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Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011].. 再加上，我们可以发IDO2 蛋白 (8) 和 IDO2 试剂盒 (6)和数多这个蛋白质的别的产品。
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Human Polyclonal IDO2 Primary Antibody for ELISA, IHC (fro) - ABIN4321036
Zuliani, Saiagh, Knol, Esbelin, Dréno: Fetal fibroblasts and keratinocytes with immunosuppressive properties for allogeneic cell-based wound therapy. in PLoS ONE 2013
Show all 2 Pubmed References
Mouse (Murine) Monoclonal IDO2 Primary Antibody for ELISA, ICC - ABIN4321038
Metz, Duhadaway, Rust, Munn, Muller, Mautino, Prendergast: Zinc protoporphyrin IX stimulates tumor immunity by disrupting the immunosuppressive enzyme indoleamine 2,3-dioxygenase. in Molecular cancer therapeutics 2010
Mouse (Murine) Polyclonal IDO2 Primary Antibody for IHC, ELISA - ABIN1043908
Wolff, Driever, Erdlenbruch, Kortmann, Rutkowski, Pietsch, Parker, Metz, Gnekow, Kramm: Intensive chemotherapy improves survival in pediatric high-grade glioma after gross total resection: results of the HIT-GBM-C protocol. in Cancer 2010
High IDO2 expression is associated with Colorectal Cancer.
High IDO2 expression is associated with cervical cancer.
functional importance of IDO (显示 IDO1 抗体) enzymes in human Crohn's disease
Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1 (显示 IDO1 抗体)
These results demonstrate that IDO2 plays a novel role as a negative regulator of IDO1 (显示 IDO1 抗体) by competing for heme-binding with IDO1 (显示 IDO1 抗体).
The IDO2 is now known to catalyze the first and rate-limiting step in the catabolism of tryptophan along a relative newcomer to the kynurenine pathway field.
Multiple-scattering (MS) analysis of EXAFS data on met-indoleamine 2,3-dioxygenase-2 (IDO2) and analysis of XANES have provided the first direct structural information about the axial donor ligands of the iron center for this recently discovered protein.
IDO2 is expressed in both mDCs and plasmacytoid DCs and is not modulated by PGE2. IDO2 expression is constitutively, stably expressed in steady-state conditions and may contribute to the homeostatic tolerogenic capacity of DCs.
Indoleamine2,3-dioxygenase and tryptophanyl-tRNA synthetase (显示 WARS 抗体) may play critical roles in the immune pathogenesis of chronic kidney disease.
Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 (显示 IDO1 抗体) and IDO2) and discovery of selective IDO1 (显示 IDO1 抗体) inhibitors.
Gene silencing of indoleamine 2,3-dioxygenase 2 in melanoma cells induces apoptosis through the suppression of NAD+ and inhibits in vivo tumor growth.
Findings suggest non-redundant neurophysiological roles for indoleamine 2,3-dioxygenase 1 (显示 IDO1 抗体), indoleamine 2,3-dioxygenase 2 and tryptophan 2,3-dioxygenase (显示 TDO2 抗体) in modulating brain activities and metabolism.
The IDO2-deficient B cells lacked the ability to upregulate the costimulatory marker CD40 (显示 CD40 抗体), suggesting IDO2 acts at the T-B cell interface to modulate the potency of T cell help needed to promote autoantibody production.
Targeting IDO2 with a monoclonal antibody inhibits autoreactive B and T cell activation and alleviates joint inflammation in two well-characterized preclinical models of arthritis.
Indoleamine-2,3-dioxygenase (IDO (显示 IDO1 抗体)) production by Plasmacytoid dendritic cells (pDCs)is necessary to confer suppressive function to T-Cells, Regulatory (Tregs) in experimental autoimmune encephalomyelitis (EAE).
Ido2 may be important for mouse embryo implantation and decidualization.
The data showed that there is not significant effect of IDO1 (显示 IDO1 抗体) or TDO2 (显示 TDO2 抗体) on mortality in pneumococcal meningitis.
IDO2 is critical for IDO1 (显示 IDO1 抗体)-mediated T-cell regulation and exerts a non-redundant function in inflammation.
Deletion of Ido1 (显示 IDO1 抗体) and reduced mRNA expression for Ido2 neither affected the concentration of the downstream metabolites of tryptophan nor mRNA expression for downstream genes on the kynurenine pathway in inguinal lymph nodes.
results provide important insights into IDO2 function by defining its pathogenic contributions to autoantibody-mediated autoimmunity.
Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007
indoleamine 2,3-dioxygenase 2
, indoleamine 2,3-dioxygenase 2-like
, indoleamine 2,3-dioxygenase-like 1 protein
, indoleamine 2,3-dioxygenase-like protein 1
, indoleamine-pyrrole 2,3 dioxygenase-like 1
, indoleamine-pyrrole 2,3-dioxygenase-like protein 1