anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) 抗体

MAPK8IP1 encodes a regulator of the pancreatic beta-cell function. 再加上,我们可以发MAPK8IP1 蛋白 (4)MAPK8IP1 试剂盒 (2)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
MAPK8IP1 19099 Q9WVI9
MAPK8IP1 116457 Q9R237
MAPK8IP1 9479 Q9UQF2

antibodies-online.cn销售最多的anti-MAPK8IP1 抗体

Showing 10 out of 75 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 FACS, IF, IHC (p), WB Western blot analysis of JIP1 Antibody (C-term) (ABIN652961) in MCF-7 cell line lysates (35 µg/lane). JIP1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with JIP1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 5至8个工作日
¥2,325.14
详细
非结合性 IF, ELISA, WB Western blot analysis of extracts from COLO205 cells treated with Serum 20% 15', using JIP1 (Phospho-Thr103) Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of NIH-3T3 cells, using JIP1 (Phospho-Thr103) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 24至29个工作日
¥3,026.87
详细
小鼠 小鼠 非结合性 FM, WB Western blot analysis of JIP-1 on a mouse cerebellum lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the mouse anti- JIP-1 antibody. 50 μg Log in to see 24至30个工作日
¥1,258.37
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非结合性 IF, IHC, ELISA, WB Western blot analysis of extracts from COLO205 cells, treated with Serum 20% 15', using JIP1 (Ab-103) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using JIP1 (Ab-103) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 24至29个工作日
¥3,026.87
详细
非结合性 WB Western blot analysis of extract of various cells, using MAPK8IP1 antibody. 100 μL Log in to see 34至38个工作日
¥2,882.69
详细
非结合性 WB Western blot analysis of JIP-1 in Jurkat cell lysate (Lane 1) mouse intestine (Lane 2) and rat kidney (Lane 3) tissue lysates. 100 μg Log in to see 24至29个工作日
¥3,240.37
详细
非结合性 ELISA, IF, IHC, WB 100 μL Log in to see 34至38个工作日
¥4,371.67
详细
非结合性 ELISA, IF, IHC, WB Western Blot (WB) analysis of specific cells using JIP-1 Polyclonal Antibody. 100 μL Log in to see 34至38个工作日
¥4,371.67
详细
非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-MAPK8IP1 Polyclonal Antibody, Unconjugated (ABIN716441) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 5至7个工作日
¥2,610.23
详细
非结合性 IHC (p), WB WB Image Sample(30 ug whole cell lysate) A:Hep G2 , 7.5% SDS PAGE antibody diluted at 1:1000 IHC-P Image JIP1 antibody detects JIP1 protein at cytoplasm on mouse brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse brain. JIP1 antibody , diluted at 1:500. 100 μL Log in to see 23至28个工作日
¥9,012.09
详细

通过反应活性、应用领域、克隆类型和共轭标记 MAPK8IP1 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-MAPK8IP1 抗体

  1. Mouse (Murine) Monoclonal MAPK8IP1 Primary Antibody for FM, WB - ABIN968696 : Bonny, Nicod, Waeber: IB1, a JIP-1-related nuclear protein present in insulin-secreting cells. in The Journal of biological chemistry 1998 (PubMed)
    Show all 3 Pubmed References

  2. Mouse (Murine) Monoclonal MAPK8IP1 Primary Antibody for FM, WB - ABIN968697 : Dickens, Rogers, Cavanagh, Raitano, Xia, Halpern, Greenberg, Sawyers, Davis: A cytoplasmic inhibitor of the JNK signal transduction pathway. in Science (New York, N.Y.) 1997 (PubMed)
    Show all 3 Pubmed References

更多抗MAPK8IP1的相互作用对抗体

Mouse (Murine) Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) interaction partners

  1. It mediates Alzheimer-disease like pathologies in AICD-Tg mice and that JNK (显示 MAPK8 抗体) signaling may contribute to amyloid-independent mechanisms of AD pathogenesis.

  2. Enhanced fast-velocity and efficient high-frequency APP (显示 APP 抗体) anterograde transport observed in neurons are mediated by novel roles of JIP1b.

  3. a simple yet modular mechanism for JIP1 scaffold assembly in mammals

  4. There is a collaborative relationship between JIP1 and AKT (显示 AKT1 抗体) that is required for axon growth and can be regulated by changes in neuronal activity.

  5. identify plenty of SH3 (POSH (显示 SH3RF1 抗体)) and JNK-interacting protein 1 (JIP-1) as a multiprotein scaffold network for TCR-mediated JNK1 (显示 MAPK8 抗体) activation in CD8 (显示 CD8A 抗体)(+) T cells.

  6. The phosphorylation of S421 of JIP1 serves as a molecular switch to regulate the direction of APP (显示 APP 抗体) transport in neurons.

