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Mesp2 encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. 再加上，我们可以发Mesp2 抗体 (35) 和 Mesp2 蛋白 (2)和数多这个蛋白质的别的产品。
Studies indicate that mesodermal posterior 1 (Mesp1) and mesodermal posterior 2 (Mesp2) double-knockout embryos exhibited defective development of the embryonic mesoderm.
conclusion was supported by analyses of Mesp2 KO and Ripply1 (显示 RIPPLY1 ELISA试剂盒)/2 double KO embryos lacking rostral and caudal (显示 CAD ELISA试剂盒) properties, respectively
current observations of the spatiotemporal disorder of vertebral organogenesis in the Mesp2-null mice provide further insight into the pathogenesis of SCDO and STDO, and the physiological development of the axial skeleton
Data demonstrate that Mesp2 is a novel component involved in the suppression of Notch (显示 NOTCH1 ELISA试剂盒) target genes.
Data propose a novel function of Notch (显示 NOTCH1 ELISA试剂盒) signaling, in which a progressive oscillating wave of Notch (显示 NOTCH1 ELISA试剂盒) activity is translated into the rostral-caudal (显示 CAD ELISA试剂盒) polarity of a somite by regulating Mesp2 expression in the anterior presomitic mesoderm.
A bHLH-type transcription factor, Mesp2, plays an essential role in somite segmentation in mice.
Data describe the genetic interactions between Dll1 (显示 DLL1 ELISA试剂盒), Dll3 (显示 DLL3 ELISA试剂盒), Mesp2 and Psen1 (显示 PSEN1 ELISA试剂盒), and the roles of Dll1 (显示 DLL1 ELISA试剂盒)- and Dll3 (显示 DLL3 ELISA试剂盒)-Notch (显示 NOTCH1 ELISA试剂盒) pathways, with or without Psen1 (显示 PSEN1 ELISA试剂盒), in rostrocaudal patterning.
Mesp2 is responsible for the rostro-caudal (显示 CAD ELISA试剂盒) patterning process itself in the anterior presomitic mesoderm, via cellular interaction.
developmental protein "wavefront" is generated by suppression of Notch (显示 NOTCH1 ELISA试剂盒) activity by mesoderm posterior 2 (Mesp2) through induction of the lunatic fringe (显示 LFNG ELISA试剂盒) gene (Lfng (显示 LFNG ELISA试剂盒))
Tbx6 (显示 TBX6 ELISA试剂盒) directly binds to the Mesp2 gene upstream region and mediates Notch (显示 NOTCH1 ELISA试剂盒) signaling, and subsequent Mesp2 transcription, in the anterior presomitic mesoderm.
MESP2, HES7 and DUSP6 genes may not be involved in the etiopathogenesis of sporadic and non-syndromic CS in Chinese Han population.
Mutated MESP2 causes spondylocostal dysostosis
Mesp1 is down-regulated in the later stages of development by increasing levels of Mesp2 in the wild-type embryo.
findings suggest a founder-effect mutation in the MESP2 gene as a major cause of the classical Puerto Rican form of spondylothoracic dysostosis/Jarcho-Levin syndrome
This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02).
mesoderm posterior protein 2
, mesoderm posterior 2
, class C basic helix-loop-helix protein 6