anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 3 (MAPK8IP3) 抗体

The protein encoded by MAPK8IP3 shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. 再加上,我们可以发和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
MAPK8IP3 23162 Q9UPT6
MAPK8IP3 30957 Q9ESN9
MAPK8IP3 302983  

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产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 IF, ELISA, WB Western blot analysis of extracts from HeLa cells, using JIP3 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HeLa cells, using JIP3 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 24至29个工作日
¥3,026.87
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小鼠 山羊 非结合性 IHC (p), IHC, ELISA Immunohistochemistry-Paraffin: JNK/JIP3 Antibody [ABIN249901] - (4ug/ml) staining of paraffin embedded Mouse Brain. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. 0.1 mg Log in to see 25至31个工作日
¥3,333.96
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Cow 非结合性 WB 100 μL Log in to see 24至29个工作日
¥3,074.65
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山羊 非结合性 IHC, ELISA   100 μg Log in to see 24至29个工作日
¥9,230.97
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非结合性 ELISA, IF, IHC, WB Western Blot (WB) analysis of specific cells using JIP-3 Polyclonal Antibody. 100 μL Log in to see 34至38个工作日
¥4,371.67
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Cow 非结合性 IC, IF, IHC, WB Immunofluorescent analysis of JIP3 staining in PC12 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of JIP3 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 7至8个工作日
¥3,941.44
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小鼠 山羊 非结合性 ELISA 0.1 mg Log in to see 24至29个工作日
¥4,732.45
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非结合性 EIA, IHC (p), WB 0.1 mg Log in to see 29至35个工作日
¥3,884.46
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非结合性 IF, ELISA, WB 100 μL Log in to see 29至35个工作日
¥4,852.60
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Cow 山羊 非结合性 ELISA   100 μg Log in to see 29至35个工作日
¥6,088.05
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通过反应活性、应用领域、克隆类型和共轭标记 MAPK8IP3 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 3 抗体

  1. Human Polyclonal MAPK8IP3 Primary Antibody for IHC, ELISA - ABIN185004 : Kelkar, Gupta, Dickens, Davis: Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. in Molecular and cellular biology 2000 (PubMed)

  2. Human Polyclonal MAPK8IP3 Primary Antibody for IF, ELISA - ABIN1534197 : Martin, Han, Gordon, Terry, Prabhakar, She, Xie, Hellsten, Chan, Altherr, Couronne, Aerts, Bajorek, Black, Blumer, Branscomb, Brown, Bruno, Buckingham, Callen, Campbell, Campbell, Campbell, Caoile et al.: The sequence and analysis of duplication-rich human chromosome 16. ... in Nature 2004 (PubMed)

更多抗Mitogen-Activated Protein Kinase 8 Interacting Protein 3的相互作用对抗体

Zebrafish Mitogen-Activated Protein Kinase 8 Interacting Protein 3 (MAPK8IP3) interaction partners

  1. our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein

Human Mitogen-Activated Protein Kinase 8 Interacting Protein 3 (MAPK8IP3) interaction partners

  1. The crystal structure of an N-terminally truncated form of LZII of JIP3 alone shows an unexpected antiparallel arrangement.

  2. Results demonstrated the increased expression of JIP3 in the temporal neocortex of TLE patients and in the experimental model of epileptic seizures

  3. JSAP1 and JLP (显示 SPAG9 抗体) play critical roles in kinesin-1-dependent axonal transport

  4. The results of this study finding suggested that a model by which the self-assembly of SYD-2/Liprin (显示 PPFIA1 抗体)-alpha proteins mediated by the coiled-coil LH1 domain is one of the key steps to the accumulation of presynaptic components at nascent synaptic junctions

  5. This study demonistrated that JIP3 mediates TrkB (显示 NTRK2 抗体) axonal anterograde transport and enhances BDNF (显示 BDNF 抗体) signaling by directly bridging TrkB (显示 NTRK2 抗体) with kinesin-1.

  6. Expression of constitutively active PI3K (显示 PIK3CA 抗体) stimulated translocation of Tiam1 (显示 TIAM1 抗体) to the membrane, increased Rac1 activity, and increased wound healing of airway epithelial cells. Increased Rac1 activity resulted in increased phosphorylation of JNK1 (显示 MAPK8 抗体).

