MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) 蛋白 (MAD2L1)

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. 再加上,我们可以发MAD2L1 抗体 (122)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
MAD2L1 56150 Q9Z1B5
MAD2L1 4085 Q13257
大鼠 MAD2L1 MAD2L1 297176  

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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
大肠杆菌(E. Coli) His tag Human MAD2L1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 24至29个工作日
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大肠杆菌(E. Coli) His tag 100 μg Log in to see 14至15个工作日
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大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 48至57个工作日
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大肠杆菌(E. Coli) 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 48至57个工作日
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大肠杆菌(E. Coli) His tag 10 μg Log in to see 33至41个工作日
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大肠杆菌(E. Coli) 非结合性   10 μg Log in to see 24至29个工作日
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MAD2L1 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine)

Human , ,
, ,

引用最多的MAD2L1 蛋白

  1. Human MAD2L1 Protein expressed in Escherichia coli (E. coli) - ABIN2005328 : Mapelli, Massimiliano, Santaguida, Musacchio: The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint. in Cell 2007 (PubMed)
    Show all 5 references for 2005328

  2. Human MAD2L1 Protein expressed in Escherichia coli (E. coli) - ABIN667562 : Habu, Kim, Weinstein, Matsumoto: Identification of a MAD2-binding protein, CMT2, and its role in mitosis. in The EMBO journal 2002 (PubMed)
    Show all 2 references for 667562

  3. Human MAD2L1 Protein expressed in Escherichia coli (E. coli) - ABIN2181494 : Luo, Fang, Coldiron, Lin, Yu, Kirschner, Wagner: Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20. in Nature structural biology 2000 (PubMed)
    Show all 2 references for 2181494

更多MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1)互动伙伴

Mouse (Murine) MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) interaction partners

  1. reduced MAD2 (显示 MXI1 蛋白) levels attenuate the apoptotic response to mis (显示 AMH 蛋白)-segregating sex chromosomes and allow the formation of aneuploid sperm.

  2. p31comet-induced cell death is mediated by interactions with Mad2 (显示 MXI1 蛋白)

  3. study shows that Mad2 (显示 MXI1 蛋白) is a novel substrate for CCP6 (显示 AGBL4 蛋白) in megakaryocytes; Mad2 (显示 MXI1 蛋白) polyglutamylation plays a crucial role in the regulation of megakaryopoiesis

  4. Exacerbating chromosome missegregation in CENP-E (显示 CENPE 蛋白)+/- mice by reducing levels of another mitotic checkpoint component (显示 BUB3 蛋白), Mad2 (显示 MXI1 蛋白), results in elevated cell death and decreased tumor formation compared with reduction of either protein alone.

  5. Mad2 (显示 MXI1 蛋白) is also repressed by p53 (显示 TP53 蛋白) and its upregulation is required for chromosome instability in a p53 (显示 TP53 蛋白) mutant tumor model

  6. Data show that Mad2 (显示 MXI1 蛋白) haploinsufficiency is protective in the presence of a cycle-specific DNA synthesis agent in vivo, and Ape1/Ref-1 (显示 APEX1 蛋白) inhibitor in vitro.

  7. Pcid2 (显示 PCID2 蛋白) is essential for B cell survival through the regulation of MAD2 (显示 MXI1 蛋白) expression during B cell differentiation

  8. tumours that experience transient Mad2 (显示 MXI1 蛋白) overexpression and consequent chromosome instability recur at markedly elevated rates

  9. a functional Mad2 (显示 MXI1 蛋白)-dependent spindle checkpoint exists during the first meiotic division in mammalian oocytes

  10. Data show that the loss of Trrap leads to chromosome missegregation, mitotic exit failure and compromised mitotic checkpoints, which are caused by defective Trrap-mediated transcription of the mitotic checkpoint (显示 BUB3 蛋白) proteins Mad1 (显示 MXD1 蛋白) and Mad2 (显示 MXI1 蛋白).

Human MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) interaction partners

  1. Thes authors show that p31 (显示 ATP6V1E1 蛋白)(comet) binding to the TRIP13 (显示 TRIP13 蛋白) N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 (显示 TRIP13 蛋白) "pore loops", which then unfold MAD2 in the presence of ATP.

  2. catalytic activation of the spindle assembly checkpoint depends on regulated protein-protein interactions that accelerate the spontaneous but rate-limiting conversion of MAD2 required for mitotic checkpoint (显示 BUB3 蛋白) complex assembly

  3. in addition to its role in checkpoint signaling, MAD2 ensures chromosome stability through the regulation of AURORA B (显示 AURKB 蛋白).

  4. Aberrant Mad2 expression was associated with cell proliferation and genetic instability, which may contribute to the carcinogenesis of PGI (显示 BGN 蛋白)-DLBCL. Mad2 overexpression indicated a poor DFS (显示 FST 蛋白).

  5. interactions between Mad2 and H3K4 regulate resolution of the spindle assembly checkpoint by limiting closed Mad2 availability for Cdc20 (显示 CDC20 蛋白) inhibition.

  6. we showed that BubR1 (显示 BUB1B 蛋白) and Mad2 are overexpressed in oral squamous cell carcinoma cell lines and linked such overexpression to attenuated spindle assembly checkpoint activity.

  7. Studied the folding/unfolding process of the open and closed conformers of human Mad2.

  8. MAD1L1 (显示 MAD1L1 蛋白) Arg558His and MAD2L1 Leu84Met interaction with smoking increase the risk of colorectal cancer

  9. p31comet-induced cell death is mediated by interactions with Mad2

  10. MAD2L1 and BUB1 (显示 BUB1 蛋白) may play important roles in breast cancer progression, and measuring the expression of these genes may assist the prediction of breast cancer prognosis.

蛋白简介MAD2L1

蛋白简介

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.

Gene names and symbols associated with MAD2L1

  • MAD2 mitotic arrest deficient-like 1 (yeast) (MAD2L1)
  • MAD2 mitotic arrest deficient-like 1 (yeast) (mad2l1)
  • MAD2 mitotic arrest deficient-like 1 (mad2l1)
  • MAD2 mitotic arrest deficient-like 1 (MAD2L1)
  • MAD2 mitotic arrest deficient-like 1 (yeast) (LOC100218172)
  • MAD2 mitotic arrest deficient-like 1 (Mad2l1)
  • MAD2 mitotic arrest deficient-like 1 (yeast) (Mad2l1)
  • AA673185 蛋白
  • cb408 蛋白
  • HSMAD2 蛋白
  • MAD2 蛋白
  • MAD2L1 蛋白
  • XMad2 蛋白
  • zgc:112133 蛋白

Protein level used designations for MAD2L1

MAD2-like 1 , mitotic spindle assembly checkpoint protein MAD2A , spindle assembly checkpoint protein Mad2 , MAD2 mitotic arrest deficient-like 1 (yeast) , MAD2 mitotic arrest deficient-like 1 , MAD2 (mitotic arrest deficient, homolog)-like 1 , MAD2-like protein 1 , mitotic arrest deficient 2-like protein 1 , MAD2 (mitotic arrest deficient, yeast, homolog)-like 1 , mitotic arrest deficient, yeast, homolog-like 1

GENE ID SPECIES
461661 Pan troglodytes
550434 Danio rerio
708574 Macaca mulatta
787996 Bos taurus
100125170 Xenopus (Silurana) tropicalis
100137358 Papio anubis
100218172 Taeniopygia guttata
56150 Mus musculus
380433 Xenopus laevis
4085 Homo sapiens
422675 Gallus gallus
476070 Canis lupus familiaris
337870 Bos taurus
297176 Rattus norvegicus
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