anti-MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) 抗体

The protein encoded by MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. 再加上,我们可以发MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) 蛋白 (8)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
MAD2L2 71890 Q9D752
MAD2L2 10459 Q9UI95
MAD2L2 313702 D3Z8D9
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antibodies-online.cn销售最多的anti-MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) 抗体

Showing 10 out of 46 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
小鼠 非结合性 IF, WB Western blot analysis of MAD2B on a K-562 cell lysate (Human bone marrow myelogenous leukemia, ATCC CCL-243). Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the mouse anti- MAD2B antibody. Immunofluorescence staining of human endothelial cells. 50 μg Log in to see 6至8个工作日
$154.07
详细
非结合性 EIA, IF, IHC (p), WB 50 μg Log in to see 6至8个工作日
$500.50
详细
非结合性 CP, IHC, ELISA, WB Affinity Purified anti-MAD2L2 antibody shows strong nuclear and cytoplasmic staining of tumor cells in cancerous human kidney tissue. Tissue was formalin-fixed and paraffin embedded. Brown color indicates presence of protein, blue color shows cell nuclei. 100 μg Log in to see 1至2个工作日
$379.00
详细
非结合性 IF, IHC (p), ELISA, WB Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with MAD2L2 antibody ABIN214364 at 10 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7至9个工作日
$451.00
详细
非结合性 WB Western blot analysis of extracts of various cells, using MAD2L2 antibody. 100 μL Log in to see 16 Days
$323.13
详细
非结合性 ELISA, ICC, IF, IHC, IHC (p), WB Western Blot: MAD2L2 Antibody [NBP1-02798] - Affinity Purified Rabbit anti-MAD2L2 was used at a 1:500 dilution to detect human MAD2L2 by western blot. Both HeLa whole cell lysate (lane 1) and nuclear lysate (lane 2) were probed using this antibody. This antibody clearly detects a ~20 kD band corresponding to human MAD2L2 (predicted molecular weight is 24 kD). Approximately 20 ug of each lysate was loaded on a 10% SDS-PAGE. Primary antibody was reacted with the membrane at room temperature for 1 h. After subsequent washing, a 1:2000 dilution of HRP conjugated Gt-a-Rabbit IgG was used for visualization. Exposure time was 30 sec. Immunohistochemistry-Paraffin: MAD2L2 Antibody [NBP1-02798] - Staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 0.05 mg Log in to see 10至13个工作日
$447.56
详细
非结合性 IF, IHC, ELISA, WB 0.05 mg Log in to see 2至3个工作日
$515.63
详细
Alexa Fluor 594 IF (p)   100 μL Log in to see 14至21个工作日
$405.90
详细
Alexa Fluor 350 IF (p)   100 μL Log in to see 14至21个工作日
$405.90
详细
Cy5.5 IF (p)   100 μL Log in to see 14至21个工作日
$405.90
详细

通过反应活性、应用领域、克隆类型和共轭标记 MAD2L2 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) 抗体

  1. Dog (Canine) Monoclonal MAD2L2 Primary Antibody for IF, WB - ABIN968795 : Chen, Fang: MAD2B is an inhibitor of the anaphase-promoting complex. in Genes & development 2001 (PubMed)
    Show all 2 Pubmed References

更多抗MAD2 Mitotic Arrest Deficient-Like 2 (Yeast)的相互作用对抗体

Mouse (Murine) MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) interaction partners

  1. This study demonstrates using super-resolution microscopy that numerous MAD2L2 microfoci are exclusively associated with euchromatin, similar to other factors of the DNA damage response. In the absence of MAD2L2 the amount of heterochromatin demarcated by H3K9me2 was significantly increased.

  2. Increased gonadotropins caused by the absence of functional oocytes and accumulation of DNA damage in cells caused by the lack of repair function could be responsible for the development and progression of ovarian tumors in the Rev7 mutant mouse.

  3. the Mad2l2 (MAD2B, Rev7) gene product is not only required by PGCs, but also by pluripotent embryonic stem cells (ESCs (显示 NR2E3 抗体)), depending on the growth conditions.

  4. results reveal an unexpected crucial function of REV7 downstream of 53BP1 in coordinating pathological DSB repair pathway choices in BRCA1-deficient cells

  5. that MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression

  6. These results demonstrated that Rev7 is essential in resolving the replication stalls caused by DNA damage during S phase.

