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The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. 再加上，我们可以发IL27 试剂盒 (51) 和 IL27 蛋白 (23)和数多这个蛋白质的别的产品。
Showing 10 out of 194 products:
Mouse (Murine) Monoclonal IL27 Primary Antibody for ICS, Neut - ABIN2689756
Hall, Silver, Hunter: The immunobiology of IL-27. in Advances in immunology 2012
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Mouse (Murine) Polyclonal IL27 Primary Antibody for WB - ABIN1043831
Pflanz, Timans, Cheung, Rosales, Kanzler, Gilbert, Hibbert, Churakova, Travis, Vaisberg, Blumenschein, Mattson, Wagner, To, Zurawski, McClanahan, Gorman, Bazan, de Waal Malefyt, Rennick, Kastelein: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. in Immunity 2002
Mouse (Murine) Monoclonal IL27 Primary Antibody for WB - ABIN1043835
Murugaiyan, Mittal, Weiner: Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. in Proceedings of the National Academy of Sciences of the United States of America 2010
Human Monoclonal IL27 Primary Antibody for CyTOF, FACS - ABIN4900122
Seyerl, Kirchberger, Majdic, Seipelt, Jindra, Schrauf, Stöckl: Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. in European journal of immunology 2010
IL-27 polymorphisms might play a protective role for the development of ulcerative colitis in the Mexican population
IL-27 stimulation activated STAT1 (显示 STAT1 抗体) and STAT3 (显示 STAT3 抗体) in HeLa and T98G cells, suggesting that IL-27 engages the STAT1 (显示 STAT1 抗体)/3 pathway, which then leads to the upregulation of IL-6 (显示 IL6 抗体), IP-10 (显示 CXCL10 抗体), and MIG (显示 CXCL9 抗体)
IL-27 and IL-37 limit the induction of particular T cell subsets along with cytokine responses in S. stercoralis infections, which suggest the importance of IL-27 and IL-37 in immune modulation in a chronic helminth infection.
IL-27 is a pivotal regulator in endometriotic immune tolerance by triggering Th17 cells to produce IL-10 (显示 IL10 抗体).
HIV and Tat (显示 TAT 抗体) inhibit LPS (显示 IRF6 抗体)-induced IL-27 production in human macrophages via distinct mechanisms: Tat (显示 TAT 抗体) through the inhibition of cIAP-1 (显示 BIRC2 抗体)-TRAF-6 (显示 TRAF6 抗体) and subsequent inhibition of PI3K (显示 PIK3CA 抗体) and p38 (显示 CRK 抗体) MAPKs, whereas HIV through the inhibition of p38 MAPK (显示 MAPK14 抗体) activation.
IL27 (显示 EBI3 抗体) recapitulates IFN-gamma (显示 IFNG 抗体) responses in hepatocellular carcinoma cells, but is inhibited by IL6 (显示 IL6 抗体)-type cytokines.
These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta (显示 IL1B 抗体) secretion levels triggered by dual LPS (显示 IRF6 抗体)-ATP stimulation.
IL-27 enhanced the cytotoxicity and suppressed the proliferation of ovarian cancer cells
the sIL (显示 PMEL 抗体)-6R/p28 (显示 PSMD10 抗体) fusion protein (FP) upregulated IFN-lambda1 expression by increasing the binding abilities of c-Fos and activating transcription factor 1 (显示 AFT1 抗体) to the IFN-lambda1 promoter via the p38 MAPK (显示 MAPK14 抗体) signaling pathway; results demonstrate the important role of sIL (显示 PMEL 抗体)-6R/p28 (显示 PSMD10 抗体) FP in mediating virus-induced type III IFN production.
These results identify IL-27 and its specific receptor IL27RA (显示 IL27RA 抗体) as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection.
IL-27-induced Sca-1 (显示 Ly6a 抗体)(+) T cells had increased expression of effector/memory-associated transcription factor T-bet, Eomes (显示 EOMES 抗体) and Blimp1 (显示 PRDM1 抗体).
found that during respiratory virus infection the prototypic inflammatory cytokine IL-6 (显示 IL6 抗体) is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27
We demonstrate that IL-27-deficiency is linked to increased mucosal presence of ILC2 in a model of inflammatory lung disease. Moreover, IL-27-treatment inhibited ILC2 proliferation and cytokine production and significantly reduced their accumulation in vivo.
These data suggest a novel role of the sympathetic neuroendocrine system for the modulation of IL-27-dependent acute inflammation.
results identified a novel mechanism of action of IL-27 on Tregs in the context of cancers.
These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta (显示 IL1B 抗体) secretion levels triggered by dual LPS (显示 TLR4 抗体)-ATP stimulation.
findings show that PGE2 inhibits IL-27 production in macrophages and in splenic conventional dendritic cells; and identify a novel pathway consisting of signaling through EP2/EP4-->induction of cAMP-->downregulation of IFN regulatory factor 1 expression and binding to the p28 IFN-stimulated response element site
these data provide the first evidence that IL-27 signals directly to B (显示 TDO2 抗体) cells promote GCs (显示 UGCG 抗体) and support the role of IL-27 in lupus.
this study shows that IL-27 plays an important role in immune response and pathogen clearance during infection with Candida parapsilosis
Inhibition of IL-27p28 also enhanced the suppressive capacity of adoptively transferred CD4 (显示 CD4 抗体)(+) nTregs by increasing the stability of Foxp3 (显示 FOXP3 抗体) expression.
The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
IL-27 p28 subunit
, IL-27 subunit alpha
, interleukin 30
, interleukin-27 subunit alpha
, interluekin 27
, interleukin 27
, interleukin 27 p28 subunit