Interleukin 18 Binding Protein 蛋白 (IL18BP)

The protein encoded by IL18BP functions as an inhibitor of the proinflammatory cytokine, IL18. 再加上,我们可以发IL18BP 抗体 (126)IL18BP 试剂盒 (32)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
IL18BP 16068 Q9Z0M9
IL18BP 10068 O95998
IL18BP 84388  

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Showing 10 out of 26 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
HOST_HEK-293 Cells His tag 200 μg Log in to see 24至29个工作日
¥2,786.66
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人细胞 His tag 100 μg Log in to see 14至15个工作日
¥2,465.63
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大肠杆菌(E. Coli) His tag 100 μg Log in to see 33至41个工作日
¥3,331.12
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 68至72个工作日
¥136,777.64
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 68至72个工作日
¥136,777.64
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大肠杆菌(E. Coli) 非结合性 100 μg Log in to see 24至29个工作日
¥3,774.22
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人细胞 小鼠 His tag 100 μg Log in to see 14至15个工作日
¥2,465.63
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大肠杆菌(E. Coli) His tag 100 μg Log in to see 9至12个工作日
¥3,296.24
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大肠杆菌(E. Coli) 大鼠 His tag 100 μg Log in to see 9至12个工作日
¥3,640.98
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HOST_Mammalian Cells Fc Tag   50 μg Log in to see 26至30个工作日
¥3,870.27
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IL18BP 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine) , ,

Human , , , , , , , ,
, , ,
Rat (Rattus)

引用最多的IL18BP 蛋白

  1. Human IL18BP Protein expressed in Human Cells - ABIN2002664 : Mazodier, Marin, Novick, Farnarier, Robitail, Schleinitz, Veit, Paul, Rubinstein, Dinarello, Harlé, Kaplanski: Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome. in Blood 2005 (PubMed)
    Show all 5 references for 2002664

  2. Human IL18BP Protein expressed in HEK-293 Cells - ABIN2181348 : Novick, Kim, Fantuzzi, Reznikov, Dinarello, Rubinstein: Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. in Immunity 1999 (PubMed)
    Show all 2 references for 2181348

  3. Human IL18BP Protein expressed in Escherichia coli (E. coli) - ABIN1098760 : Fujita, Shimizu, Fuke, Satomura, Abe, Kaizu, Matsumoto, Soma: Serum interleukin-18 binding protein increases with behavior different from IL-18 in patients with diabetic nephropathy. in Diabetes research and clinical practice 2011 (PubMed)
    Show all 2 references for 1098760

更多Interleukin 18 Binding Protein (IL18BP)互动伙伴

Rhesus Monkey Interleukin 18 Binding Protein (IL18BP) interaction partners

  1. A full-length cDNA of the rhesus IL-18BP (RhIL-18BP) from the spleen of rhesus macaques, was cloned and sequenced.

Rabbit Interleukin 18 Binding Protein (IL18BP) interaction partners

  1. Pressure overload, while enhancing IL-18 (显示 IL18 蛋白) and IL-18R expression in hypertrophied and failing hearts, markedly attenuated the level of expression of the endogenous IL-18 (显示 IL18 蛋白) antagonist IL-18BP.

Mouse (Murine) Interleukin 18 Binding Protein (IL18BP) interaction partners

  1. IL-18BP ameliorates cardiac ischemia/reperfusion injury in part through suppression of Th17 differentiation.

  2. Data show that IL-18bp acts as a sensor for IFN-gamma (显示 IFNG 蛋白) and can regulate both Th1 (显示 HAND1 蛋白) and Th17 responses in the CNS.

  3. Administratioan of murine IL-18BP at the time of the booster injection of bovine CII reduces the progressive severity of collagen-induced arthritis; both clinical disease activity and histological scores are decreased by 50%.

  4. functional polarization of Ag-specific CD4 (显示 CD4 蛋白)(+) Th2 cells entering the CNS during the accelerating phase of experimental autoimmune encephalomyelitis is flexible and dependent on IL-18 (显示 IL18 蛋白), which is overturned by IL-18 (显示 IL18 蛋白) binding protein

  5. IL-18 (显示 IL18 蛋白) and IL-18BP may have roles in testicular development, and also in the regulation of testicular functions under physiological conditions

  6. A single intravenous dose of recombinant mouse IL18BP decreased neointimal hyperplasia and improved arterial L/A ratios in an atherosclerotic balloon-injury animal model.

Human Interleukin 18 Binding Protein (IL18BP) interaction partners

  1. IL-18 (显示 IL18 蛋白), IL-18R and IL-18BP expression in eosinophil are involved in the inflammatory reaction of asthma.

  2. the inhibition of IL-18 (显示 IL18 蛋白) signaling by IL-18BPa may be involved in the development of pulmonary vascular involvement leading to pulmonary hypertension and modulate the systemic inflammation in systemic sclerosis

  3. The natural IL-18 (显示 IL18 蛋白) inhibitor IL-18BP further regulates IL-18 (显示 IL18 蛋白) activity in the extracellular environment. Review.

  4. imbalance of IL-18/IL-18BP ratio in IgA nephropathy especially in patients with arteriolar lesions

  5. IL-18 (显示 IL18 蛋白), IL-18BP, and IL-18R may have roles in the pathogenesis of epithelial ovarian carcinoma

  6. HPV16 E7 oncoprotein increases production of the IL18BP in keratinocytes.

  7. these data indicate that IL-18BP, which is produced in EOC in response to microenvironmental factors, may inhibit endogenous or exogenous IL-18 (显示 IL18 蛋白) activity

  8. Data suggest that the imbalance of IL-18 (显示 IL18 蛋白)/IL-18BP might play an important role in the pathogenesis of systemic juvenile idiopathic arthritis (SJIA) and it might go hand-in-hand with the severity of SJIA.

  9. Due to highly significant increases in circulating IL-18BP in schizophrenia compared to controls, the levels of free IL-18 (显示 IL18 蛋白) are not significantly different between schizophrenic groups.

  10. Imbalance between IL-18 (显示 IL18 蛋白) and IL-18BP may play an important role in pathogenesis of idiopathic thrombocytopenic purpura.

蛋白简介IL18BP

蛋白简介

The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with IL18BP

  • interleukin 18 binding protein (IL18BP)
  • interleukin 18 binding protein (LOC100340371)
  • interleukin 18 binding protein (Il18bp)
  • Igifbp 蛋白
  • IL-18BP 蛋白
  • IL18BP 蛋白
  • IL18BPa 蛋白
  • MC54L 蛋白

Protein level used designations for IL18BP

interleukin 18 binding protein , interferon gamma inducing factor binding protein , interferon gamma-inducing factor-binding protein , interleukin-18-binding protein , IL-18BP , MC51L-53L-54L homolog gene product , tadekinig-alfa , interleukin-18 binding protein

GENE ID SPECIES
476818 Canis lupus familiaris
748234 Pan troglodytes
100144607 Macaca mulatta
100340371 Oryctolagus cuniculus
16068 Mus musculus
10068 Homo sapiens
84388 Rattus norvegicus
617470 Bos taurus
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