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The protein encoded by MDC1 contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. 再加上，我们可以发MDC1 抗体 (166)和数多这个蛋白质的别的产品。
MDC1 plays a fundamentally significant role in maintenance of genomic stability through a DNA damage response-independent pathway.
MDC1 silencing enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in xenograft tumor growth inhibition.
oligomerization of MDC1 plays an important role in DDR (显示 DDR1 ELISA试剂盒) and help understand the formation of proteins complexes at the sites of DNA damage.
structural insight into MDC1-CHK2 (显示 CHEK2 ELISA试剂盒) interaction
the DNA damage response pathway centered on MDC1 triggers epigenetic silencing of sex chromosomes in germ cells
Data show that loss of Mof (显示 KAT8 ELISA试剂盒) leads to reduction of histone H4 K16 (显示 KRT16 ELISA试剂盒) acetylation, cell cycle arrest, chromosome aberration, defects in DNA damage repair, and complete loss of Mdc1 response to DNA damage.
Data show that ATM (显示 ATM ELISA试剂盒)-dependent resection at a subset of DSBs leads to ATR (显示 ATR ELISA试剂盒)-dependent Chk1 (显示 CHEK1 ELISA试剂盒) activation, and that 53BP1 (显示 TP53BP1 ELISA试剂盒)(-/-) and MDC1(-/-) cells manifest a checkpoint defect at high radiation doses.
identification and description of a functional homologue of human MDC1/ NFBD1; in response to ionizing radiation it forms foci that co-localize with the MRE11 (显示 MRE11A ELISA试剂盒)-RAD50 (显示 RAD50 ELISA试剂盒)-NBS1 (显示 NBN ELISA试剂盒) (MRN) complex and factors such as gammaH2AX (显示 H2AFX ELISA试剂盒) and 53BP1 (显示 TP53BP1 ELISA试剂盒)
MDC1, as a signal amplifier of the ATM (显示 ATM ELISA试剂盒) pathway, is vital in controlling proper DNA damage response and maintaining genomic stability.
MDC1 knockdown affected the formation of telomere dysfunction-induced foci.
ASF1a (显示 ASF1A ELISA试剂盒) promotes non-homologous end joining repair by facilitating phosphorylation of MDC1 by ATM (显示 ATM ELISA试剂盒) at double-strand breaks.
the opposing activities of RNF4 (显示 RNF4 ELISA试剂盒) and ataxin-3 (显示 ATXN3 ELISA试剂盒) consolidate robust MDC1-dependent signaling and repair ofDNA double-strand break.
NFBD1 protein is overexpressed in NPC (显示 NPC1 ELISA试剂盒) tissues and that silencing NFBD1 can inhibit cell growth, induce apoptosis, increase the production of intracellular ROS (显示 ROS1 ELISA试剂盒). NFBD1 knockdown also inhibits the tumorigenicity of NPC (显示 NPC1 ELISA试剂盒) cells in vivo.
NFBD1 knockdown improves the chemosensitivity of NPC (显示 NPC1 ELISA试剂盒) cells by inhibiting cell growth and promoting apoptosis through the impairment of DNA damage repair, suggesting NFBD1 as a novel therapeutic target for NPC (显示 NPC1 ELISA试剂盒).
knockdown of MCM2 or MCM6 could significantly inhibit foci forming of MDC1 in TE-1 nuclei in response to bleomycin-induced DNA damage (p < 0.001). This study indicates the direct interaction between MDC1 and MCMs in TE-1 nuclei.
The interaction of MDC1 with RNF8 (显示 RNF8 ELISA试剂盒), but not with ATM (显示 ATM ELISA试剂盒) requires WRAP53beta, suggesting that WRAP53beta facilitates the former interaction without altering phosphorylation of MDC1 by ATM (显示 ATM ELISA试剂盒).
MDC1 recruits TNKS1 (显示 TNKS ELISA试剂盒) and TNKS2 (显示 TNKS2 ELISA试剂盒) to DNA lesions.
we generated two HEP (显示 EPHB6 ELISA试剂盒)-2 cell lines with a stable knockdown of MDC1 or 53BP1 (显示 TP53BP1 ELISA试剂盒) with short hairpin RNA (shRNA), respectively, and investigated the effect of MDC1 and 53BP1 (显示 TP53BP1 ELISA试剂盒) on cell radiosensitivity
During replicative senescence and stress-induced premature senescence, MDC1 is downregulated by upregulating miR (显示 MLXIP ELISA试剂盒)-22.
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
mediation of DNA damage checkpoint 1
, mediator of DNA damage checkpoint protein 1
, homologue to Drosophila photoreceptor protein calphotin
, mediator of DNA damage checkpoint 1
, nuclear factor with BRCT domains 1