anti-Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) 抗体

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. 再加上,我们可以发ISCU 蛋白 (7)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
ISCU 23479 Q9H1K1
ISCU 288740  
ISCU 66383 Q9D7P6

antibodies-online.cn销售最多的anti-ISCU 抗体

Showing 10 out of 59 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-Iscu Antibody Titration: 1.0 ug/ml Positive Control: Rat Lung 100 μL Log in to see 24至29个工作日
¥3,074.65
详细
非结合性 WB ISCU Antibody (C-term) (ABIN1881467) western blot analysis in mouse lung tissue lysates (35 µg/lane). This demonstrates the ISCU antibody detected the ISCU protein (arrow). ISCU Antibody (C-term) (ABIN1881467) western blot analysis in mouse lung tissue lysates (35 µg/lane). This demonstrates the ISCU antibody detected the ISCU protein (arrow). 400 μL Log in to see 5至8个工作日
¥2,325.14
详细
小鼠 非结合性 IF, ELISA, WB Immunofluorescence of monoclonal antibody to NIFUN on HeLa cell. [antibody concentration 10 ug/ml] NIFUN monoclonal antibody (M01), clone 3B8-1C4 Western Blot analysis of NIFUN expression in HL-60 . 100 μg Log in to see 29至34个工作日
¥3,169.73
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Bat 非结合性 WB 50 μg Log in to see 29至35个工作日
¥5,538.93
详细
小鼠 非结合性 IF, WB Immunofluorescence of monoclonal antibody to NIFUN on HeLa cell (antibody concentration 10 µg/mL). NIFUN monoclonal antibody (M01), clone 3B8-1C4 Western Blot analysis of NIFUN expression in HL-60. 0.1 mg Log in to see 11至15个工作日
¥3,179.71
详细
非结合性 ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: ISCU Antibody [NBP2-14998] - Paraffin-embedded A549 xenograft, using antibody at 1:500 dilution. Immunocytochemistry/Immunofluorescence: ISCU Antibody [NBP2-14998] - Analysis of methanol-fixed HeLa, using antibody at 1:200 dilution. 0.1 mL Log in to see 26至33个工作日
¥3,655.56
详细
小鼠 非结合性 IHC, WB Immunohistochemistry: ISCU Antibody (4F5) [NBP2-45436] - Analysis of Carcinoma of Human pancreas tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Immunohistochemistry: ISCU Antibody (4F5) [NBP2-45436] - Analysis of Carcinoma of Human thyroid tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) 0.1 mL Log in to see 26至33个工作日
¥3,655.56
详细
大鼠 非结合性 WB Western Blot: ISCU Antibody [NBP1-74072] - Rat Lung Lysate 1ug/ml Gel Concentration 10-20% 100 μL Log in to see 26至33个工作日
¥3,655.56
详细
小鼠 非结合性 IHC (p), WB   100 μL Log in to see 29至35个工作日
¥4,989.82
详细
小鼠 非结合性 WB   100 μL Log in to see 29至35个工作日
¥4,989.82
详细

通过反应活性、应用领域、克隆类型和共轭标记 ISCU 抗体

特性 应用范围 宿主 克隆类型 标记
Human ,
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Rat (Rattus)


Mouse (Murine)


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引用最多的anti-ISCU 抗体

  1. Human Polyclonal ISCU Primary Antibody for WB - ABIN1881467 : Chan, Zhang, Hemann, Mahoney, Zweier, Loscalzo: MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. in Cell metabolism 2009 (PubMed)
    Show all 5 references for 1881467

  2. Human Monoclonal ISCU Primary Antibody for IF, ELISA - ABIN565100 : Heather, Cole, Tan, Ambrose, Pope, Abd-Jamil, Carter, Dodd, Yeoh, Schofield, Clarke: Metabolic adaptation to chronic hypoxia in cardiac mitochondria. in Basic research in cardiology 2012 (PubMed)

更多抗ISCU的相互作用对抗体

Human Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) interaction partners

  1. We have shown that ASO treatment diminished aberrant splicing and increased ISCU protein levels in both patient fibroblasts and patient myotubes in a concentration dependent fashion. Upon ASO treatment, levels of SDHB (显示 SDHB 抗体) in patient myotubular cell lines increased to levels observed in control myotubular cell lines

  2. The NFS1 (显示 NFS1 抗体)/ISD11 (显示 LYRM4 抗体) complex further interacts with scaffold protein (显示 HOMER1 抗体) ISCU and regulator protein frataxin (显示 FXN 抗体), thereby forming a quaternary complex for Fe-S cluster formation.

