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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. 再加上，我们可以发MMP15 抗体 (151) 和 MMP15 试剂盒 (19)和数多这个蛋白质的别的产品。
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Although neither proteinase is required for branching morphogenesis, transcriptome profiling reveals a key role for MMP14 (显示 MMP14 蛋白) and MMP15 in regulating mammary gland adipocyte differentiation. Whereas MMP14 (显示 MMP14 蛋白) promotes the generation of white fat depots crucial for energy storage, MMP15 differentially controls the formation of thermogenic brown fat.
Data indicate that Snai1 (显示 SNAI1 蛋白) is sufficient to promote mmp15 expression, cell transformation, and mesenchymal cell migration and invasion.
TCF-4 (显示 TCF4 蛋白) is a co-activator of NF-kappaB (显示 NFKB1 蛋白) p65 (显示 GORASP1 蛋白) that promotes MMP-15 transcription and potentiate the migration activity of the lung cancer cells
In conclusion, MT2-MMP is involved in gastric cancer invasion and metastasis and may serve as an independent prognostic factor for gastric cancer patients.
our data suggest that MT2-MMP expression positively involves in non-small cell lung cancer and might play an important role in promoting the tumor progression and intra-tumoral angiogenesis
HLA-G (显示 HLAG 蛋白) expression involved in tumor invasiveness or metastasis may rely on the NK cytotoxicity inhibition and induction of MMP-15 expression in ovarian cancer.
MMP-15 is up-regulated in preeclampsia, but does not cleave endoglin (显示 ENG 蛋白) to produce soluble endoglin (显示 ENG 蛋白).
MMP-15 and MMP-19 (显示 MMP19 蛋白) are upregulated during colorectal tumorigenesis
Data show that MT2-MMP was a novel hypoxia-responsive gene and was upregulated by HIF-1alpha (显示 HIF1A 蛋白) under hypoxia.
The intensity of immunochemical staining of MT2-MMP was significantly positively correlated to the intratumoral angiogenesis of esophageal cancer tissues.
MMP2 (显示 MMP2 蛋白) activity is associated with an increase in MT2-MMP expression and with lymph node metastasis.
These results indicate MT2-MMP might be involved in the cancer progression more than or equal to MT1-MMP (显示 MMP14 蛋白) independently of MMP-2 (显示 MMP2 蛋白) and MT1-MMP (显示 MMP14 蛋白).
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily\; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted.
, MT-MMP 2
, Membrane type 2-MMP
, matrix metalloproteinase 15
, matrix metalloproteinase-15
, membrane-type matrix metalloproteinase 2
, membrane-type-2 matrix metalloproteinase
, matrix metalloproteinase 15 (membrane-inserted)