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The protein encoded by MCTS1 is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. 再加上，我们可以发Malignant T Cell Amplified Sequence 1 抗体 (85) 和 Malignant T Cell Amplified Sequence 1 试剂盒 (9)和数多这个蛋白质的别的产品。
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Silencing or genetic deletion of MCT1 in vivo inhibited migration, invasion, and spontaneous metastasis.
It was concluded that both MCT1 and CAII (显示 CA2 蛋白) are involved in the homeostatic control of pH in skeletal muscle, both at rest and at the onset of exercise. The improved muscle function and resistance to fatigue in MCT1(+/-) mice remain unexplained.
MCT1 inhibition impairs proliferation of glycolytic breast cancer cells co-expressing MCT1 and MCT4 (显示 SLC16A3 蛋白) via disruption of pyruvate rather than lactate export.
This study demonstrated that MCT1 was up regulation in ipsilateral site of brain afeter cerebral ischemia.
The soleus, liver and heart were the main tissues that showed improved the MCT1 mRNA expression, indicating its important role in controlling MLSS concentration in mice.
Exercise-induced changes in tumour LDH-B (显示 LDHB 蛋白) and MCT1 expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice
Chronic lactate administration after exercise increases MCT1 protein expression, which can be involved in the regulation of the observed increase in muscle glycogen (显示 GYS1 蛋白) storage after exercise training.
This study showed that mouse MCT1, MCT2, and MCT4 (显示 SLC16A3 蛋白) are expressed in the PNS. While DRG neurons express MCT1, myelinating Schwann cells.
These data for the first time demonstrate that MCT1 is critical for regeneration of both sensory and motor axons in mice following sciatic nerve crush
Study demonstrated that PTEN loss and MCT-1 induction synergistically promoted the neoplastic multinucleation via the Src/p190B signaling activation.
Silencing or genetic deletion of MCT1 (显示 CMA1 蛋白) in vivo inhibited migration, invasion, and spontaneous metastasis.
The reversible H(+)/lactate(-) symporter MCT1 (显示 CMA1 蛋白) cotransports lactate and proton, leading to the net extrusion of lactic acid in glycolytic tumors. A model of its role in pH control in tumor cells is described. Review.
Reinitiation complexes involving initiation factors eIF2D (显示 EIF2D 蛋白), MCT-1 (显示 CMA1 蛋白), and DENR (显示 DENR 蛋白) controls the translation of a large fraction of mammalian cellular mRNAs.
Increased miR (显示 MLXIP 蛋白)-210 and concomitant decreased ISCU (显示 ISCU 蛋白) RNA levels were found in ~40% of tumors and this was significantly associated with HIF-1alpha (显示 HIF1A 蛋白) and CAIX (显示 CA9 蛋白), but not MCT1 (显示 CMA1 蛋白) or MCT4 (显示 SLC16A4 蛋白), over-expression.
Data show that metastasis-associated in colon cancer-1 (MACC1 (显示 MACC1 蛋白)) and monocarboxylate transporter 1 (MCT1) are highly expressed in gastric cancer indicating poor prognosis.
AA genotype of the MCT1 (显示 CMA1 蛋白) T1470A polymorphism is over-represented in wrestlers compared with controls and is associated with lower blood lactate concentrations after 30-s Wingate Anaerobic test and during intermittent sprint tests in Japanese wrestlers
MCT1 (显示 CMA1 蛋白) and MCT4 (显示 SLC16A4 蛋白) expression levels were associated with worse prognosis and shorter overall survival.
MCT1 (显示 CMA1 蛋白) may be acting as an uptake transporter and MCT4 (显示 SLC16A4 蛋白) as an efflux system across the basolateral membrane for ferulic acid, and that this process is stimulated by butyric acid.
After indirect co-culture, OP was increased in the BxPc-3 and Panc-1 cells; correspondingly, succinate dehydrogenase (显示 SDHA 蛋白), FH and MCT (显示 MCAT 蛋白) expression were increased. After the MCT1 (显示 CMA1 蛋白)-specific inhibitor removed 'tumor-stromal' metabolic coupling, the migration and invasion abilities of the pancreatic cancer cells were decreased.
Data suggest that inhibition of mnocarboxylate transporters MCT1 (显示 CMA1 蛋白) and MCT4 (显示 SLC16A4 蛋白) may have clinical relevance in pancreatic ductal adenocarcinoma (PDAC).
Data indicate that monocarboxylate transporters (MCTs1-4) were all found to be expressed in brains of embryos, and were localized in both neurons and astrocyte.
This study confirmed age-dependent changes of MCT1 expression in the rumen epithelium of newborn calves and showed that its expression might be affected by liquid feed type.
These findings show that MCT 1 increases with the development of rumen function and also in adult animals MCT 1 may change with the feeding.
The expression and distribution of monocarboxylate transporter 1 along the gastrointestinal tract of calves suggest it may play a role in transport of short chain fatty acids and their metabolites.
The results show that monocarboxylate transporter 1 (MCT1) is a major route for short chain fatty acids (SCFA) efflux across the basolateral membrane of bovine large intestine and that it could play a role in the regulation of intracellular pH.
Data suggest that expression of MCT1 in intestinal mucosa can be altered by diet; here, expression of MCT1 is down-regulated in colonic mucosa by high-protein diet and appears to be linked to fermentation of dietary proteins by intestinal microbes.
MCT1-mRNA showed a higher expression in the ileum; feeding inulin-coated butyrate resulted in an increased ileal surface; delivery of butyrate to the colon requires a more resistant inulin-coating.
The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.
malignant T cell-amplified sequence 1
, malignant T-cell-amplified sequence 1
, multiple copies T-cell malignancies
, multiple copies T-cell malignancies 1
, malignant T cell amplified sequence 1
, Malignant T cell amplified sequence 1-A
, malignant T cell-amplified sequence 1-A
, malignant T-cell-amplified sequence 1-A