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The product encoded by LPXN is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. 再加上，我们可以发Leupaxin 蛋白 (5) 和 Leupaxin 试剂盒 (2)和数多这个蛋白质的别的产品。
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this is the first demonstration of a role for the leupaxin in the regulation of hepatocellular carcinoma progression, at least in part, by enhancing beta-catenin (显示 CTNNB1 抗体) transcription activity.
The full-length leupaxin binds to the Pyk2 (显示 PTK2B 抗体)-focal adhesion targeting domain.
Authors demonstrate that LPXN directly influences cytoskeletal dynamics via interaction with the actin-binding protein (显示 KPTN 抗体) CaD (显示 CAD 抗体) and regulates CaD (显示 CAD 抗体) phosphorylation by recruiting ERK (显示 EPHB2 抗体) to highly dynamic structures within PCa (显示 FLVCR1 抗体) cells.
Results show that leupaxin has particular influence on the progression and invasion of breast cancer cells and may therefore represent an interesting candidate protein for diagnosis and therapeutic interventions.
first evidence of dynamic regulation of leupaxin localization and tyrosine phosphorylation by G-Protein Coupled Receptors
leupaxin functions as a paxillin (显示 PXN 抗体) counterpart that potently suppresses the tyrosine phosphorylation of paxillin (显示 PXN 抗体) during integrin signaling.
leupaxin may be a critical nucleating component of the osteoclast podosomal signaling complex
Leupaxin binding to tyrosine phosphatase PEP suggests that leupaxin may function as a signal-transducing complex with PEP.
These data demonstrate that LPXN forms a signaling complex with Pyk2 (显示 PTK2B 抗体), c-Src (显示 SRC 抗体), and PTP-PEST (显示 PTPN12 抗体) to regulate migration of prostate cancer cells.
Leupaxin plays an inhibitory role in BCR (显示 BCR 抗体) signaling and B cell function.
Association of the scaffold protein (显示 HOMER1 抗体) LPXN with Src (显示 SRC 抗体) adds further complexity to the organization of the podosomal signaling complex in osteoclasts.
Leupaxin is enriched in mouse vascular smooth muscle and its expression is dynamically regulated during development.
The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.