  7. The function of Mad2l2 is essential in PGCs, and thus of high relevance for fertility

  8. Rev7 is essential for PGC (显示 PGC 抗体) maintenance by prevention of apoptotic cell death in the mouse.

  9. identification of the Rev7 binding surface of the Rev1 C-terminal domain

Xenopus laevis MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) interaction partners

  1. We have successfully isolated Xenopus laevis Mad2B and PRCC (显示 PRCC 抗体) cDNAs, so the well-established animal model Xenopus laevis can be used as a powerful system to study in detail the role of xPRCC (显示 PRCC 抗体) and xMad2B in the intricate processes of cell cycle control.

Human MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) interaction partners

  1. structure-based interaction analyses revealed an unprecedented mechanism involving CAMP's WK motif. Surprisingly, in one of the crystal forms, the MAD2L2-CAMP complex formed a dimeric structure in which the C-terminal region of MAD2L2 was swapped and adopted an immature structure

  2. REV7 is a previously undescribed FA gene, which we term FANCV

  3. Knockdown of REV7 inhibited the migration, invasion, and epithelial-mesenchymal transition (EMT (显示 ITK 抗体)) of breast cancer cells. Meanwhile, overexpression of REV7 promoted the migration, invasion, and EMT (显示 ITK 抗体) of breast cancer cells.

  4. hMAD2 also binds to the hREV7-binding sequence in hREV3 (显示 REV3L 抗体), whereas hMAD2 does not bind to a similar sequence in ADAM9 (显示 ADAM9 抗体) or ELK-1 (显示 ELK1 抗体) and hREV7 does not bind to the hMAD2-binding sequence in hMAD1 or hCDC20.

  5. data establish MAD2L2 as a crucial contributor to the control of DNA repair activity by 53BP1 (显示 TP53BP1 抗体) that promotes NHEJ by inhibiting 5' end resection downstream of RIF1 (显示 INSL6 抗体)

  6. results reveal an unexpected crucial function of REV7 downstream of 53BP1 in coordinating pathological DSB repair pathway choices in BRCA1-deficient cells

  7. that MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression

  8. Rev7 is essential for mutagenesis and S phase progression in UV-irradiated fibroblasts.

  9. These findings indicate that depletion of REV7 enhances sensitivity to cisplatin treatment in ovarian clear cell carcinoma (CCC), suggesting that REV7 is a candidate molecular target in CCC management.

  10. MAD2L2 helps to ensure a robustly bistable switch between APC (显示 APC 抗体)/C(CDC20 (显示 CDC20 抗体)) and APC (显示 APC 抗体)/C(CDH1 (显示 CDH1 抗体)) during the metaphase-to-anaphase transition, thereby contributing to mitotic fidelity.

MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) 抗原简介

蛋白简介

The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins.

Gene names and symbols associated with MAD2L2

  • mitotic arrest deficient 2 like 2 (mad2l2) 抗体
  • mitotic arrest deficient 2 like 2 (MAD2L2) 抗体
  • MAD2 mitotic arrest deficient-like 2 (Mad2l2) 抗体
  • mitotic arrest deficient 2 like 2 S homeolog (mad2l2.S) 抗体
  • mitotic arrest deficient 2 like 2 (Mad2l2) 抗体
  • MAD2 mitotic arrest deficient-like 2 (yeast) (MAD2L2) 抗体
  • si:dkey-23c22.2 (si:dkey-23c22.2) 抗体
  • 2310033C13Rik 抗体
  • mad2B 抗体
  • mad2l2 抗体
  • mad2l2-A 抗体
  • POLZ2 抗体
  • REV7 抗体
  • xMAD2L2 抗体
  • zgc:110299 抗体

Protein level used designations for MAD2L2

MAD2-like protein 2 , Mitotic arrest deficient 2-like protein 2 , mitotic spindle assembly checkpoint protein MAD2B , MAD2 homolog , mitotic arrest deficient 2-like protein 2 , Mitotic arrest defective protein 2B , MAD2 (mitotic arrest deficient, yeast, homolog)-like 2 , REV7 homolog , hREV7 , mitotic arrest deficient homolog-like 2 , polymerase (DNA-directed), zeta 2, accessory subunit

GENE ID SPECIES
448122 Xenopus (Silurana) tropicalis
457953 Pan troglodytes
714527 Macaca mulatta
71890 Mus musculus
394380 Xenopus laevis
10459 Homo sapiens
313702 Rattus norvegicus
506605 Bos taurus
419493 Gallus gallus
487443 Canis lupus familiaris
550258 Danio rerio
anti-MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) 抗体 精选生产商
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