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The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. 再加上，我们可以发IL27 抗体 (194) 和 IL27 蛋白 (23)和数多这个蛋白质的别的产品。
Showing 10 out of 51 products:
Rat (Rattus) IL27 ELISA Kit for Sandwich ELISA - ABIN416127
Gao, Pang, Zhang, Li, Tu, Zhang, Niu, Xiong, Xiao, Zhao, Gao, Wang: Poria Attenuates Idiosyncratic Liver Injury Induced by Polygoni Multiflori Radix Praeparata. in Frontiers in pharmacology 2016
Human IL27 ELISA Kit for Sandwich ELISA - ABIN414441
Li, Zhang, Ge, Zhou, Qi, Ma, Xue, Zhou, Yang: Elevated interleukin-27 enhances the polarization of Th1/Tc1 cells and the production of proinflammatory cytokines in primary immune thrombocytopenia. in Human immunology 2012
Human IL27 ELISA Kit for Sandwich ELISA - ABIN365220
Le Texier, Thebault, Carvalho-Gaspar, Vignard, Merieau, Usal, Cuturi, Wood, Chiffoleau: Immunoregulatory function of IL-27 and TGF-?1 in cardiac allograft transplantation. in Transplantation 2012
IL-27 polymorphisms might play a protective role for the development of ulcerative colitis in the Mexican population
IL-27 stimulation activated STAT1 (显示 STAT1 ELISA试剂盒) and STAT3 (显示 STAT3 ELISA试剂盒) in HeLa and T98G cells, suggesting that IL-27 engages the STAT1 (显示 STAT1 ELISA试剂盒)/3 pathway, which then leads to the upregulation of IL-6 (显示 IL6 ELISA试剂盒), IP-10 (显示 CXCL10 ELISA试剂盒), and MIG (显示 CXCL9 ELISA试剂盒)
IL-27 and IL-37 limit the induction of particular T cell subsets along with cytokine responses in S. stercoralis infections, which suggest the importance of IL-27 and IL-37 in immune modulation in a chronic helminth infection.
IL-27 is a pivotal regulator in endometriotic immune tolerance by triggering Th17 cells to produce IL-10 (显示 IL10 ELISA试剂盒).
HIV and Tat (显示 TAT ELISA试剂盒) inhibit LPS (显示 IRF6 ELISA试剂盒)-induced IL-27 production in human macrophages via distinct mechanisms: Tat (显示 TAT ELISA试剂盒) through the inhibition of cIAP-1 (显示 BIRC2 ELISA试剂盒)-TRAF-6 (显示 TRAF6 ELISA试剂盒) and subsequent inhibition of PI3K (显示 PIK3CA ELISA试剂盒) and p38 (显示 CRK ELISA试剂盒) MAPKs, whereas HIV through the inhibition of p38 MAPK (显示 MAPK14 ELISA试剂盒) activation.
IL27 (显示 EBI3 ELISA试剂盒) recapitulates IFN-gamma (显示 IFNG ELISA试剂盒) responses in hepatocellular carcinoma cells, but is inhibited by IL6 (显示 IL6 ELISA试剂盒)-type cytokines.
These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta (显示 IL1B ELISA试剂盒) secretion levels triggered by dual LPS (显示 IRF6 ELISA试剂盒)-ATP stimulation.
IL-27 enhanced the cytotoxicity and suppressed the proliferation of ovarian cancer cells
the sIL (显示 PMEL ELISA试剂盒)-6R/p28 (显示 PSMD10 ELISA试剂盒) fusion protein (FP) upregulated IFN-lambda1 expression by increasing the binding abilities of c-Fos and activating transcription factor 1 (显示 AFT1 ELISA试剂盒) to the IFN-lambda1 promoter via the p38 MAPK (显示 MAPK14 ELISA试剂盒) signaling pathway; results demonstrate the important role of sIL (显示 PMEL ELISA试剂盒)-6R/p28 (显示 PSMD10 ELISA试剂盒) FP in mediating virus-induced type III IFN production.
These results identify IL-27 and its specific receptor IL27RA (显示 IL27RA ELISA试剂盒) as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection.
IL-27-induced Sca-1 (显示 Ly6a ELISA试剂盒)(+) T cells had increased expression of effector/memory-associated transcription factor T-bet, Eomes (显示 EOMES ELISA试剂盒) and Blimp1 (显示 PRDM1 ELISA试剂盒).
found that during respiratory virus infection the prototypic inflammatory cytokine IL-6 (显示 IL6 ELISA试剂盒) is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27
We demonstrate that IL-27-deficiency is linked to increased mucosal presence of ILC2 in a model of inflammatory lung disease. Moreover, IL-27-treatment inhibited ILC2 proliferation and cytokine production and significantly reduced their accumulation in vivo.
These data suggest a novel role of the sympathetic neuroendocrine system for the modulation of IL-27-dependent acute inflammation.
results identified a novel mechanism of action of IL-27 on Tregs in the context of cancers.
These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta (显示 IL1B ELISA试剂盒) secretion levels triggered by dual LPS (显示 TLR4 ELISA试剂盒)-ATP stimulation.
findings show that PGE2 inhibits IL-27 production in macrophages and in splenic conventional dendritic cells; and identify a novel pathway consisting of signaling through EP2/EP4-->induction of cAMP-->downregulation of IFN regulatory factor 1 expression and binding to the p28 IFN-stimulated response element site
these data provide the first evidence that IL-27 signals directly to B (显示 TDO2 ELISA试剂盒) cells promote GCs (显示 UGCG ELISA试剂盒) and support the role of IL-27 in lupus.
this study shows that IL-27 plays an important role in immune response and pathogen clearance during infection with Candida parapsilosis
Inhibition of IL-27p28 also enhanced the suppressive capacity of adoptively transferred CD4 (显示 CD4 ELISA试剂盒)(+) nTregs by increasing the stability of Foxp3 (显示 FOXP3 ELISA试剂盒) expression.
The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
IL-27 p28 subunit
, IL-27 subunit alpha
, interleukin 30
, interleukin-27 subunit alpha
, interluekin 27
, interleukin 27
, interleukin 27 p28 subunit