anti-Like-Glycosyltransferase (LARGE) 抗体

LARGE, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. 再加上,我们可以发Like-Glycosyltransferase 蛋白 (6)Like-Glycosyltransferase 试剂盒 (3)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
LARGE 9215 O95461
LARGE 16795 Q9Z1M7
LARGE 361368  

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Showing 10 out of 40 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-LARGE Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 24至29个工作日
¥3,074.65
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Cow 山羊 非结合性 EIA, WB   0.1 mg Log in to see 30至37个工作日
¥3,065.96
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山羊 非结合性 ELISA, WB Western Blot: LARGE Antibody [NBP1-49865] - Analysis of LARGE (aa421-433) in Human Kidney lysate (35ug protein in RIPA buffer) using NBP1-49865 at 1 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 25至31个工作日
¥3,333.96
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山羊 非结合性 ELISA, WB 0.1 mg Log in to see 24至29个工作日
¥4,732.45
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Bat 山羊 非结合性 ELISA, WB 100 μg Log in to see 29至35个工作日
¥6,088.05
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Bat 非结合性 WB 50 μg Log in to see 29至35个工作日
¥5,538.93
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Cow 山羊 非结合性 ELISA   0.1 mg Log in to see 25至31个工作日
¥2,594.28
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山羊 非结合性 ELISA, WB   0.1 mg Log in to see 24至29个工作日
¥4,432.21
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山羊 非结合性 ELISA   100 μg Log in to see 29至35个工作日
¥5,127.12
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山羊 非结合性 ELISA, WB   100 μg Log in to see 24至29个工作日
¥9,230.97
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通过反应活性、应用领域、克隆类型和共轭标记 LARGE 抗体

特性 应用范围 宿主 克隆类型 标记
Human , ,
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Mouse (Murine) ,
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Rat (Rattus) ,
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引用最多的anti-Like-Glycosyltransferase 抗体

  1. Cow (Bovine) Polyclonal LARGE Primary Antibody for ELISA - ABIN4229228 : de Bernabé, Inamori, Yoshida-Moriguchi, Weydert, Harper, Willer, Henry, Campbell: Loss of alpha-dystroglycan laminin binding in epithelium-derived cancers is caused by silencing of LARGE. in The Journal of biological chemistry 2009 (PubMed)

更多抗Like-Glycosyltransferase的相互作用对抗体

Human Like-Glycosyltransferase (LARGE) interaction partners

  1. This study suggests LARGE as the first known modifier of plasma antithrombin (显示 SERPINC1 抗体).

  2. results reveal that the LARGE-glycan of dystroglycan serves as a tunable extracellular matrix protein scaffold, the extension of which is required for normal skeletal muscle function

  3. LARGE could act as a bifunctional glycosyltransferase (显示 GTDC2 抗体), with xylosyltransferase and glucuronyltransferase activities, which produced repeating units of [-3-xylose-alpha1,3-glucuronic acid-beta1-]; allowed alpha-DG to bind laminin-G domain-containing ECM (显示 MMRN1 抗体) ligands

  4. the ligand-binding activity of alpha-dystroglycan is conferred primarily by LARGE modification at Thr (显示 TRH 抗体)-317 and -319, within the highly conserved first 18 amino acids of the mucin (显示 SLC13A2 抗体)-like domain

  5. LARGE2 (显示 GYLTL1B 抗体) was found to support the maturation of alpha-dystroglycan more effectively than LARGE.

  6. LARGE repression is responsible for the defects in dystroglycan-mediated cell adhesion that are observed in epithelium-derived cancer cells and point to a defect of dystroglycan glycosylation as a factor in cancer progression

Mouse (Murine) Like-Glycosyltransferase (LARGE) interaction partners

  1. data suggest LARGE overexpression may only be deleterious under a forced regenerative context, such as that resulting from a reduction in FKRP (显示 FKRP 抗体): in the absence of such a defect we show that systemic expression of LARGE can indeed act therapeutically, and that even dramatic LARGE overexpression is well-tolerated in heart and skeletal muscle

  2. MBP1 (显示 ENO1 抗体) inhibits Ab fibril formation in vitro and demonstrate the ability of MBP1 (显示 ENO1 抗体) to reduce Ab pathology and improve behavioral performance.

