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IRF6 encodes a member of the interferon regulatory transcription factor (IRF) family. 再加上，我们可以发IRF6 抗体 (98) 和 IRF6 蛋白 (9)和数多这个蛋白质的别的产品。
CCL5 (显示 CCL5 ELISA试剂盒) and CXCL11 (显示 CXCL11 ELISA试剂盒) expression were also induced in response to the activation of the PKC pathway, and gene silencing experiments indicated that their inducible expression was dependent on RIPK4 (显示 RIPK4 ELISA试剂盒) and IRF6. Moreover, gene reporter assays suggested that RIPK4 (显示 RIPK4 ELISA试剂盒) induces CCL5 (显示 CCL5 ELISA试剂盒) and CXCL11 (显示 CXCL11 ELISA试剂盒) expression by stimulating the transactivation of their promoters by IRF6.
IRF6 is aberrantly silenced by DNA methylation (显示 HELLS ELISA试剂盒) of the 5' IRF6 CGI in melanoma
In all three affecteds the known pathogenic mutation c.265A>G, p.Lys89Glu in IRF6 was identified. While inter- as well as intra-familial variability has been described in IRF6-related disorders, the occurrence of a typical Van (显示 TNIP1 ELISA试剂盒) der (显示 GDF3 ELISA试剂盒) Woude Syndrome without any other anomalies as well as a diagnosis of Popliteal pterygium syndrome in the same family is rare.
Association between IRF6 and 8q24 polymorphisms and nonsyndromic cleft lip with or without cleft palate
Here, we demonstrate the protein functions of human IRF6 missense gene variants could be rapidly assessed in detail by their abilities to rescue the irf6 -/- phenotype in zebrafish through variant mRNA microinjections at the one-cell stage.
The data presented suggest an important role for cytoplasmic IRF6 in regulating the availability or localization of the NME1 (显示 NME1 ELISA试剂盒)/2 complex and thus the dynamic behavior of epithelia during lip/palate development.
IRF6 dysregulation may be involved in the development of Vulvar Squamous Cell Carcinoma from vulvar lichen sclerosus (VLS). Methylation of the IRF6 promoter may be a marker of cancer risk in patients with VLS.
Here, the authors have established that IRF6 promotes the differentiation of oral keratinocytes in response to Porphyromonas gingivalis.
It has been shown that pathogenic IRF6 mutations are likely to occur in a small fraction (~0.3%) of individuals with apparent nonsyndromic orofacial cleft, across multiple ethnic groups.
The 8q24 region plays a role in cleft lip/palate and the IRF6 G/A haplotype (rs2235371/rs642961) increases the risk for oral cleft in the Brazilian population.
Fish IRF6 is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 (显示 MYD88 ELISA试剂盒) and TBK1 (显示 TBK1 ELISA试剂盒), suggesting that differences in the IRF6 regulation pattern exist between lower and higher vertebrates.
Authors report that Kruppel-like factor 17 (Klf17 (显示 KLF17 ELISA试剂盒)), like Grhl3 (显示 GRHL3 ELISA试剂盒), acts downstream of Irf6 in this network in zebrafish periderm.
In zebrafish periderm, grainyhead-like 3 (grhl3 (显示 GRHL3 ELISA试剂盒)) (an ancient regulator of the epidermal permeability barrier), was identified as acting downstream of Irf6. Simultaneous inhibition of grhl1 (显示 GRHL1 ELISA试剂盒) and grhl3 (显示 GRHL3 ELISA试剂盒) disrupted periderm differentiation in zebrafish.
analysis of zebrafish expression of IRF6
These experiments reveal a conserved role for maternally-encoded Irf6 in differentiation of a simple epithelium in X. laevis and D. rerio.
Filiform papillae thus develop through distinct molecular mechanisms between the regions of tongue dorsum in the medio-lateral axis, with some filiform papillae developing under the control of Ikkalpha (显示 CHUK ELISA试剂盒) and Irf6.
IRF6 suppresses PPARgamma (显示 PPARG ELISA试剂盒) through binding IRF (显示 TRIM63 ELISA试剂盒) recognition sites located upstream of the PPARgamma (显示 PPARG ELISA试剂盒) coding region. Taken together, the results suggest that an IRF6/PPARgamma (显示 PPARG ELISA试剂盒) regulatory axis suppresses anti-inflammatory responses in bone marrow-derived macrophages and provides references for future study addressing dysregulated metabolic and immunologic homeostasis of obese adipose tissue.
Irf6 and RTK signaling interact in regulating periderm differentiation and function, as well as provide a rationale to screen for epistatic interactions between variants in IRF6 and RTK signaling pathway genes in human orofacial clefting populations.
These data provide the first mechanistic insight into the heightened caries susceptibility associated with CLP (显示 HAPLN1 ELISA试剂盒) and indicate a direct role for the major CLP (显示 HAPLN1 ELISA试剂盒) gene Irf6 in salivary gland development and a significant role in regulating oral immunity in mice.
that downregulation of interferon regulatory factor 6 affords protection against TNI (显示 TNNI2 ELISA试剂盒) through Akt (显示 AKT1 ELISA试剂盒)-eNOS (显示 NOS3 ELISA试剂盒) pathway-mediated antioxidative and anti-inflammatory activity
Irf6 is required for resistance to Lipopolysaccharides-induced endotoxic shock. In addition, Irf6-deficient bone marrow-derived neutrophils exhibited increased chemotactic index and velocity compared with wild-type cells in vitro.
TGFbeta3 increases IRF6 expression and subsequently regulates SNAI2 expression; IRF6 appears to regulate epithelial mesenchymal transition during palatal fusion via SNAI2.
Pvrl1 (显示 PVRL1 ELISA试剂盒) is a bona fide target gene of the transcription factor p63 (显示 CKAP4 ELISA试剂盒), whereas Pvrl4 (显示 PVRL4 ELISA试剂盒) regulation is linked to epidermal differentiation and is under Irf6
Data suggest that Irf6 functions through the RhoA (显示 RHOA ELISA试剂盒) pathway to regulate cellular migration.
These results support a role for IRF6 in brain morphometry and provide evidence for a potential genetic link to abnormal brain development in orofacial clefting.
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.
interferon regulatory factor 6
, interferon regulatory factor 6-like