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LOXL1 encodes a member of the lysyl oxidase gene family. 再加上，我们可以发LOXL1 试剂盒 (17) 和 LOXL1 蛋白 (15)和数多这个蛋白质的别的产品。
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Human Polyclonal LOXL1 Primary Antibody for IF, WB - ABIN517560
Sethi, Mao, Wordinger, Clark: Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells. in Investigative ophthalmology & visual science 2011
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Human Polyclonal LOXL1 Primary Antibody for WB - ABIN517559
Schlötzer-Schrehardt, Hammer, Krysta, Hofmann-Rummelt, Pasutto, Sasaki, Kruse, Zenkel: LOXL1 deficiency in the lamina cribrosa as candidate susceptibility factor for a pseudoexfoliation-specific risk of glaucoma. in Ophthalmology 2012
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Cow (Bovine) Polyclonal LOXL1 Primary Antibody for WB - ABIN2785878
Ohmura, Yasukawa, Minami, Sugi, Oba, Nagata, Kyogoku, Ohshima, Aoki, Imaizumi: Cardiomyocyte-specific transgenic expression of lysyl oxidase-like protein-1 induces cardiac hypertrophy in mice. in Hypertension research : official journal of the Japanese Society of Hypertension 2012
high lysyl oxidase (显示 LOX 抗体) activity is associated with ischemic hearts.
These findings provide evidence for a functional role of alternative splicing coupled to NMD in the posttranscriptional regulation of LOXL1 gene expression and suggest this mechanism to represent a dynamic mode of adapting LOXL1 expression to PEX (显示 PHEX 抗体)-associated environmental and nutritional cues.
remenopausal and postmenopausal women with Pelvic Organ Prolapse (POP (显示 PREP 抗体)) exhibit differential expression of LOXL1 suggesting different pathways in the pathogenesis of POP (显示 PREP 抗体). The role of biopsy location on LOXL1 expression requires further investigation.
In this study, we found no significant association between allele and genotype frequencies of APOE (显示 APOE 抗体); the intronic SNP rs2165241 and the non-synonymous SNP rs3825942 in exon 1 of LOXL1 are significantly associated with pseudoexfoliation syndrome and exfoliation glaucoma in the Turkish population.
The LOXL1 SNPs, rs1048661 and rs3825942, are associated with PXF (显示 PEX19 抗体) in the South Indian population correlating with lowered LOX (显示 LOX 抗体) activity in the aqueous humor. The increased level of total TGF-beta (显示 TGFB1 抗体) in the aqueous humor of PXF (显示 PEX19 抗体) cases is possibly associated with LOX (显示 LOX 抗体) regulation which needs further investigation.
A rare protective allele at LOXL1,Tyr407Phe, was identified. It is found exclusively in the Japanese population. It confers 25-fold resistance to XFS (显示 FST 抗体). It segregated with the common rs3825942[A] (p.Asp153) in all but 2 patients examined. In spheroids, this haplotype conferred a significant increase in the strength of cellular adhesion in comparison to 3 haplotypes with the wild-type allele.
Findings of this current study indicate a different LOXL1 gene expression pattern compared with a recent study that was also performed in the Turkish population.
LOXL1 transcriptional activity was dramatically reduced when a recombinant DNMT3A (显示 DNMT3A 抗体) was concomitantly overexpressed.
The present study, for the first time, shows that the pseudoexfoliation syndrome-associated variant residues in LOXL1 influence processing of the protein, most likely by BMP-1 (显示 BMP1 抗体).
In this study group of Turkish population, no LOXL1 mutations were found. No associations between the defined SNPs (A320A, R141L and F184F) and the severity of the disease were detected.
Here we show that orthotopic implantation of rat prostate AT-1 tumour cells increased LOX (显示 LOX 抗体) and LOXLs mRNA expressions in the tumour and in the surrounding non-malignant prostate tissue
LOXL1-/- mutant mice develop appendicular and axial skeletal phenotypes characterized by decreased bone volume fraction and compromised trabecular microstructure, predominantly in females
Elimination of LOXL1 in mice impairs the blood-aqueous humor barrier in the ocular anterior segment and causes lens abnormalities consistent with cataract formation, but does not result in deposition of macromolecular material or glaucoma.
There is a possible fundamental role of LOXL-1 in cardiac hypertrophy.
loxl appears non-allelic to rough coat in mice; heart- and skin-specific downregulation of LOXL in rough coat mice, however, may contribute to the extracellular matrix alterations and the rough coat phenotype
Data report that cells in the hippocampal granule cell layer of LOXL -/- mice have significantly smaller somas and muted (显示 MUTED 抗体) long-term potentiation compared to LOXL +/+ mice.
pro-regions of lysyl oxidase (显示 LOX 抗体) and lysyl oxidase-like 1 are required for deposition onto elastic fibers
LOXL1 deficiency caused failure of elastic fiber homeostasis leading to pelvic floor disorders
LOXL1 (lysyl oxidase-like 1) mutation results in a global defect in connective tissues and correlates with altered biomechanical behavior of the vagina and supportive tissues
LOXL1-KO lower urogenital tract anatomical and functional phenotype resembles female pelvic floor dysfunction in humans. Elastin (显示 ELN 抗体) disorganization may lead to such functional abnormalities.
Loxl1(-/-) males bred with control females demonstrated relative fecundity values intermediate between Loxl1(-/-) pairs (lowest fecundity) and control pairs (highest fecundity), suggesting a component of male-factor infertility.
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
lysyl oxidase-like 1
, lysyl oxidase homolog 1-like
, lysyl oxidase homolog 1
, lysyl oxidase-like protein 1
, lysyl oxidase 2