  7. demonstration that JSAP1 bound ASK1 (显示 MAP3K5 抗体) and enhanced ASK1 (显示 MAP3K5 抗体)- and H2O2-induced JNK (显示 MAPK8 抗体) activity

  8. Pressure application of 160 mmHg for 3 h produced cell proliferation and activated ERK (显示 EPHB2 抗体) and c-JUN N-terminal kinase

  9. JIP1 (显示 MAPK8IP1 抗体) and JIP3, have a cross-talk that leads to the regulation of the ASK1 (显示 MAP3K5 抗体)-SEK1 (显示 MAP2K4 抗体)-JNK (显示 MAPK8 抗体) signal during glucose deprivation; cross-talk between JIP3 and JIP1 (显示 MAPK8IP1 抗体) is mediated through SEK1 (显示 MAP2K4 抗体)-JNK2 (显示 MAPK9 抗体) and Akt1 (显示 AKT1 抗体).

  10. JSAP1.FAK (显示 PTK2 抗体) complex functions cooperatively as a scaffold for the JNK (显示 MAPK8 抗体) signaling pathway and regulator of cell migration on FN

Mouse (Murine) Mitogen-Activated Protein Kinase 8 Interacting Protein 3 (MAPK8IP3) interaction partners

  1. These results establish the critical role of JIP3-dependent axonal lysosome transport in regulating amyloidogenic amyloid precursor protein (显示 APP 抗体) processing and support a model wherein Abeta (显示 APP 抗体) production is amplified by plaque-induced axonal lysosome transport defects.

  2. Data show that c-Jun NH2-terminal kinase (JNK (显示 MAPK8 抗体))-interacting protein-3 (JIP3) participates in the migration of cortical neurons during cortical development by mediating TrkB (显示 NTRK2 抗体) receptor axonal anterograde transport.

  3. JSAP1/JIP3 and JLP (显示 SPAG9 抗体) regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration

  4. Results demonstrated the increased expression of JIP3 in the temporal neocortex of TLE patients and in the experimental model of epileptic seizures

  5. These findings reveal that JIP3 regulation of kinesin-1 motility is critical for axon elongation and regeneration.

  6. JSAP1 and JLP (显示 SPAG9 抗体), which might be paralogous to each other, are critical and functionally redundant in cytokinesis and control ARF6 (显示 ARF6 抗体) localization to the midbody by forming a tripartite complex of JSAP1/JLP (显示 SPAG9 抗体), active ARF6 (显示 ARF6 抗体), and kinesin-1.

  7. JIP3 regulates neuronal axon elongation in a kinesin- and JNK (显示 MAPK8 抗体)-dependent manner

  8. Results suggest that JSAP1 is required for the pathfinding of the developing telencephalic commissures in the early brains.

  9. syd activates kinesin heavy chain for transport & enhances its motility, increasing its velocity & run length. syd mutants binding KHC but not kinesin light chain are transported to axons & dendrites normally.

  10. The results provide evidence that ARF6 (显示 ARF6 抗体)/JIP3 signaling regulates neurite morphogenesis.

Mitogen-Activated Protein Kinase 8 Interacting Protein 3 (MAPK8IP3) 抗原简介

蛋白简介

The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Gene names and symbols associated with MAPK8IP3

  • mitogen-activated protein kinase 8 interacting protein 3 (MAPK8IP3) 抗体
  • mitogen-activated protein kinase 8 interacting protein 3 (mapk8ip3) 抗体
  • mitogen-activated protein kinase 8 interacting protein 3 (Mapk8ip3) 抗体
  • BB120594 抗体
  • D17Wsu15e 抗体
  • JIP-3 抗体
  • Jip3 抗体
  • JSAP1 抗体
  • JSAP1a 抗体
  • JSAP1b 抗体
  • JSAP1c 抗体
  • JSAP1d 抗体
  • mKIAA1066 抗体
  • syd 抗体
  • Syd2 抗体

Protein level used designations for MAPK8IP3

mitogen-activated protein kinase 8 interacting protein 3 , C-Jun-amino-terminal kinase-interacting protein 3 , JNK-interacting protein 3 , jip3 , c-Jun-amino-terminal kinase-interacting protein 3-like , C-jun-amino-terminal kinase interacting protein 3 , JIP-3 , JNK MAP kinase scaffold protein 3 , JNK/SAPK-associated protein-1 , JNK/stress-activated protein kinase-associated protein 1 , homolog of Drosophila Sunday driver 2 , mitogen-activated protein kinase 8-interacting protein 3 , JNK/SAPK-associated protein 1 , JNK/SAPK-associated protein 1c , JUN/SAPK-associated protein 1 , c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 , mitogen activated protein kinase 8 interacting protein 3 , sunday driver 2

GENE ID SPECIES
426986 Gallus gallus
537598 Bos taurus
702388 Macaca mulatta
100067809 Equus caballus
100227405 Taeniopygia guttata
100318355 Danio rerio
100521718 Sus scrofa
23162 Homo sapiens
30957 Mus musculus
302983 Rattus norvegicus
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