  3. Molecular dynamics flexible fitting of protein structures docked into the EM map of the model revealed a [FXN (显示 FXN 抗体)(42-210)]24.[NFS1 (显示 NFS1 抗体)]24.[ISD11 (显示 LYRM4 抗体)]24.[ISCU]24 complex, consistent with the measured 1:1:1:1 stoichiometry of its four components.

  4. ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 (显示 TP53 抗体) mutation.

  5. Thus, driven by acquired (hypoxia) or genetic causes, the miR (显示 MLXIP 抗体)-210-ISCU1/2 regulatory axis is a pathogenic lynchpin causing iron-sulfur deficiency and pulmonary hypertension.

  6. The core Fe-S biosynthetic enzymatic complex generated [2Fe-2S] cluster intermediates that converted to stable [2Fe-2S] clusters bound to uncomplexed ISCU2.

  7. IscU is a new substrate of MK2 (显示 KCNA2 抗体) both in Drosophila cells and in human cells

  8. Fe-S assembly protein (ISCU2) and frataxin (显示 FXN 抗体) convert substrates l-cysteine, ferrous iron, and electrons into Fe-S clusters.

  9. the G50E iron-sulfur cluster scaffold protein (显示 NFU1 抗体) (ISCU) mutation has a role in mitochondrial myopathy

  10. NFS1 (显示 NFS1 抗体) binds preferentially to the D-state of ISCU while mtHSP70 (显示 HSPA9 抗体) binds preferentially to the D-state of ISCU and HSC20 (显示 HSCB 抗体) binds preferentially to the S-state of ISCU.

Mouse (Murine) Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) interaction partners

  1. ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 (显示 TP53 抗体) mutation.

  2. IscU is a marginally stable protein at low ionic strength to the point that undergoes cold denaturation at around -8 degrees C with a corresponding dramatic decrease of enthalpy, which is consistent with the fluxional nature of the protein.

  3. mTORC1 associates with ISCU and phosphorylates ISCU at serine 14. This phosphorylation stabilized ISCU protein.

  4. Data show that complete loss of ISCU results in early embryonic death and confirm a fundamental role for ISCU in mammals.

  5. While IFN-gamma (显示 IFNG 抗体) alone induced Nfs1 (显示 NFS1 抗体) protein instability, LPS (显示 TLR4 抗体) triggered a delayed decline of Nfs1 (显示 NFS1 抗体), rather involving transcriptional events or mRNA instability.

ISCU 抗原简介

蛋白简介

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria.

Gene names and symbols associated with ISCU

  • iron-sulfur cluster assembly enzyme ISCU, mitochondrial (Iscu) 抗体
  • iron-sulfur cluster scaffold homolog (E. coli) (ISCU) 抗体
  • IscU iron-sulfur cluster scaffold homolog (E. coli) (iscu) 抗体
  • iron-sulfur cluster assembly enzyme (ISCU) 抗体
  • iron-sulfur cluster scaffold homolog (E. coli) (Iscu) 抗体
  • IscU iron-sulfur cluster scaffold homolog (E. coli) (Iscu) 抗体
  • 2310020H20Rik 抗体
  • AA407971 抗体
  • HML 抗体
  • hnifU 抗体
  • ISU2 抗体
  • Nifu 抗体
  • Nifun 抗体
  • RGD1309562 抗体
  • si:ch211-191d15.3 抗体
  • zC191D15.3 抗体

Protein level used designations for ISCU

iron-sulfur cluster assembly enzyme ISCU, mitochondrial , iron-sulfur cluster scaffold homolog (E. coli) , iron-sulfur cluster assembly enzyme , IscU iron-sulfur cluster scaffold homolog (E. coli) , NifU-like N-terminal domain containing , zC191D15.3 (novel protein with leucine-rich repeat domains) , IscU iron-sulfur cluster scaffold homolog , iron-sulfur cluster scaffold homolog , nifU-like N-terminal domain-containing protein , nifU-like protein , ISCU2

GENE ID SPECIES
409130 Apis mellifera
477527 Canis lupus familiaris
514789 Bos taurus
497179 Danio rerio
23479 Homo sapiens
288740 Rattus norvegicus
66383 Mus musculus
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