Use your antibodies-online credentials, if available.
LEFTY2 encodes a member of the TGF-beta family of proteins. 再加上，我们可以发LEFTY2 蛋白 (11) 和 LEFTY2 试剂盒 (7)和数多这个蛋白质的别的产品。
Showing 10 out of 60 products:
results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning
we find that Cyclops is specifically required for the maintenance of lefty1 (显示 LEFTY1 抗体) and lefty2 transcription
study reports that microRNA-430 (miR (显示 MYLIP 抗体)-430) dampens and balances the expression of the transforming growth factor-beta (TGF-beta) Nodal agonist squint and the TGF-beta (显示 TGFB1 抗体) Nodal antagonist lefty
results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A (显示 DNMT3A 抗体) and DNMT3B (显示 DNMT3B 抗体); findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation (显示 HELLS 抗体) and demethylation crucial to regulation of key signalling pathways in early body plan formation
LEFTY2 regulates the expression and activity of ENaC (显示 SCNN1A 抗体) in endometrial epithelial cells via SGK1 (显示 SGK1 抗体).
Results indicate that microRNA miR (显示 MLXIP 抗体)-127 accelerates mesendoderm differentiation of embryonic stem cells through nodal signaling by targeting left-right determination factor 2 (Lefty2).
exogenous lefty1 (显示 LEFTY1 抗体) administered to mice restored the endogenous expression levels of lefty1 (显示 LEFTY1 抗体). The present study demonstrated that lefty1 (显示 LEFTY1 抗体) attenuated renal interstitial injury by inhibiting the Smaddependent TGFb1 (显示 TGFB1 抗体) signaling pathway
Lefty-1 (显示 LEFTY1 抗体) may prevent TGFB1 (显示 TGFB1 抗体)-induced fibroblast-myofibroblast transdifferentiation in part via modulation of Smad3 (显示 SMAD3 抗体), JNK-3 (显示 MAPK10 抗体), and BMP-5 (显示 BMP5 抗体) signaling.
The expression of lefty in RCC (显示 XRCC1 抗体) cells was lower than that in adjacent non-tumor cells, which may result in the overexpression of nodal, thereby promoting the growth of RCC (显示 XRCC1 抗体).
Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2) has a conserved role in left-right asymmetry.
Taken together, these results suggest that optimal expression of Lefty1 (显示 LEFTY1 抗体) and Lefty2 is critical for the balanced differentiation of mESCs into three germ layers.
Beta-catenin (显示 CTNNB1 抗体) can recruit the H3K4me2/1 demethylase (显示 MBD2 抗体) LSD1 (显示 KDM1A 抗体) to regulate the expression of the tumor suppressor Lefty1 (显示 LEFTY1 抗体) in mouse embryonic stem cells.
Lefty can antagonise TGF-beta1 (显示 TGFB1 抗体) mediated epithelial-mesenchymal transition in renal tubular epithelial cells.
LEFTY2 down-regulates MKi67 (显示 MKI67 抗体) expression and FAK (显示 PTK2 抗体) activity, up-regulates miR (显示 MLXIP 抗体)-200a and E-cadherin (显示 CDH1 抗体), and is thus a powerful negative regulator of endometrial cell proliferation and migration.
Lefty A may account for the tumor suppressive activity of human adult stem cells.
Findings suggest that Lefty2 is negatively modulated by miR (显示 MLXIP 抗体)-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification.
findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression
nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells
Addition of recombinant LEFTY-A to explants induced MMP-9 (显示 MMP9 抗体) in most samples, a response prevented by ovarian steroids.
LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation.
This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants.
, endometrial bleeding associated factor
, left-right determination factor 1
, left-right determination factor 2
, left-right determination factor 2-like
, left-right determination, factor B
, protein lefty-1
, stimulated by retinoic acid gene 3 protein
, transforming growth factor beta-4
, endometrial bleeding-associated factor
, left-right determination factor A
, protein lefty-2
, protein lefty-A
, left-right determination factor B
, left-right determination, factor A
, protein lefty-B