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Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. 再加上，我们可以发HIST1H1C 蛋白 (5) 和 HIST1H1C 试剂盒 (1)和数多这个蛋白质的别的产品。
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BRG1 (显示 SMARCA4 抗体) participates in gene repression by interacting with H1.2, facilitating its deposition and stabilizing nucleosome positioning around the transcription start site.
Results show that histones H1.2 and H1.4 were observed in MDA-MB-231 metastatic breast cancer cells. The phosphorylation at S173 of histone H1.2 and S172, S187, T18, T146, and T154 of H1.4 significantly increases during M phase suggesting that these events are cell cycle-dependent. Also, the study reports the observation of the H1.2 SNP variant A18V in MCF-10A cells.
Histone H1.2-T165 post translational modifications are dispensable for chromatin binding and cell proliferation while the H1.4-K26 (显示 KRT26 抗体) modifications are essential for proper cell cycle progression.
H1.2 interacts with Cul4A (显示 CUL4A 抗体) and PAF1 (显示 PEX2 抗体) to activate developmental regulatory genes.
H1.2 is less abundant than other histone H1 (显示 H1F0 抗体) variants at the transcription start sites of inactive genes, and promoters enriched in H1.2 are different from those enriched in other histone H1 (显示 H1F0 抗体) variants and tend to be repressed.
Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma.
These data suggest that p53 (显示 TP53 抗体) acetylation-H1.2 phosphorylation cascade serves as a unique mechanism for triggering p53 (显示 TP53 抗体)-dependent DNA damage response pathways.
confirmed N-terminal acetylation on all isoforms plus a single internal acetylation site; phosphorylation sites were located on peptides containing the cyclin dependent kinase (显示 CDK1 抗体) (CDK (显示 CDK4 抗体)) consensus motif
The binding of histone H1 (显示 H1F0 抗体) to a general amyloid-like motif indicates that histone H1 (显示 H1F0 抗体) may play an important common role in diseases associated with amyloid-like fibrils.
Histone H1.2 was translocated from the nucleus to the mitochondria after treatment with bleomycin and co-localized with Bak (显示 BAK1 抗体) in mitochondria.
Histone H1c gene expression is developmentally up-regulated to promote facultative heterochromatin in mature rod photoreceptors.
These results integrate the localization of an understudied type of chromatin proteins, namely the H1 variants, into the epigenome map of mouse ESCs (显示 NR2E3 抗体).
The N-terminal domain contributes toward the differential chromatin binding affinity, whereas the C-terminal domain contributes toward distinct nucleosomal interface of isotypes H10 (显示 H1F0 抗体) and H1c.
The amount of the linker histone H1c is strongly reduced in nuclear extracts of SCA7 (显示 ATXN7 抗体) retinas and that the cellular distribution of H1c is particularly altered in the facultative heterochromatin compartment.
The modular pattern of DNA methylation (显示 HELLS 抗体) in the Ig heavy chain locus and histone modifications appears to be determined by at least 2 factors: the B-cell-specific transcription factor Pax5 (显示 PAX5 抗体) and linker histone H1 (显示 H1F0 抗体).
These observations reveal a mode of p53 (显示 TP53 抗体) regulation mediated by CHD8 (显示 CHD8 抗体), which may set a threshold for induction of apoptosis during early embryogenesis by counteracting p53 (显示 TP53 抗体) function through recruitment of histone H1 (显示 H1F0 抗体).
H1 isoforms H1.0, H1.1, and H1.2 are non-responsive to hormone whereas prolonged dexamethasone treatment effectively dephosphorylated the H1.3, H1.4, and H1.5 isoforms
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
, histone H1.1
, histone H1.2
, histone H1d
, histone 1, H1c
, histone H1.11L
, H1 histone family, member 2
, histone H1c
, histone H1s-1
, H1 VAR.1
, histone H1
, H1 histone family, member 4
, Histone 1d
, histone H1.4