LIM Domain Binding 3 (LDB3) ELISA试剂盒

LDB3 encodes a PDZ domain-containing protein. 再加上,我们可以发LIM Domain Binding 3 Protein 抗体 (65)LIM Domain Binding 3 Protein 蛋白 (5)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
 LDB3 LDB3 11155 O75112
小鼠 LDB3 LDB3 24131 Q9JKS4
大鼠 LDB3 LDB3 498587  
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适于 LIM Domain Binding 3 Protein 相互作用对的更多 ELISA 试剂盒

Human LIM Domain Binding 3 (LDB3) interaction partners

  1. this is the first family with Arrhythmogenic right ventricular cardiomyopathy where a mutation in LDB3 is associated with Arrhythmogenic right ventricular cardiomyopathy

  2. Study identified abnormal inclusion of LDB3 exon 11 specific to myotonic dystrophy type at the RNA and protein level; inclusion changed the affinity of LDB3 for PKC, indicating that exon 11 may contribute to the activation of PKC in DM1

  3. results show that MFM-associated ZASP mutations in the actin-binding domain have deleterious effects on the core structure of the Z-discs in skeletal muscle.

  4. Z-band alternatively spliced PDZ motif protein (ZASP) is the major O-linked beta-N-acetylglucosamine-substituted protein in human heart myofibrils

  5. This results of this indicted that One patient harbored the missense mutation c.1719G>A (p.V566M) in the ZASP gene.

  6. ZASP1 can form protein complex with telethonin/T-Cap (显示 TCAP ELISA试剂盒) and Na(v)1.5. The left ventricular noncompaction-specific ZASP1 mutation can cause loss of function of Na(v)1.5, without significant alteration of the cytoskeletal protein (显示 ACTN1 ELISA试剂盒) complex.

  7. TNNT3 and LDB3 showed abnormal splicing and appeared more pronounced in myotonic dystrophies type 2 relative to myotonic dystrophies type 1.

  8. the D626N mutation of Cypher/ZASP increases the affinity of the LIM (显示 PDLIM5 ELISA试剂盒) domain for protein kinase C (显示 PKC ELISA试剂盒), which may be related to pathogenesis of dilated cardiomyopathy

  9. ZASP/Cypher internal fragments containing either ZM exon 4 or 6 co-localized with alpha-actinin (显示 ACTN1 ELISA试剂盒) in cultured myoblasts and nonmuscle cells.

  10. ZASP/Cypher anchors PGM1 (显示 PGM1 ELISA试剂盒) to Z-disc under conditions of stress. The impaired binding of PGM1 (显示 PGM1 ELISA试剂盒) to ZASP/Cypher might be involved in the pathogenesis of dilated cardiomyopathy.

Mouse (Murine) LIM Domain Binding 3 (LDB3) interaction partners

  1. Cypher and ENH (显示 PDLIM5 ELISA试剂盒) redundantly play an essential role in sustaining Z-line structure from the earliest stages of cardiac function, and are redundantly required to maintain normal embryonic heart function and embryonic viability.

  2. results show that MFM-associated ZASP mutations in the actin-binding domain have deleterious effects on the core structure of the Z-discs in skeletal muscle.

  3. Results indicte that Cypher/ZASP interacted with the regulatory subunit RIIalpha of PKA.

  4. Data demonstrated that the Z-disk proteins, ZASP, titin (显示 TTN ELISA试剂盒) and vinculin (显示 VCL ELISA试剂盒) preferentially bind to alpha-actinin-2 (显示 ACTN2 ELISA试剂盒).

  5. Deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy.

  6. mutations of a structural/cytoskeletal protein (显示 ADD3 ELISA试剂盒), such as ZASP, lead to cardiac functional and electric abnormalities.

  7. Cypher isoforms are developmentally regulated in both skeletal and cardiac muscle

  8. Cypher plays a pivotal role in adult cardiac structure and function through protein-protein interactions with other Z-line proteins.

LIM Domain Binding 3 Protein (LDB3) 抗原简介

Antigen Summary

This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified\; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains.

Gene names and symbols associated with LDB3

  • LIM domain binding 3b (ldb3b) 抗体
  • LIM domain binding 3 S homeolog (ldb3.S) 抗体
  • LIM domain binding 3 (ldb3) 抗体
  • LIM domain binding 3 (LDB3) 抗体
  • LIM domain binding 3 (Ldb3) 抗体
  • AW742271 抗体
  • CMD1C 抗体
  • CYPHER 抗体
  • LDB3 抗体
  • ldb3l 抗体
  • LDB3Z1 抗体
  • LDB3Z4 抗体
  • LVNC3 抗体
  • MFM4 抗体
  • MGC52706 抗体
  • MGC75668 抗体
  • ORACLE 抗体
  • PDLIM6 抗体
  • RGD1564875 抗体
  • wu:fi31d08 抗体
  • ZASP 抗体
  • zgc:55814 抗体

Protein level used designations for LDB3

LIM domain binding 3 , LIM domain binding 3 like , LIM domain-binding protein 3 , PDZ and LIM domain 6 , Z-band alternatively spliced PDZ-motif protein , protein cypher , PDZ-LIM domain protein , cypher , oracle protein , protein oracle

GENE ID SPECIES
334100 Danio rerio
379929 Xenopus laevis
394699 Xenopus (Silurana) tropicalis
697140 Macaca mulatta
100348927 Oryctolagus cuniculus
100582910 Nomascus leucogenys
11155 Homo sapiens
536781 Bos taurus
24131 Mus musculus
498587 Rattus norvegicus
479269 Canis lupus familiaris
100151883 Sus scrofa
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