anti-Maelstrom Spermatogenic Transposon Silencer (MAEL) 抗体

Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. 再加上,我们可以发MAEL 蛋白 (6)MAEL 试剂盒 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
MAEL 98558 Q8BVN9
MAEL 84944 Q96JY0
MAEL 364039  

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产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 EIA, WB   0.1 mg Log in to see 30至37个工作日
¥3,065.96
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非结合性 ELISA, ICC, IF, WB Immunocytochemistry/Immunofluorescence: MAEL Antibody [NBP1-77139] - Immunofluorescence of Maelstrom in HeLa cells with Maelstrom antibody at 20 ug/mL. Western Blot: MAEL Antibody [NBP1-77139] - HeLa cell lysate with MAEL antibody at 1 ug/mL. 0.1 mg Log in to see 26至33个工作日
¥3,655.56
详细
非结合性 ELISA, WB   100 μg Log in to see 29至35个工作日
¥5,401.63
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非结合性 IC, IF, ELISA, WB   100 μg Log in to see 33至42个工作日
¥5,024.20
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非结合性 ELISA, ICC, WB   100 μg Log in to see 29至34个工作日
¥3,183.45
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通过反应活性、应用领域、克隆类型和共轭标记 MAEL 抗体

特性 应用范围 宿主 克隆类型
Mouse (Murine)


Human


Rat (Rattus)


更多抗MAEL的相互作用对抗体

Mouse (Murine) Maelstrom Spermatogenic Transposon Silencer (MAEL) interaction partners

  1. MAEL HMG (显示 SSRP1 抗体)-box domain may contribute to MAEL function in selective processing of retrotransposon RNA into piRNAs.

  2. an important role for Mael in early oogenesis and during germ-cell differentiation from embryonic stem cells

  3. This study demonstrates that MAEL, a nuage component, is indispensable for the silencing of transposable elements (TEs (显示 TES 抗体)) and identifies the initiation of meiosis as an important step in (TE) control in the male germline.

Human Maelstrom Spermatogenic Transposon Silencer (MAEL) interaction partners

  1. Data suggest that overexpression of MAEL, caused by gene amplification and/or decreased miR (显示 MLXIP 抗体)-186, has a critical oncogenic role in UCB pathogenesis by downregulation of MTSS1 (显示 MTSS1 抗体).

  2. Study demonstrated that MAEL interacts with Snail (显示 SNAI1 抗体) and inhibit E-cadherin (显示 CDH1 抗体) promoter activity. MAEL is an oncogene (显示 RAB1A 抗体) that plays an important role in the development and progression of colon cancer.

  3. Immunofluorescence analysis showed that MAEL co-localizes with the stress granule marker PABPC1 (显示 PABPC1 抗体) in stress granules during oxidative stress. MAEL may be involved in miRNA-mediated gene silencing in SGs (显示 FBN1 抗体).

  4. Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt (显示 AKT1 抗体)/GSK-3beta (显示 GSK3b 抗体)/Snail (显示 SNAI1 抗体) signaling.

  5. These results suggest that MAEL is a novel cancer/testis-associated gene and is regulated by DNA methylation (显示 HELLS 抗体).

MAEL 抗原简介

蛋白简介

Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuage (By similarity).

Gene names and symbols associated with MAEL

  • maelstrom homolog (Drosophila) (Mael) 抗体
  • maelstrom homolog (Drosophila) (MAEL) 抗体
  • maelstrom spermatogenic transposon silencer (MAEL) 抗体
  • maelstrom spermatogenic transposon silencer (Mael) 抗体
  • protein maelstrom homolog (LOC100737640) 抗体
  • 4933405K18Rik 抗体
  • AU019877 抗体
  • CT128 抗体
  • RGD1309333 抗体
  • RP11-102C16.1 抗体
  • SPATA35 抗体

Protein level used designations for MAEL

protein maelstrom homolog , cancer/testis antigen 128 , maelstrom homolog , spermatogenesis associated 35

GENE ID SPECIES
98558 Mus musculus
541073 Bos taurus
100048945 Sus scrofa
84944 Homo sapiens
364039 Rattus norvegicus
100737640 Sus scrofa
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