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MARK2 encodes a member of the Par-1 family of serine/threonine protein kinases. 再加上，我们可以发MAP/microtubule Affinity-Regulating Kinase 2 抗体 (96) 和 MAP/microtubule Affinity-Regulating Kinase 2 蛋白 (10)和数多这个蛋白质的别的产品。
In the modeled structure of inactive MARK2, activation segment occludes the enzyme active site and assumes a relatively stable position.
In conclusion, baicalin and DDP (显示 TIMM8A ELISA试剂盒) were synergistic at inhibiting proliferation and invasion of human lung cancer cells at appropriate dosages and incubation time in the presence or absence of DDP (显示 TIMM8A ELISA试剂盒) resistance. The attenuation of DDP (显示 TIMM8A ELISA试剂盒) resistance was associated with downregulation of MARK2 and p-Akt (显示 AKT1 ELISA试剂盒).
MARK2 plays a role in promoting malignant phenotypes of lung cancer.
Phosphorylation of RNF41 (显示 RNF41 ELISA试剂盒) by Par-1b regulates basolateral membrane targeting of laminin-111 receptors.
induces asymmetric inheritance of plasma membrane domains via LGN (显示 GPSM2 ELISA试剂盒)-dependent mitotic spindle orientation in proliferating hepatocytes
Perturbation of PAR1b and SHP2 (显示 PTPN11 ELISA试剂盒) by CagA (显示 S100A8 ELISA试剂盒) underlies the oncogenic potential of CagA (显示 S100A8 ELISA试剂盒).
The MARK2 binds to the N-terminal tail of Tau and selectively phosphorylates three major and five minor serine residues in the repeat domain and C-terminal tail.
Hepatocyte Par1b defines lumen position in concert with the position of the astral microtubule anchoring complex LGN (显示 GPSM2 ELISA试剂盒)-NuMA (显示 NUMA1 ELISA试剂盒) to yield the distinct epithelial division phenotypes.
automated image analysis of MT assembly dynamics identified MARK2 as a target regulated downstream of Rac1 that promotes oriented MT growth in the leading edge to mediate directed cell migration.
The scaffolding adaptor GAB1 interacts with two polarity proteins, PAR1 and PAR3 (显示 F2RL2 ELISA试剂盒).
data suggest ectopic PAR1 (显示 F2R ELISA试剂盒) expression is not tolerated in mouse platelets and indicate a different approach is required to develop a small animal model for the purpose of any future preclinical testing of PAR (显示 AFG3L2 ELISA试剂盒) antagonists as anti-platelet drugs
a model whereby MARK2 negatively regulates insulin (显示 INS ELISA试剂盒) sensitivity in peripheral tissue through inhibition of KSR1 (显示 KSR1 ELISA试剂盒)
ROCK1 (显示 ROCK1 ELISA试剂盒)/PAR-1b-dependent regulation of basement membrane placement is required for the coordination of tissue polarity and the elaboration of tissue structure in the developing submandibular salivary gland.
PAR1b plays a novel role in the maintenance of mature dendritic spine morphology by regulating microtubule growth and the accumulation of p140Cap (显示 SRCIN1 ELISA试剂盒) in dendritic spines.
Par-1b is a regulator of glucose metabolism and adiposity in the whole animal
Interaction of MARK2 with CaMKI (显示 CAMK1 ELISA试剂盒) results in a novel, calcium-dependent pathway that plays an important role in neuronal differentiation.
Akt (显示 AKT1 ELISA试剂盒) enhances the activity of PAR1 (显示 F2R ELISA试剂盒) to promote tau hyperphosphorylation at S262/S356, a tau species that is not recognized by the CHIP/Hsp90 (显示 HSP90 ELISA试剂盒) complex
Coreduction of MARK2 and DCX (显示 DCX ELISA试剂盒) resulted in a partial restoration of the normal neuronal migration phenotype in vivo. The kinetic behavior of the centrosomes reflected the different molecular mechanisms activated when either protein was reduced.
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene.
ELKL motif kinase 1
, PAR1 homolog b
, Ser/Thr protein kinase PAR-1B
, serine/threonine protein kinase EMK
, serine/threonine-protein kinase MARK2
, serine/threonine kinase