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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. 再加上，我们可以发MMP20 抗体 (74) 和 MMP20 蛋白 (7)和数多这个蛋白质的别的产品。
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DSPP (显示 DSPP ELISA试剂盒)-MMP20 pair may play a role in the normal turnover of cell surface proteins and/or repair of pericellular matrix proteins of the basement membranes in the metabolically active duct epithelial system of the nephrons.
Levels of matrix metalloproteinases MMP-19 (显示 MMP19 ELISA试剂盒) and MMP-20 expression are significantly increased in pancreatic ductal adenocarcinoma (PDAC).
The expression of MMP20 was lower in calcifying cystic odontogenic tumor when compared to all tumors and cysts.
The growth of choroidal neovascularization in AMD (显示 AMD1 ELISA试剂盒) would be affected by 2 genes: MMP20, a newly confirmed gene expressed in the retina, and ARMS2 (显示 ARMS2 ELISA试剂盒)/HTRA1 (显示 HTRA1 ELISA试剂盒), a well-known susceptibility gene for AMD (显示 AMD1 ELISA试剂盒).
Novel homozygous mutation MMP20 (c.1054G>A, p.Glu352Lys) genes were identified in amelogenesis imperfect consanguinity. Mutant MMP20 was expressed at a normal level but secreted only minimally with proteolytic function.
expression of MMP-20 and co-expression and potential interaction with DSPP (显示 DSPP ELISA试剂盒) in human major salivary gland tissues
In absolute mRNA levels, significant differences were found in expression of MMP2, MMP24, and MMP25 in gastric carcinoma compared with superficial gastritis.
The results identify MMP-20 as a broad activator of pro-KLKs, suggesting the potential for intersection of the KLK and MMP axes under pathological dysregulation of MMP-20 expression.
Polymorphisms of MMP7 (显示 MMP7 ELISA试剂盒) and MMP20 genes may be surrogate markers to predict long-term outcomes after kidney transplantation.
IL-2 (显示 IL2 ELISA试剂盒)-upregulated MT6 (显示 PRSS33 ELISA试剂盒) cell-surface expression correlates with CD16 (显示 CD16 ELISA试剂盒) downmodulation. MT6 (显示 PRSS33 ELISA试剂盒), sequestered in intracellular compartments in unstimulated NK cells, translocates to the effector-target cell interface of CD16 (显示 CD16 ELISA试剂盒)-mediated immunological synapses.
MMP20 in a common ancestor of tetrapods might have been recruited for the processing of AMEL (显示 AMELX ELISA试剂盒) and conserved over 350 million years of evolution.
this study shows that Mmp25-null mice exhibit a defective innate immune response characterized by low sensitivity to bacterial LPS (显示 TLR4 ELISA试剂盒), hypergammaglobulinemia, and reduced secretion of proinflammatory molecules
MMP-20 action guides the growth morphology of the forming hydroxyapatite crystals and enhances their crystallinity.
Matrix metalloproteinase-20 over-expression is detrimental to enamel development
MMP20 cleaves extracellular domains of cadherin adherens junction proteins, both E- and N-cadherin (显示 CDH2 ELISA试剂盒) transcripts are expressed at significantly higher levels in Mmp20 null mice; in Mmp20 ablated mice N-cadherin (显示 CDH2 ELISA试剂盒) expression persists during maturation stage
enamel of M180Tg/AmelxKO mice was thinner than WT, it had similar mechanical properties and decussating enamel prisms, which were abolished by the loss of MMP20 in the M180Tg/DKO mice.
MMP20 may influence ameloblast developmental progression through hydrolysis of cadherin extracellular domains with associated release of transcription factor(s).
Effect of kallikrein 4 (显示 KLK4 ELISA试剂盒) loss on enamel mineralization: comparison with mice lacking matrix metalloproteinase 20.
Runx2 (显示 RUNX2 ELISA试剂盒) regulates the expression of ODAM (显示 ODAM ELISA试剂盒) and nuclear ODAM (显示 ODAM ELISA试剂盒) serves an important regulatory function in the mineralization of enamel through the regulation of MMP-20 apart from a different, currently unidentified, function of extracellular ODAM (显示 ODAM ELISA试剂盒).
These data suggest MMP-25 is a direct transcriptional target for TGF-beta3 (显示 TGFB3 ELISA试剂盒) in mouse secondary palate development and could be a target for TGF-beta3 (显示 TGFB3 ELISA试剂盒) elsewhere as well.
expression of MMP-20 correlates with the stage-associated changes in the digestion of enamel proteins
MMP-20 is the enzyme that processes ameloblastin (显示 AMBN ELISA试剂盒) during the secretory stage of amelogenesis
MMP-20 processes dental sialophosphoprotein into smaller subunits in the dentin matrix during odontogenesis
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3.
, matrix metalloproteinase 20 (enamelysin)
, matrix metalloproteinase-20
, matrix metallopeptidase 20 (enamelysin)
, matrix metallopeptidase 25
, matrix metallopeptidase 20
, matrix metalloproteinase 20