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KAT8 encodes a member of the MYST histone acetylase protein family. 再加上，我们可以发K(lysine) Acetyltransferase 8 抗体 (65) 和 K(lysine) Acetyltransferase 8 蛋白 (4)和数多这个蛋白质的别的产品。
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These findings provide insight into the regulation of LSD1 (显示 KDM1A ELISA试剂盒) and Epithelial-to-Mesenchymal Transition (EMT (显示 ITK ELISA试剂盒)) and identify MOF as a critical suppressor of EMT (显示 ITK ELISA试剂盒) and tumor progression.
This work identifies MOF as a key regulator of cellular stress response in glomerular podocytes.
recent results indicate MOF is an upstream regulator of the ATM (ataxia-telangiectasia mutated (显示 ATM ELISA试剂盒)) protein, the loss of which is responsible for ataxia telangiectasia (AT). ATM (显示 ATM ELISA试剂盒) is a key regulatory kinase that interacts with and phosphorylates multiple substrates that influence critical, cell-cycle control and DNA damage repair pathways in addition to other pathways.
Histone acetyltransferase (显示 HAT ELISA试剂盒) activity of MOF is required to sustain MLL (显示 MLL ELISA试剂盒)-AF9 (显示 MLLT3 ELISA试剂盒) leukemia and may be important for multiple AML (显示 RUNX1 ELISA试剂盒) subtypes.
our findings reveal that TET1 forms a complex with hMOF to modulate its function and the level of H4K16Ac ultimately affect gene expression and DNA repair.
these studies point to the critical and specific role of hMOF Lys (显示 LYZ ELISA试剂盒)-274 autoacetylation in hMOF stability and cognate substrate acetylation and argues that binding of Ac-CoA to hMOF likely drives Lys (显示 LYZ ELISA试剂盒)-274 autoacetylation for subsequent cognate substrate acetylation.
MOF is a dual-transcriptional regulator of nuclear and mitochondrial genomes connecting epigenetics and metabolism.
MOF is highly enriched in induced pluripotent stem cells (iPSCs), and MOF expression is upregulated during the reprogramming process. The ectopic expression of MOF promotes reprogramming. MOF affects Wdr5 (显示 WDR5 ELISA试剂盒) and endogenous Oct4 (显示 POU5F1 ELISA试剂盒) expression.
Along with the PHF20/MOF complex, G9a (显示 EHMT2 ELISA试剂盒) links the crosstalk between ERalpha (显示 ESR1 ELISA试剂盒) methylation and histone acetylation that governs the epigenetic regulation of hormonal gene expression.
Data found downregulation of hMOF in gastric cancer cells and tissues. Declined hMOF expression, but not high level of HDAC4 (显示 HDAC4 ELISA试剂盒), may account for global histone H4K16ac suggesting that loss of hMOF expression may be involved in gastric cancer progression.
demonstrate that KAT8 is essential for female fertility by regulating antioxidant gene expression and identify KAT8 as the first histone acetyltransferase (显示 HAT ELISA试剂盒) with an essential function in oogenesis
MOF is a developmental-stage-specific chromatin regulator found to be essential for adult but not early fetal hematopoiesis.
STAT5B (显示 STAT5B ELISA试剂盒) and MOF work as negative regulators in adipogenesis.
NSL and MSL HAT (显示 HAT ELISA试剂盒) complexes differentially regulate specific sets of expressed genes in mESCs and during differentiation
cardiac-specific MOF overexpression protected mice from transverse aortic constriction-induced cardiac hypertrophy, with reduced radios of heart weight/body weight, decreased left ventricular wall thickness and increased fractional shortening.
Mof plays a critical role in T-cell differentiation and that depletion of Mof in T cells reduces T-cell numbers and, by an undefined mechanism, induces genomic instability in B cells through bystander mechanism.
Depletion of MOF in mouse embryonic stem cells causes a specific decrease in expression of a subset of X-linked genes.
the histone acetyltransferase Mof plays an essential role in the maintenance of ESC self-renewal and pluripotency
This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene.
MYST histone acetyltransferase 1
, histone acetyltransferase KAT8
, K(lysine) acetyltransferase 8
, probable histone acetyltransferase MYST1-like
, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1
, MYST protein 1
, lysine acetyltransferase 8
, probable histone acetyltransferase MYST1
, histone acetyltransferase MYST1
, ortholog of Drosophila males absent on the first (MOF)
, histone acetyltransferase Myst1