG (CUG) translation initiation codon in one of the transcript variants of MRVI1 gene in mouse and human.
In the present study we analyzed the structure and function of the human IRAG/MRVI1 gene
IRAG is required for PKG1beta-regulated cyclic calcium release during motility of osteoclasts
IRAG appears to be essentially involved in the NO/cGK (显示 PRKG1 抗体)-dependent inhibition of InsP(3)-dependent Ca(2 (显示 CA2 抗体)+)-signaling in colonic smooth muscle
cGMP-dependent protein kinase (显示 CDK7 抗体) Ibeta binds to TFII-I (显示 GTF2I 抗体) and IRAG through a common interaction motif
These findings reveal that interaction between IRAG and InsP3RI has a central role in NO/cGMP-dependent inhibition of platelet aggregation and in vivo thrombosis.
This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.
JAW1-related protein MRVI1
, inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate
, inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate
, murine retrovirus integration site 1 protein
, protein MRVI1
, retroviral integration site 1
, IP3R-associated cGMP kinase substrate
, IP3 receptor associated cGMP kinase substrate