MDS1 and EVI1 Complex Locus 蛋白 (MECOM)

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. 再加上,我们可以发MDS1 and EVI1 Complex Locus 抗体 (118)MDS1 and EVI1 Complex Locus 试剂盒 (2)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
大鼠 MECOM MECOM 294924  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • 在线下订单
  • orders@antibodies-online.cn

antibodies-online.cn销售最多的MDS1 and EVI1 Complex Locus 蛋白

Showing 4 out of 8 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$12,127.90
详细
Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$12,127.90
详细
小麦胚 GST tag 10 μg Log in to see 11至12个工作日
$414.29
详细
大肠杆菌(E. Coli) 非结合性   20 μg Log in to see 2至3个工作日
$388.93
详细

MECOM 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
,
Mouse (Murine)

更多MDS1 and EVI1 Complex Locus (MECOM)互动伙伴

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Letter/Case Report: ETV6 (显示 ETV6 蛋白)/MECOM gene fusion in therapy-related acute myeloid leukemia (显示 BCL11A 蛋白) with t(3;12) and monosomy 7.

  2. These findings highlight a novel mechanism for hepatitis B virus X-induced hepatocarcinogenesis through transcription factor EVI1 and its target lncRNAs

  3. Findings represent the first global genome-wide study of EVI1 DNA binding associated with whole transcriptome expression analysis. Results reveal several important genes with an ETS (显示 ETS1 蛋白)-like binding motif, is involved in terminal myeloid differentiation, cell cycle regulation and apoptosis

  4. The expression of EVI1 and SOX9 (显示 SOX9 蛋白) is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells. These results establish the mechanistic link between resistance to mTOR (显示 FRAP1 蛋白) inhibition and cancer metastatic potential, thus enhancing our understanding of mTOR (显示 FRAP1 蛋白) targeting failure

  5. EVI1 contributes to PCa (显示 FLVCR1 蛋白) progression by regulating different oncogenic functions. EVI1 regulates the PCa (显示 FLVCR1 蛋白) stem cell compartment responsible for disease initiation and also development of CRPC.

  6. oncogenic potential for EVI1 in modulating genomic stability

  7. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  8. EVI1 overexpression alters cellular metabolism. EVI1 promotes CKMT1 (显示 CKMT1B 蛋白) expression by repressing the myeloid differentiation regulator RUNX1 (显示 RUNX1 蛋白).

  9. EVI1 transcription is directly regulated by LEF1 (显示 LEF1 蛋白)/beta-catenin (显示 CTNNB1 蛋白) complex in myeloid blast crisis of chronic myeloid leukemia (显示 BCL11A 蛋白). Loss of p53 (显示 TP53 蛋白) function as a key regulator for beta-catenin (显示 CTNNB1 蛋白)-EVI1 in myeloid blast crisis of chronic myeloid leukemia (显示 BCL11A 蛋白).

  10. we demonstrated that miR (显示 MLXIP 蛋白)-22 promoted monocyte/macrophage differentiation, and MECOM (EVI1) mRNA is a direct target of miR (显示 MLXIP 蛋白)-22 and MECOM (EVI1) functions as a negative regulator in the differentiation.The miR (显示 MLXIP 蛋白)-22-mediated MECOM degradation increased c-Jun (显示 JUN 蛋白) but decreased GATA2 (显示 GATA2 蛋白) expression, which results in increased interaction between c-Jun (显示 JUN 蛋白) and PU.1

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. These findings highlight a novel mechanism for hepatitis B virus X-induced hepatocarcinogenesis through transcription factor EVI1 and its target lncRNAs

  2. Gata2 (显示 GATA2 蛋白) heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice

  3. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  4. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (显示 CEBPA 蛋白) from EVI1-induced suppression.

  5. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (显示 CSF2 蛋白), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (显示 CSF2 蛋白) levels.

  6. Survivin (显示 BIRC5 蛋白) partially regulates HSC (显示 FUT1 蛋白) function by modulating the Evi-1 transcription factor and its downstream targets

  7. Thrombopoietin (显示 THPO 蛋白)/MPL (显示 MPL 蛋白) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  8. Prdm16 (显示 PRDM16 蛋白) and Prdm3 control postnatal BAT (显示 BAAT 蛋白) identity and function.

  9. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  10. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (显示 MLL 蛋白)) fusion protein (MFP) leukemia

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (显示 NOTCH1 蛋白) signaling

  2. Prdm3 and prdm16 (显示 PRDM16 蛋白) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Xenopus laevis MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Evi-1 (显示 RUNX1 蛋白) is detected by in situ hybridization in the pronephric tissue, the brain and in neural crest derivatives of the head and neck

蛋白简介MDS1 and EVI1 Complex Locus (MECOM)

蛋白简介

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (MECOM)
  • MDS1 and EVI1 complex locus (Mecom)
  • MDS1 and EVI1 complex locus (mecom)
  • MDS1 and EVI1 complex locus L homeolog (mecom.L)
  • AML1-EVI-1 蛋白
  • D630039M04Rik 蛋白
  • evi-1 蛋白
  • evi1 蛋白
  • im:7140716 蛋白
  • Jbo 蛋白
  • Mds 蛋白
  • Mds1 蛋白
  • Mds1-Evi1 蛋白
  • mecom 蛋白
  • mecom-a 蛋白
  • mecom-b 蛋白
  • prdm3 蛋白
  • xEvi-1 蛋白
  • Znfpr1b1 蛋白

Protein level used designations for MECOM

AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic viral integration site 1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , MDS1 and EVI1 complex locus protein EVI1-A , ecotropic virus integration site 1 protein homolog-A , myelodysplasia syndrome 1-ectopic viral integration site 1

GENE ID SPECIES
2122 Homo sapiens
424997 Gallus gallus
532209 Bos taurus
14013 Mus musculus
497407 Danio rerio
460837 Pan troglodytes
488148 Canis lupus familiaris
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
294924 Rattus norvegicus
734157 Xenopus laevis
MDS1 and EVI1 Complex Locus 蛋白 (MECOM) 精选生产商
您还需要查找其他产品吗?