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HMCN1 encodes a large extracellular member of the immunoglobulin superfamily. 再加上，我们可以发Hemicentin 1 试剂盒 (4) 和 和数多这个蛋白质的别的产品。
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mutant and dose-dependent interaction data suggest a potential involvement of Hmcn1 in Fraser complex-dependent basement membrane anchorage
A null-variant in HMCN1 (c.4162delC), has been identified in a Tunisian Jewish family with early-onset age-related macular degeneration.
HMCN1 mutation is associated with gastric and colorectal cancers.
Fibulin-6, a fibroblast-released extracellular matrix protein, may play an important role during myocardial remodelling by imparting an effect on cardiac fibroblasts migration in close and complementary interplay with TGF-beta1 (显示 TGFB1 抗体) signalling
The identified variants of HMCN1 are on conserved domains, particularly the two variants on calcium-binding epidermal growth factor (显示 EGF 抗体) domain.
this is the first association study based on a candidate gene approach to confirm that a HMCN1 polymorphism (rs2891230) is associated with postpartum depression diagnosis. heterozygosity (GA) for this SNP was associated with an increased risk of PPD (显示 HPD 抗体).
Constructs show that EGF (显示 EGF 抗体) repeats 4 and 5 are required for hemicentin-dependent assembly and function of transgenic fibulin-1D (显示 FBLN1 抗体) in native locations.
We mapped the ARMD1 gene. Identification of the genes involved in AMD (显示 AMD1 抗体) will lead to a better understanding of this disease at the molecular level.
None of our subjects (258 macular degeneration,AMD (显示 AMD1 抗体), cases, 72 non-AMD (显示 AMD1 抗体) controls) had the Gln5345Arg variant in the HMCN1 gene.
We were not able to demonstrate an association between the Hemicentin-1, hOgg1, and E-selectin (显示 SELE 抗体) SNPs and age-related macular degeneration development in the currently available cases and controls.
The CFH (显示 CFH 抗体) gene and Hemicentin-1 genes do not appear to be involved in a statistically significant fraction of dry AMD (显示 AMD1 抗体) (age-related macular degeneration) cases in the Japanese population.
This study showed that extracellular hemicentin-1[Hmcn1] assemble at the cleavage furrow of dividing cells in the C. elegans germline and in preimplantation mouse embryos.
This gene encodes a large extracellular member of the immunoglobulin superfamily. A similar protein in C. elegans forms long, fine tracks at specific extracellular sites that are involved in many processes such as stabilization of the germline syncytium, anchorage of mechanosensory neurons to the epidermis, and organization of hemidesmosomes in the epidermis. Mutations in this gene may be associated with age-related macular degeneration.
, hemicentin 1