  7. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 (显示 MAP3K11 抗体) interaction with JIP1 scaffold protein (显示 HOMER1 抗体) in cytokine-induced pancreatic beta cell death

  8. JIP1 forms a trimetric complex with RBP-Jk (显示 RBPJ 抗体) and Notch1 (显示 NOTCH1 抗体)-IC, prevents physical association between Notch1 (显示 NOTCH1 抗体)-IC and RBP-Jk (显示 RBPJ 抗体), sequesters RBP-JK (显示 RBPJ 抗体) in the cytoplasm, and suppresses the Notch1 (显示 NOTCH1 抗体) signaling pathway.

  9. Data suggest that JIP1-mediated JNK (显示 MAPK8 抗体) activation plays a critical role in metabolic stress regulation of the JNK (显示 MAPK8 抗体) signaling pathway.

  10. JIP1b can directly modulate APP (显示 APP 抗体) metabolism by interacting with the APP (显示 APP 抗体) cytoplasmic domain, independent of its regulation of the JNK (显示 MAPK8 抗体) signaling cascade.

Human Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) interaction partners

  1. All binary complexes (KLC1 (显示 KLC1 抗体):APP (显示 APP 抗体), KLC1 (显示 KLC1 抗体):JIP1, and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 (显示 KLC1 抗体) and JIP1 may take part in APP (显示 APP 抗体) transport in Alzheimer's disease patients.

  2. analysis of the role of JIP1 in APP (显示 APP 抗体) transport; knockdown of JIP1 did not affect either amyloid precursor protein (显示 APP 抗体) transport or amyloid-beta peptide production

  3. Data show that small GTPase (显示 RACGAP1 抗体) RALA (显示 rala 抗体) regulates formation of a JIP1 (C-Jun (显示 JUN 抗体)-amino-terminal-interacting protein 1) scaffold complex to propagate JNK (显示 MAPK8 抗体) signaling toward FOXO4 (显示 FOXO4 抗体) (forkhead box O (显示 FOXO 抗体) transcription factor) in response to reactive oxygen species (ROS (显示 ROS1 抗体)).

  4. In resected pancreatic cancer, carriers of a minor allele for rs3824872 (MAPK8IP1) were associated with a survival advantage compared with noncarriers with an additional 2-year survival if both minor alleles were present.

  5. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 (显示 MAP3K11 抗体) interaction with JIP1 scaffold protein (显示 HOMER1 抗体) in cytokine-induced pancreatic beta cell death

  6. Data suggest that caspase 3 (显示 CASP3 抗体)-mediated cleavage of JIP1 scaffold proteins may represent an important mechanism for modulation of JNK (显示 MAPK8 抗体) signalling during apoptotic cell death.

  7. Data show that mechanical stress of urothelial cells activates in vivo JNK (显示 MAPK8 抗体), as a consequence of a regulated expression of IB1/JIP-1, and that urothelial connexin 26 (显示 GJB2 抗体) may be directly regulated by the AP-1 (显示 FOSB 抗体) complex.

  8. results suggest that JIP (显示 SMAD4 抗体)-1b may function as a protein linking the kinesin-I motor protein to the cargo receptor, APP (显示 APP 抗体), and that the JNK (显示 MAPK8 抗体) signaling pathway may regulate the phosphorylation of this cargo protein through the JIP (显示 SMAD4 抗体)-1b scaffold

  9. JIP1 may act as an Akt1 (显示 AKT1 抗体) scaffold, which regulates the enzymatic activity of Akt1 (显示 AKT1 抗体) and can exert signaling effects independent of JNK (显示 MAPK8 抗体) activity

  10. JIP-1 protein may regulate kinesin-I-dependent neuronal AbetaPP transport, which controls AbetaPP processing

MAPK8IP1 抗原简介

蛋白简介

This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

Gene names and symbols associated with MAPK8IP1

  • mitogen-activated protein kinase 8 interacting protein 1 (MAPK8IP1) 抗体
  • mitogen-activated protein kinase 8 interacting protein 1 (LOC100344706) 抗体
  • mitogen-activated protein kinase 8 interacting protein 1 (Mapk8ip1) 抗体
  • IB1 抗体
  • Jip-1 抗体
  • JIP1 抗体
  • Mapk8ip 抗体
  • mjip-2a 抗体
  • PRKM8IP 抗体
  • Skip 抗体

Protein level used designations for MAPK8IP1

mitogen-activated protein kinase 8 interacting protein 1 , c-Jun-amino-terminal kinase-interacting protein 1-like , C-Jun-amino-terminal kinase-interacting protein 1 , IB-1 , JNK MAP kinase scaffold protein 1 , JNK-interacting protein 1 , islet-brain-1 , mitogen activated protein kinase 8 interacting protein 1 , mitogen-activated protein kinase 8-interacting protein 1 , protein kinase, mitogen-activated 8 interacting protein , JIP-1-related protein , JRP , mitogen activated protein kinase 8 interacting protein , PRKM8 interacting protein , islet-brain 1 , islet brain 1

GENE ID SPECIES
423202 Gallus gallus
100344706 Oryctolagus cuniculus
100473891 Ailuropoda melanoleuca
19099 Mus musculus
116457 Rattus norvegicus
9479 Homo sapiens
483640 Canis lupus familiaris
524806 Bos taurus
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