Leucine Rich Repeat and Ig Domain Containing 1 蛋白 (LINGO1)

May play a role in regulating axonal regeneration and plasticity in the adult central nervous system (By similarity). 再加上,我们可以发LINGO1 抗体 (131)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
LINGO1 84894 Q96FE5
LINGO1 235402 Q9D1T0
大鼠 LINGO1 LINGO1 315691  

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Insect Cells 小鼠 rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 68至77个工作日
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Insect Cells rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 68至77个工作日
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小麦胚 GST tag 2 μg Log in to see 29至34个工作日
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HOST_HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 28至34个工作日
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LINGO1 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, , ,
Mouse (Murine)
,

更多Leucine Rich Repeat and Ig Domain Containing 1 (LINGO1)互动伙伴

Human Leucine Rich Repeat and Ig Domain Containing 1 (LINGO1) interaction partners

  1. LINGO1 rs11856808 plays a protective role by decreasing the risk for PD, but not for MSA (显示 TPO 蛋白), in Chinese population.

  2. LINGO1 protein acts as a gateway protein internalizing into the tumor cells when engaged by antibody and can carry antibody conjugated with drugs to kill Ewing sarcoma cells.

  3. Data indicate that leucine-rich repeat neuronal protein 1 (LINGO-1) is intracellular and competes with Nogo-66 receptor (NgR (显示 RTN4R 蛋白)) for binding to p75 neurotrophin receptor (p75NTR (显示 NGFR 蛋白)).

  4. The results of this study show Increased LINGO1 in the cerebellum of essential tremor patients.

  5. Lingo-1 signaling is altered in the schizophrenia brain.

  6. LINGO-1 can directly bind to ErbB2 (显示 ERBB2 蛋白), block ErbB2 (显示 ERBB2 蛋白) translocation into lipid rafts, and inhibit its phosphorylation.

  7. This review found that several gene variants in the LINGO1 gene may increase the risk of essential tremor.

  8. LINGO1 variants are associated with essential tremor in Chinese Han female patients.

  9. LINGO-1 potentiates neuronal apoptosis, likely by inhibiting WNK3 kinase activity.

  10. Results of a meta-analysis suggest a relationship between LINGO1 rs11856808 polymorphism and risk of essential tremor (ET) and familial ET, while rs9652490 polymorphism is only associated with the risk for familial ET.

Mouse (Murine) Leucine Rich Repeat and Ig Domain Containing 1 (LINGO1) interaction partners

  1. These data provide morphometric and functional evidence of enhancement of remyelination associated with antagonism of LINGO-1

  2. LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions

  3. a novel role for LINGO-1 in neural stem cell differentiation to neurons

  4. inhibitory agents of LINGO-1 activity can protect dopaminergic neurons against degeneration

  5. Lingo1 antagonist promotes spinal cord remyelination and axonal integrity in MOG (显示 MOG PLURAL_@33193@)-induced experimental autoimmune encephalomyelitis.

蛋白简介LINGO1

蛋白简介

May play a role in regulating axonal regeneration and plasticity in the adult central nervous system (By similarity).

Gene names and symbols associated with LINGO1

  • leucine rich repeat and Ig domain containing 1 (LINGO1)
  • leucine rich repeat and Ig domain containing 1 (lingo1)
  • leucine rich repeat and Ig domain containing 1 (LOC100228050)
  • leucine rich repeat and Ig domain containing 1 (Lingo1)
  • 4930471K13Rik 蛋白
  • AV148400 蛋白
  • DKFZp459P0736 蛋白
  • LERN1 蛋白
  • LINGO-1 蛋白
  • Lrrn6a 蛋白
  • UNQ201 蛋白

Protein level used designations for LINGO1

leucine rich repeat and Ig domain containing 1 , leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 , Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 , leucine rich repeat neuronal 6A , leucine-rich repeat and immunoglobilin domain-containing protein 1 , leucine-rich repeat and immunoglobulin domain-containing protein 1 , leucine-rich repeat neuronal protein 1 , leucine-rich repeat neuronal protein 6A , leucine-rich repeat neuronal 6A , cLINGO-1

GENE ID SPECIES
453764 Pan troglodytes
100061441 Equus caballus
100101739 Xenopus (Silurana) tropicalis
100171931 Pongo abelii
100228050 Taeniopygia guttata
84894 Homo sapiens
235402 Mus musculus
415344 Gallus gallus
487660 Canis lupus familiaris
100155465 Sus scrofa
520694 Bos taurus
315691 Rattus norvegicus
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