Like-Glycosyltransferase (LARGE) ELISA试剂盒

LARGE, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. 再加上,我们可以发Like-Glycosyltransferase 抗体 (40)Like-Glycosyltransferase 蛋白 (6)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
LARGE 9215 O95461
LARGE 16795 Q9Z1M7
大鼠 LARGE LARGE 361368  

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Human Like-Glycosyltransferase (LARGE) interaction partners

  1. This study suggests LARGE as the first known modifier of plasma antithrombin (显示 SERPINC1 ELISA试剂盒).

  2. results reveal that the LARGE-glycan of dystroglycan serves as a tunable extra (显示 DAG1 PLURAL_@3194@)cellular matrix protein scaffold, the extension of which is required for normal skeletal muscle function

  3. LARGE could act as a bifunctional glycosyltransferase, with xylosyltransferase and glucuronyltransferase activities, which produced repeating units of [-3-xylose-alpha1,3-glucuronic acid-beta1-]; allowed alpha-DG to bind laminin-G domain-containing ECM (显示 MMRN1 ELISA试剂盒) ligands

  4. the ligand-binding activity of alpha-dystroglycan is conferred primarily by LARGE modification at Thr (显示 TRH ELISA试剂盒)-317 and -319, within the highly conserved first 18 amino acids of the mucin (显示 SLC13A2 ELISA试剂盒)-like domain

  5. LARGE2 (显示 GYLTL1B ELISA试剂盒) was found to support the maturation of alpha-dystroglycan more effectively than LARGE.

  6. LARGE repression is responsible for the defects in dystroglycan (显示 DAG1 PLURAL_@3194@)-mediated cell adhesion that are observed in epithelium-derived cancer cells and point to a defect of dystroglycan (显示 DAG1 PLURAL_@3194@) glycosylation as a factor in cancer progression

Mouse (Murine) Like-Glycosyltransferase (LARGE) interaction partners

  1. data suggest LARGE overexpression may only be deleterious under a forced regenerative context, such as that resulting from a reduction in FKRP (显示 FKRP ELISA试剂盒): in the absence of such a defect we show that systemic expression of LARGE can indeed act therapeutically, and that even dramatic LARGE overexpression is well-tolerated in heart and skeletal muscle

  2. MBP1 (显示 ENO1 ELISA试剂盒) inhibits Ab fibril formation in vitro and demonstrate the ability of MBP1 (显示 ENO1 ELISA试剂盒) to reduce Ab pathology and improve behavioral performance.

  3. The overexpression of LARGE aggravates muscular dystrophy by suppressing the muscle regeneration and this adverse effect is mediated via reduced expression of IGF-1 (显示 IGF1 ELISA试剂盒).

  4. Endogenous glucuronyltransferase activity of LARGE or LARGE2 (显示 GYLTL1B ELISA试剂盒) required for functional modification of alpha-dystroglycan in cells and tissues.

  5. The overexpression of LARGE leads to a shortened lifespan and worsening of the FKRP (显示 FKRP ELISA试剂盒)-MD phenotype

  6. blocking Large during muscle regeneration results in synthesis of dystroglycan (显示 DAG1 PLURAL_@3194@) with minimal LARGE-glycan repeats in association with less compact basement membrane, immature neuromuscular junctions, and dysfunctional muscle predisposed to dystrophy

  7. Muscular dystrophy defects are primarily due to the effects of LARGE and glycosylated dystroglycan (显示 DAG1 PLURAL_@3194@) in stabilizing the endplate of the neuromuscular junction.

  8. LARGE could act as a bifunctional glycosyltransferase, with xylosyltransferase and glucuronyltransferase activities, which produced repeating units of [-3-xylose-alpha1,3-glucuronic acid-beta1-]; allowed alpha-DG to bind laminin-G domain-containing ECM (显示 MMRN1 ELISA试剂盒) ligands

  9. Differential glycosylation of alpha-dystroglycan and proteins other than alpha-dystroglycan by like-glycosyltransferase.

  10. a mechanism by which Large competes with galactosyltransferase (显示 a3GALT2 ELISA试剂盒) to target GlcNAc terminals to induce the functional glycans on alpha-DG

Like-Glycosyltransferase (LARGE) 抗原简介

Antigen Summary

This gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Gene names and symbols associated with LARGE

  • like-glycosyltransferase (LARGE) 抗体
  • like-glycosyltransferase (large) 抗体
  • glycosyltransferase-like 1B (GYLTL1B) 抗体
  • like-glycosyltransferase (Large) 抗体
  • BPFD36 抗体
  • DKFZp459G0120 抗体
  • enr 抗体
  • fg 抗体
  • froggy 抗体
  • Gyltl1a 抗体
  • gyltl1b 抗体
  • gyltl1b-b 抗体
  • LARGE 抗体
  • Mbp-1 抗体
  • Mbp1 抗体
  • mdc1d 抗体
  • MDDGA6 抗体
  • MDDGB6 抗体
  • mKIAA0609 抗体
  • myd 抗体
  • NV15834 抗体

Protein level used designations for LARGE

glycosyltransferase-like protein LARGE1 , glycosyltransferase-like 1A , acetylglucosaminyltransferase-like 1A , acetylglucosaminyltransferase-like protein , like-glycosyltransferase , glycosyltransferase-like protein LARGE1-like , glycosyltransferase-like protein LARGE2 , like-acetylglucosaminyltransferase , myodystrophy , glycosyltransferase-like 1B , glycosyltransferase-like 1B-B , glycosyltransferase-like protein LARGE2-B

GENE ID SPECIES
418062 Gallus gallus
446213 Danio rerio
470192 Pan troglodytes
717403 Macaca mulatta
100068935 Equus caballus
100118066 Nasonia vitripennis
100174135 Pongo abelii
100346008 Oryctolagus cuniculus
100366528 Saccoglossus kowalevskii
100410756 Callithrix jacchus
100466251 Ailuropoda melanoleuca
423200 Gallus gallus
9215 Homo sapiens
16795 Mus musculus
361368 Rattus norvegicus
474521 Canis lupus familiaris
506466 Bos taurus
734944 Xenopus laevis
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