MDS1 and EVI1 Complex Locus 蛋白 (MECOM)

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. 再加上,我们可以发MDS1 and EVI1 Complex Locus 抗体 (118)MDS1 and EVI1 Complex Locus 试剂盒 (2)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
大鼠 MECOM MECOM 294924  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • 在线下订单
  • orders@antibodies-online.cn

antibodies-online.cn销售最多的MDS1 and EVI1 Complex Locus 蛋白

Showing 4 out of 8 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
详细
Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
详细
小麦胚 GST tag 10 μg Log in to see 11至12个工作日
$405.71
详细
大肠杆菌(E. Coli) 非结合性   20 μg Log in to see 2至3个工作日
$388.93
详细

MECOM 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
,
Mouse (Murine)

更多MDS1 and EVI1 Complex Locus (MECOM)互动伙伴

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (显示 NOTCH1 蛋白) signaling

  2. Prdm3 and prdm16 (显示 PRDM16 蛋白) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. discussion of the role of RUNX1 (显示 RUNX1 蛋白) in diseases caused by their mutations or deletions (review)

  2. Placental hematopoietic stem and progenitor cells likely arise from hematopoietic niches comprised RUNX1 (显示 RUNX1 蛋白)+ mesenchyme and vascular endothelium. Pregnancy complications that result in preterm birth differentially affect placental hematopoietic stem and progenitor cells localization and RUNX1 (显示 RUNX1 蛋白) expression

  3. deficiency alters the expression of a crucial subset of TAL1 (显示 TAL1 蛋白)- and NOTCH1 (显示 NOTCH1 蛋白)-regulated genes, including the MYB (显示 MYB 蛋白) and MYC (显示 MYC 蛋白) oncogenes, respectively.

  4. Findings represent the first global genome-wide study of EVI1 DNA binding associated with whole transcriptome expression analysis. Results reveal several important genes with an ETS (显示 ETS1 蛋白)-like binding motif, is involved in terminal myeloid differentiation, cell cycle regulation and apoptosis

  5. Our findings strengthen previous data concerning RUNX1 (显示 RUNX1 蛋白) mutations in acute myeloid leukemia (显示 BCL11A 蛋白) and support the notion that RUNX1 (显示 RUNX1 蛋白) mutational status should be integrated into a diagnostic workup of acute myeloid leukemia (显示 BCL11A 蛋白).

  6. Heterozygous germ line mutations in the RUNX1 (显示 RUNX1 蛋白) gene are responsible genetic events for FPD/AML (显示 RUNX1 蛋白).

  7. Data suggest that RUNX1 (显示 RUNX1 蛋白) pays dual roles in normal female sexual development/maturation and tumorigenesis in female-related cancers; "alterations" in RUNX1 (显示 RUNX1 蛋白), either mutations in RUNX1 (显示 RUNX1 蛋白) gene or variations in expression of RUNX1 (显示 RUNX1 蛋白), appear to be associated with breast, ovarian, uterine, and cervical neoplasms. [REVIEW]

  8. The E3 ubiquitin ligase (显示 MUL1 蛋白) STUB1 (显示 STUB1 蛋白) is a negative regulator of both RUNX1 (显示 RUNX1 蛋白) and RUNX1 (显示 RUNX1 蛋白)-RUNX1T1 (显示 RUNX1T1 蛋白). Activation of STUB1 (显示 STUB1 蛋白) could be a promising therapeutic strategy for RUNX1 (显示 RUNX1 蛋白)-RUNX1T1 (显示 RUNX1T1 蛋白) leukemia.

  9. The clinical significance of ETV6 (显示 ETV6 蛋白)-RUNX1 (显示 RUNX1 蛋白).

  10. Deliver the necessary promotional drive for the progression of ETV6 (显示 ETV6 蛋白)-RUNX1 (显示 RUNX1 蛋白)+ pre-leukaemic cells.

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Gata2 (显示 GATA2 蛋白) heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice

  2. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  3. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (显示 CEBPA 蛋白) from EVI1-induced suppression.

  4. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (显示 CSF2 蛋白), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (显示 CSF2 蛋白) levels.

  5. Survivin (显示 BIRC5 蛋白) partially regulates HSC (显示 FUT1 蛋白) function by modulating the Evi-1 transcription factor and its downstream targets

  6. Thrombopoietin (显示 THPO 蛋白)/MPL (显示 MPL 蛋白) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  7. Prdm16 (显示 PRDM16 蛋白) and Prdm3 control postnatal BAT (显示 BAAT 蛋白) identity and function.

  8. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  9. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (显示 MLL 蛋白)) fusion protein (MFP) leukemia

  10. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (显示 CEBPB 蛋白), liver inhibitory protein (LIP), induced acute myeloid leukemia (显示 BCL11A 蛋白) with short latencies in a mouse bone marow transplantation model.

蛋白简介MDS1 and EVI1 Complex Locus (MECOM)

蛋白简介

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (MECOM)
  • MDS1 and EVI1 complex locus (Mecom)
  • MDS1 and EVI1 complex locus (mecom)
  • MDS1 and EVI1 complex locus L homeolog (mecom.L)
  • AML1-EVI-1 蛋白
  • D630039M04Rik 蛋白
  • evi-1 蛋白
  • evi1 蛋白
  • im:7140716 蛋白
  • Jbo 蛋白
  • Mds 蛋白
  • Mds1 蛋白
  • Mds1-Evi1 蛋白
  • mecom 蛋白
  • mecom-a 蛋白
  • mecom-b 蛋白
  • prdm3 蛋白
  • xEvi-1 蛋白
  • Znfpr1b1 蛋白

Protein level used designations for MECOM

AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic viral integration site 1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , MDS1 and EVI1 complex locus protein EVI1-A , ecotropic virus integration site 1 protein homolog-A , myelodysplasia syndrome 1-ectopic viral integration site 1

GENE ID SPECIES
2122 Homo sapiens
424997 Gallus gallus
532209 Bos taurus
14013 Mus musculus
497407 Danio rerio
460837 Pan troglodytes
488148 Canis lupus familiaris
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
294924 Rattus norvegicus
734157 Xenopus laevis
MDS1 and EVI1 Complex Locus 蛋白 (MECOM) 精选生产商
您还需要查找其他产品吗?