  3. The overexpression of LARGE aggravates muscular dystrophy by suppressing the muscle regeneration and this adverse effect is mediated via reduced expression of IGF-1 (显示 IGF1 抗体).

  4. Endogenous glucuronyltransferase activity of LARGE or LARGE2 (显示 GYLTL1B 抗体) required for functional modification of alpha-dystroglycan in cells and tissues.

  5. The overexpression of LARGE leads to a shortened lifespan and worsening of the FKRP (显示 FKRP 抗体)-MD phenotype

  6. blocking Large during muscle regeneration results in synthesis of dystroglycan with minimal LARGE-glycan repeats in association with less compact basement membrane, immature neuromuscular junctions, and dysfunctional muscle predisposed to dystrophy

  7. Muscular dystrophy defects are primarily due to the effects of LARGE and glycosylated dystroglycan in stabilizing the endplate of the neuromuscular junction.

  8. LARGE could act as a bifunctional glycosyltransferase (显示 GTDC2 抗体), with xylosyltransferase and glucuronyltransferase activities, which produced repeating units of [-3-xylose-alpha1,3-glucuronic acid-beta1-]; allowed alpha-DG to bind laminin-G domain-containing ECM (显示 MMRN1 抗体) ligands

  9. Differential glycosylation of alpha-dystroglycan and proteins other than alpha-dystroglycan by like-glycosyltransferase.

  10. a mechanism by which Large competes with galactosyltransferase to target GlcNAc terminals to induce the functional glycans on alpha-DG

Like-Glycosyltransferase (LARGE) 抗原简介

蛋白简介

This gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Gene names and symbols associated with LARGE

  • like-glycosyltransferase (LARGE) 抗体
  • like-glycosyltransferase (large) 抗体
  • glycosyltransferase-like 1B (GYLTL1B) 抗体
  • like-glycosyltransferase (Large) 抗体
  • BPFD36 抗体
  • DKFZp459G0120 抗体
  • enr 抗体
  • fg 抗体
  • froggy 抗体
  • Gyltl1a 抗体
  • gyltl1b 抗体
  • gyltl1b-b 抗体
  • LARGE 抗体
  • Mbp-1 抗体
  • Mbp1 抗体
  • mdc1d 抗体
  • MDDGA6 抗体
  • MDDGB6 抗体
  • mKIAA0609 抗体
  • myd 抗体
  • NV15834 抗体

Protein level used designations for LARGE

glycosyltransferase-like protein LARGE1 , glycosyltransferase-like 1A , acetylglucosaminyltransferase-like 1A , acetylglucosaminyltransferase-like protein , like-glycosyltransferase , glycosyltransferase-like protein LARGE1-like , glycosyltransferase-like protein LARGE2 , like-acetylglucosaminyltransferase , myodystrophy , glycosyltransferase-like 1B , glycosyltransferase-like 1B-B , glycosyltransferase-like protein LARGE2-B

GENE ID SPECIES
418062 Gallus gallus
446213 Danio rerio
470192 Pan troglodytes
717403 Macaca mulatta
100068935 Equus caballus
100118066 Nasonia vitripennis
100174135 Pongo abelii
100346008 Oryctolagus cuniculus
100366528 Saccoglossus kowalevskii
100410756 Callithrix jacchus
100466251 Ailuropoda melanoleuca
423200 Gallus gallus
9215 Homo sapiens
16795 Mus musculus
361368 Rattus norvegicus
474521 Canis lupus familiaris
506466 Bos taurus
734944 Xenopus laevis
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