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The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. 再加上，我们可以发Hemoglobin Subunit beta 蛋白 (200) 和 Hemoglobin Subunit beta 试剂盒 (28)和数多这个蛋白质的别的产品。
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Human Monoclonal Hemoglobin Subunit beta Primary Antibody for ELISA, WB - ABIN561229
Xie, Ren, Zhang, Guo, Wang, Wang, Lin, Gong, Li, Huang, Zeng, Zeng: Restoration of the balanced alpha/beta-globin gene expression in beta654-thalassemia mice using combined RNAi and antisense RNA approach. in Human molecular genetics 2007
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Human Monoclonal Hemoglobin Subunit beta Primary Antibody for IHC (p), ELISA - ABIN561230
Ishikawa, Ohlmeier, Salmenkivi, Myllärniemi, Rahman, Mazur, Kinnula: Hemoglobin ? and ? are ubiquitous in the human lung, decline in idiopathic pulmonary fibrosis but not in COPD. in Respiratory research 2010
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Human Polyclonal Hemoglobin Subunit beta Primary Antibody for ELISA, WB - ABIN561228
Martins, Rino, Carvalho, Carvalho, Yoshida, Klose, de Almeida, Carmo-Fonseca: Spliceosome assembly is coupled to RNA polymerase II dynamics at the 3' end of human genes. in Nature structural & molecular biology 2011
Pan (显示 SUPT6H 抗体) troglodytes and Pongo pygmaeus were screened for mutations in the beta-globin gene (exons 1, 2, and 3) for suspected thalassemia.
We found no evidence of the major deleterious mutations at HBB in chimpanzees that confer resistance to malaria caused by Plasmodium falciparum nor evidence of long-term balancing selection at these loci.
Data indicate that on incubating hemoglobin with glyoxal for 0-20 days, advanced glycation end products (AGEs) were detected on day 20.
In this study, hemoglobin subunit beta was identified as a classical swine fever virus capsid protein-binding protein by glutathione S-transferase (显示 GSTa2 抗体) pulldown and subsequent mass spectrometry analysis of PK-15 cells.
In conclusion, in this work we demonstrated that HBB is expressed by breast cancer cells, its expression is correlated with tumour aggressiveness in humans and its forced overexpression enhances breast cancer cell aggressiveness in vitro and in vivo.
NF-E2 (显示 NFE2 抗体), TAL1 (显示 TAL1 抗体) and KLF1 (显示 KLF1 抗体), all activators play a primary role in HSs (显示 GFER 抗体) formation in the LCR
Five different beta-globin haplotypes were linked to sickle hemoglobin alleles in Mazandaran province.
2 cases of Polish patients with hereditary hemolytic anemia suspected of thalassemia were studied; identified 2 different frameshift mutations positioned in the third exon of HBB; results show a lack of natural stop codon due to the frameshift in exon 3 of beta-globin gene causes rapid degradation of its mRNA and indicate existence of novel surveillance pathway
Our work suggested a novel function for HBB as a theranostic molecule: an innate antimetastasis factor with potential utility as an anticancer drug and a biomarker signaling the presence of clinically undetectable metastasis
we concluded that this novel beta-globin gene mutation was associated with the mild phenotype of beta-thal.
We first report a novel beta chain variant, Hb Heze [beta144(HC1)Lys-->Arg; HBB: c.434A>G], in a Chinese family. Heterozygous inheritance of the mutation results in a mild beta-thalassemia (beta-thal) phenotype, whereas compound heterozygosity of Hb Heze with beta(0)-thal appears as the cause of beta-thal intermedia (beta-TI) in our case.
the Fe-His bond of the beta subunits at alkaline pH causes a substantial increase in the change in global structure upon binding of CO to the beta subunit (显示 POLG 抗体)
We screened for b-thalassemia-causing mutations by direct sequencing in different districts of West Bengal. Mutation detection was done using Sanger sequencing of the HBB gene. Results: A total of 14 different mutations were observed, including rare mutations IVS1-130(G>C), IVS1-129(A>C), -90(T>C), CD16 (显示 CD16 抗体)(-C), -30(T>C), CD15 (显示 FUT4 抗体)(-T), and a novel mutation CD53 (显示 CD53 抗体)(C>T).
A report on the frequency and spectrum of beta globin gene mutations in thalassemia patients in a Pakistani population.
Data show that mediator is recruited to the beta-globin locus by the LDB1 (显示 LDB1 抗体) complex.
In hemizygous beta-globin knockout (BKO) mice, the duodenal calcium transport was lower than that in wild-type littermates, and severity was especially pronounced in female mice.
The study analyzed protein-DNA interactions in the murine beta-globin gene locus.
Data suggest that beta-globin promoters in general do not exert any appreciable nonlocal effects on chromatin structure.
HIRA (显示 HIRA 抗体) is not only critical for beta-globin expression but is also required for activation of the erythropoietic regulators EKLF (显示 KLF1 抗体) and GATA binding protein 1 (GATA1).
results revealed iron deficiency induced expression changes in two genes which have never before been implicated in an iron-dopamine pathway, Cxcl12 and hemoglobin, beta adult chain
Data indicate that Myb and BCL11A cooperate with DNMT1 to achieve developmental repression of embryonic and fetal beta-like human transgenic globin genes in the adult erythroid environment.
Dynamic changes in chromatin structure of the beta-globin locus, were examined.
GATA1 (显示 GATA1 抗体)-HS2 (显示 SPTB 抗体) enhancer allows persistent and position-independent expression of a beta (显示 SUCLA2 抗体)-globin transgene
The limiting effect on RNA levels occurs after beta-globin genes associate with transcription factories, at which time hypersensitivity sites contribute to the RNA arising from each burst of transcription by stimulating transcriptional elongation.
The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.
, hemoglobin beta chain
, hemoglobin subunit beta
, beta globin
, hemoglobin beta-1/2 chain
, hemoglobin subunit beta-1/2
, Hemoglobin beta chain
, globin, beta
, hemoglobin beta
, beta globin chain
, III beta-1 globin
, III beta-2 globin
, hemoglobin beta chain complex
, hemoglobin beta chain, major-form
, hemoglobin beta-1 chain
, hemoglobin subunit beta-1