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activity; localization, and function is regulated by the C-terminal tail. 再加上，我们可以发Mitogen-Activated Protein Kinase 15 试剂盒 (12) 和 Mitogen-Activated Protein Kinase 15 蛋白 (8)和数多这个蛋白质的别的产品。
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Human Polyclonal MAPK15 Primary Antibody for IHC (p), WB - ABIN391796
Groehler, Lannigan: A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA. in The Journal of cell biology 2010
CapZIP (显示 RCSD1 抗体), which has been shown to regulate ciliogenesis, is an ERK7 substrate, and that Dishevelled (显示 DVL2 抗体), which has also been shown to regulate ciliogenesis, facilitates ERK7 phosphorylation of CapZIP (显示 RCSD1 抗体) through binding to both ERK7 and CapZIP (显示 RCSD1 抗体).
High MAPK15 expression is associated with male germ cell tumors.
In HeLa cells, phosphorylation of HuR (显示 ELAVL1 抗体) by ERK8 prevents it from binding to PDCD4 (显示 PDCD4 抗体) mRNA and allows miR (显示 MLXIP 抗体)-21-mediated degradation of PDCD4 (显示 PDCD4 抗体).
depletion of endogenous MAPK15 expression inhibited BCR (显示 BCR 抗体)-ABL1 (显示 ABL1 抗体)-dependent cell proliferation, in vitro
The present study suggests that MAPK15 overexpression may contribute to the malignant transformation of gastric mucosa by prolonging the stability of c-Jun (显示 JUN 抗体).
ERK8 appears as a constitutive brake on N-Acetylgalactosaminyltransferase (显示 B4GALNT2 抗体) relocalisation, and the loss of its expression could drive cancer aggressivity through increased cell motility.
Data suggest that the model coulb be a tool for the development of specific ERK8 kinase inhibitors.
ATG8 (显示 GABARAPL2 抗体)-like proteins (MAP1LC3B (显示 MAP1LC3B 抗体), GABARAP (显示 GABARAP 抗体) and GABARAPL1 (显示 GABARAPL1 抗体)) are novel interactors of MAPK15/ERK8, a MAP kinase (显示 MAPK1 抗体) involved in cell proliferation and transformation.
a novel function for ERK8 as a bona fide ERRalpha (显示 ESRRA 抗体) corepressor, involved in control of its cellular localization by nuclear exclusion, and suggest a key role for this MAP kinase (显示 MAPK1 抗体) in the regulation of the biological activities of this nuclear receptor.
Data show that ERK8 prevents HDM2-mediated PCNA (显示 PCNA 抗体) destruction by inhibiting the association of PCNA (显示 PCNA 抗体) with HDM2, and implicate ERK8 in the regulation of genomic stability.
Extracellular signal-regulated kinase 8-mediated c-Jun (显示 JUN 抗体) phosphorylation increases tumorigenesis of human colon cancer
Taken together, our results suggest that ERK8 plays an important role in spindle organization during mouse oocyte meiotic maturation and early embryo cleavage.
Erk8 has a role as a novel effector of RET (显示 RET 抗体)/PTC3 (显示 NCOA4 抗体) and, therefore, RET (显示 RET 抗体) biological functions
activity\; localization, and function is regulated by the C-terminal tail
mitogen-activated protein kinase 15
, extracellular signal-regulated kinase 7
, MAP kinase 15
, MAPK 15
, extracellular regulated kinase 8 delta
, extracellular signal regulated kinase 8
, extracellular signal-regulated kinase 8