MDS1 and EVI1 Complex Locus 蛋白 (MECOM)

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. 再加上,我们可以发MDS1 and EVI1 Complex Locus 抗体 (118)MDS1 and EVI1 Complex Locus 试剂盒 (2)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
大鼠 MECOM MECOM 294924  

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MECOM 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
,
Mouse (Murine)

更多MDS1 and EVI1 Complex Locus (MECOM)互动伙伴

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (显示 NOTCH1 蛋白) signaling

  2. Prdm3 and prdm16 (显示 PRDM16 蛋白) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. these findings have identified a novel function for Runx1 (显示 RUNX1 蛋白) in sustaining normal mammary epithelial morphology and preventing epithelial-mesenchymal transition

  2. Leukaemogenesis by AML1 (显示 RUNX1 蛋白)-ETO (显示 RUNX1T1 蛋白) requires enhanced C/D box snoRNA/RNP (显示 RNPC3 蛋白) formation.

  3. The expression of EVI1 and SOX9 (显示 SOX9 蛋白) is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells. These results establish the mechanistic link between resistance to mTOR (显示 FRAP1 蛋白) inhibition and cancer metastatic potential, thus enhancing our understanding of mTOR (显示 FRAP1 蛋白) targeting failure

  4. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (显示 F2 蛋白)-activatable receptor PAR-1 (protease-activated receptor-1 (显示 F2R 蛋白)), in Runx1 (显示 RUNX1 蛋白)/Cbfb (显示 CBFB 蛋白)-deleted MLL (显示 MLL 蛋白)-AF9 (显示 MLLT3 蛋白) cells. Similar to the effect of Runx1 (显示 RUNX1 蛋白)/Cbfb (显示 CBFB 蛋白) deletion, PAR-1 (显示 MARK2 蛋白) overexpression induced CDKN1A/p21 (显示 CDKN1A 蛋白) expression and attenuated proliferation in MLL (显示 MLL 蛋白)-AF9 (显示 MLLT3 蛋白) cells

  5. EVI1 contributes to PCa (显示 FLVCR1 蛋白) progression by regulating different oncogenic functions. EVI1 regulates the PCa (显示 FLVCR1 蛋白) stem cell compartment responsible for disease initiation and also development of CRPC.

  6. oncogenic potential for EVI1 in modulating genomic stability

  7. LRG1 (显示 LRG1 蛋白) plays a crucial role in the proliferation and apoptosis of colorectal cancer (CRC (显示 CALR 蛋白)) by regulating RUNX1 (显示 RUNX1 蛋白) expression.

  8. RUNX1 (显示 RUNX1 蛋白) RNA and protein are upregulated in proliferative diabetic retinopathy and in response to high glucose in vitro. Immunohistochemical staining for RUNX1 (显示 RUNX1 蛋白) showed reactivity in vessels of patient-derived fibrovascular membranes, suggesting that RUNX1 (显示 RUNX1 蛋白) upregulation is a hallmark of aberrant retinal angiogenesis.

  9. RUNX1 (显示 RUNX1 蛋白) overexpression induced partial DNA demethylation at SPI1 (显示 SPI1 蛋白) proximal promoter.

  10. mutations in the SRSF2 (显示 SRSF2 蛋白)/ASXL1 (显示 ASXL1 蛋白)/RUNX1 (显示 RUNX1 蛋白) gene panel identified as significant prognostic markers in systemic mastocytosis

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  2. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (显示 CEBPA 蛋白) from EVI1-induced suppression.

  3. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (显示 CSF2 蛋白), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (显示 CSF2 蛋白) levels.

  4. Survivin (显示 BIRC5 蛋白) partially regulates HSC (显示 FUT1 蛋白) function by modulating the Evi-1 transcription factor and its downstream targets

  5. Thrombopoietin (显示 THPO 蛋白)/MPL (显示 MPL 蛋白) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  6. Prdm16 (显示 PRDM16 蛋白) and Prdm3 control postnatal BAT (显示 BAAT 蛋白) identity and function.

  7. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  8. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (显示 MLL 蛋白)) fusion protein (MFP) leukemia

  9. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (显示 CEBPB 蛋白), liver inhibitory protein (LIP), induced acute myeloid leukemia (显示 BCL11A 蛋白) with short latencies in a mouse bone marow transplantation model.

  10. Transient Evi1 transfection inhibited TGF-beta (显示 TGFB1 蛋白)-induced transcriptional activity and reversed the growth inhibitory effect of TGF-beta (显示 TGFB1 蛋白) in MC-26 (显示 Glycam1 蛋白) mouse colon cancer cells.

蛋白简介MDS1 and EVI1 Complex Locus (MECOM)

蛋白简介

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (mecom)
  • MDS1 and EVI1 complex locus (MECOM)
  • MDS1 and EVI1 complex locus (LOC100343228)
  • MDS1 and EVI1 complex locus (Mecom)
  • runt-related transcription factor 1 (RUNX1)
  • AML1 蛋白
  • AML1-EVI-1 蛋白
  • AMLCR1 蛋白
  • CBFA2 蛋白
  • D630039M04Rik 蛋白
  • EVI-1 蛋白
  • Evi1 蛋白
  • im:7140716 蛋白
  • Jbo 蛋白
  • Mds 蛋白
  • Mds1 蛋白
  • Mds1-Evi1 蛋白
  • PEBP2aB 蛋白
  • Prdm3 蛋白
  • Znfpr1b1 蛋白

Protein level used designations for MECOM

ecotropic viral integration site 1 , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core-binding factor, runt domain, alpha subunit 2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit

GENE ID SPECIES
497407 Danio rerio
460837 Pan troglodytes
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
2122 Homo sapiens
14013 Mus musculus
424997 Gallus gallus
488148 Canis lupus familiaris
532209 Bos taurus
294924 Rattus norvegicus
861 Homo sapiens
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