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Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. 再加上，我们可以发MDS1 and EVI1 Complex Locus 抗体 (118) 和 MDS1 and EVI1 Complex Locus 试剂盒 (2)和数多这个蛋白质的别的产品。
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nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (显示 NOTCH1 蛋白) signaling
Prdm3 and prdm16 (显示 PRDM16 蛋白) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.
discussion of the role of RUNX1 (显示 RUNX1 蛋白) in diseases caused by their mutations or deletions (review)
Placental hematopoietic stem and progenitor cells likely arise from hematopoietic niches comprised RUNX1 (显示 RUNX1 蛋白)+ mesenchyme and vascular endothelium. Pregnancy complications that result in preterm birth differentially affect placental hematopoietic stem and progenitor cells localization and RUNX1 (显示 RUNX1 蛋白) expression
deficiency alters the expression of a crucial subset of TAL1 (显示 TAL1 蛋白)- and NOTCH1 (显示 NOTCH1 蛋白)-regulated genes, including the MYB (显示 MYB 蛋白) and MYC (显示 MYC 蛋白) oncogenes, respectively.
Findings represent the first global genome-wide study of EVI1 DNA binding associated with whole transcriptome expression analysis. Results reveal several important genes with an ETS (显示 ETS1 蛋白)-like binding motif, is involved in terminal myeloid differentiation, cell cycle regulation and apoptosis
Our findings strengthen previous data concerning RUNX1 (显示 RUNX1 蛋白) mutations in acute myeloid leukemia (显示 BCL11A 蛋白) and support the notion that RUNX1 (显示 RUNX1 蛋白) mutational status should be integrated into a diagnostic workup of acute myeloid leukemia (显示 BCL11A 蛋白).
Heterozygous germ line mutations in the RUNX1 (显示 RUNX1 蛋白) gene are responsible genetic events for FPD/AML (显示 RUNX1 蛋白).
Data suggest that RUNX1 (显示 RUNX1 蛋白) pays dual roles in normal female sexual development/maturation and tumorigenesis in female-related cancers; "alterations" in RUNX1 (显示 RUNX1 蛋白), either mutations in RUNX1 (显示 RUNX1 蛋白) gene or variations in expression of RUNX1 (显示 RUNX1 蛋白), appear to be associated with breast, ovarian, uterine, and cervical neoplasms. [REVIEW]
The E3 ubiquitin ligase (显示 MUL1 蛋白) STUB1 (显示 STUB1 蛋白) is a negative regulator of both RUNX1 (显示 RUNX1 蛋白) and RUNX1 (显示 RUNX1 蛋白)-RUNX1T1 (显示 RUNX1T1 蛋白). Activation of STUB1 (显示 STUB1 蛋白) could be a promising therapeutic strategy for RUNX1 (显示 RUNX1 蛋白)-RUNX1T1 (显示 RUNX1T1 蛋白) leukemia.
The clinical significance of ETV6 (显示 ETV6 蛋白)-RUNX1 (显示 RUNX1 蛋白).
Deliver the necessary promotional drive for the progression of ETV6 (显示 ETV6 蛋白)-RUNX1 (显示 RUNX1 蛋白)+ pre-leukaemic cells.
Gata2 (显示 GATA2 蛋白) heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice
EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.
the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (显示 CEBPA 蛋白) from EVI1-induced suppression.
Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (显示 CSF2 蛋白), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (显示 CSF2 蛋白) levels.
Survivin (显示 BIRC5 蛋白) partially regulates HSC (显示 FUT1 蛋白) function by modulating the Evi-1 transcription factor and its downstream targets
Thrombopoietin (显示 THPO 蛋白)/MPL (显示 MPL 蛋白) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.
Prdm16 (显示 PRDM16 蛋白) and Prdm3 control postnatal BAT (显示 BAAT 蛋白) identity and function.
Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.
PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (显示 MLL 蛋白)) fusion protein (MFP) leukemia
Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (显示 CEBPB 蛋白), liver inhibitory protein (LIP), induced acute myeloid leukemia (显示 BCL11A 蛋白) with short latencies in a mouse bone marow transplantation model.
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.
AML1-EVI-1 fusion protein
, MDS1 and EVI1 complex locus protein EVI1
, MDS1 and EVI1 complex locus protein MDS1
, ecotropic virus integration site 1 protein homolog
, myelodysplasia syndrome-associated protein 1
, oncogene EVI1
, zinc finger protein Evi1
, ecotropic viral integration site 1
, ecotropic virus integration site 1 protein
, myelodysplasia syndrome 1 homolog
, myelodysplasia syndrome 1 protein homolog
, PR domain containing 3
, MDS1 and EVI1 complex locus
, MDS1 and EVI1 complex locus protein EVI1-like
, MDS1 and EVI1 complex locus protein EVI1-A
, ecotropic virus integration site 1 protein homolog-A
, myelodysplasia syndrome 1-ectopic viral integration site 1