LIM and Senescent Cell Antigen-Like Domains 1 蛋白 (LIMS1)

The protein encoded by LIMS1 is an adaptor protein which contains five LIM domains, or double zinc fingers. 再加上,我们可以发LIM and Senescent Cell Antigen-Like Domains 1 抗体 (55)LIM and Senescent Cell Antigen-Like Domains 1 试剂盒 (1)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
LIMS1 3987 P48059
大鼠 LIMS1 LIMS1 499443  
LIMS1 110829 Q99JW4
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LIMS1 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,
Mouse (Murine)

更多LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1)互动伙伴

Human LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) interaction partners

  1. Mammalian cells have two functional PINCH proteins, PINCH1 and PINCH2 (显示 LIMS2 蛋白). PINCH not only binds to Nck2 (显示 NCK2 蛋白) and engages in the signaling of growth factor receptors, but also forms a ternary complex with ILK (显示 ILK 蛋白) and parvin (显示 PARVA 蛋白) (IPP (显示 IPP 蛋白) complex).

  2. our data suggest an essential role of PINCH1, ILK (显示 ILK 蛋白) and ILKAP (显示 ILKAP 蛋白) for the radioresistance of p53 (显示 TP53 蛋白)-wildtype glioblastoma multiforme cells

  3. Data suggest that PINCH1 and Nck2 (显示 NCK2 蛋白) critically participate in the regulation of cellular radiosensitivity and EGFR (显示 EGFR 蛋白) function and downstream signaling in a cellular model of human squamous cell carcinoma.

  4. Downregulation of PINCH1 is associated with metastatic breast cancer.

  5. changes in CSF (显示 CSF2 蛋白) levels of PINCH appear to correlate with changes in blood CD4 (显示 CD4 蛋白) count and with changes in CSF (显示 CSF2 蛋白) hyperphosphorylated Tau levels

  6. two novel genes, galectin 9 (显示 LGALS9 蛋白) and PINCH, were expressed at much higher levels in cancerous lesions than in normal tissues in all the patients with clear-cell carcinoma who were examined

  7. PINCH predicts survival in rectal cancer patients with RT, but not in patients without RT. The expression of PINCH may be regulated by radiation and by environmental factors surrounding the cells.

  8. PINCH is increased and binds to hp-Tau. These studies address a new mechanism by which AD and HIV may intersect and identify PINCH as a contributing factor to the accumulation of hyperphosphorylated Tau.

  9. Pinch-1 mRNA and protein were significantly up-regulated in acute lymphoblastic leukemia and acute myeloid leukemia (显示 BCL11A 蛋白) bone marrow stromal cells compared to normal bone marrow stromal cells (p<0.01).

  10. PINCH protein might play an important role in the tumourigenesis and metastasis of gastric adenocarcinoma.

Mouse (Murine) LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) interaction partners

  1. findings suggest that PINCH-1 regulates integrin-mediated adhesion of keratinocytes through the interactions with ILK (显示 ILK 蛋白) as well as EPLIN (显示 LIMA1 蛋白).

  2. Rsu-1 (显示 RSU1 蛋白) expression is dramatically decreased in PINCH double knockout mouse livers.

  3. PINCH is increased and binds to hp-Tau. These studies address a new mechanism by which AD and HIV may intersect and identify PINCH as a contributing factor to the accumulation of hyperphosphorylated Tau.

  4. PINCH-1 inhibits JNK (显示 MAPK8 蛋白)-mediated apoptosis by stabilising the PINCH-1 binding protein RSU-1 (显示 RSU1 蛋白) and promotes Bcl-2 (显示 BCL2 蛋白)-dependent pro-survival signalling downstream of integrins.

  5. Data suggest that the adapter protein (显示 GRB10 蛋白) PINCH1 critically participates in the regulation of the cellular radiosensitivity of normal and malignant cells similarly under adhesion and suspension conditions.

  6. PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes.

  7. These results provide important evidence for a crucial role of the PINCH-1-ILK (显示 ILK 蛋白)-alpha-parvin (显示 PARVA 蛋白) complex in the control of podocyte adhesion, morphology, and survival.

  8. LIM (显示 PDLIM5 蛋白) 5 domain of PINCH1 interacts with Rsu-1 (显示 RSU1 蛋白) in mammalian cells and functions, in part, by altering cell adhesion.

  9. The PINCH1 is composed of 5 LIM domains, binds ILK and locates to integrin-mediated adhesion sites, and PINCH1 is for integrin function, actin organization, cell-cell adhesion and endodermal cell survival during the implanting of mouse embryos.

  10. PICH1, Ilk (显示 ILK 蛋白) and alpha-parvin (显示 PARVA 蛋白) form a complex to costameres in neonatal mouse ventricular myocytes. This complex is stimulated by fibronectins and phenylephrine, and by both by drug synergism, to regulate cardiac myocyte hypertrophy.

蛋白简介LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1)

蛋白简介

The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with LIMS1

  • LIM zinc finger domain containing 1 (LIMS1)
  • LIM zinc finger domain containing 1 (Lims1)
  • LIM and senescent cell antigen-like domains 1 (Lims1)
  • 2310016J22Rik 蛋白
  • 4921524A02Rik 蛋白
  • AI507642 蛋白
  • AU021743 蛋白
  • AW551584 蛋白
  • C430041B13Rik 蛋白
  • Lims1l 蛋白
  • LIMS3 蛋白
  • LIMS3L 蛋白
  • PINCH 蛋白
  • PINCH-1 蛋白
  • Pinch1 蛋白
  • RGD1560732 蛋白

Protein level used designations for LIMS1

LIM and senescent cell antigen-like-containing domain protein 1 , particularly interesting new Cys-His protein 1 , renal carcinoma antigen NY-REN-48

GENE ID SPECIES
3987 Homo sapiens
499443 Rattus norvegicus
414880 Gallus gallus
474540 Canis lupus familiaris
100511559 Sus scrofa
540281 Bos taurus
110829 Mus musculus
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