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HHEX encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. 再加上，我们可以发Hematopoietically Expressed Homeobox 抗体 (128) 和 Hematopoietically Expressed Homeobox 蛋白 (9)和数多这个蛋白质的别的产品。
Data show that knockdown of hematopoietically expressed homeobox (hhex) resulted in a down-regulation of ventral pancreatic precursor 1 (vpp1 (显示 ATP6V0A1 ELISA试剂盒)) expression and a specific loss of the ventral pancreas.
A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer.
HHEX over expression induced by human cytomegalovirus infection closely associated with vascular proliferative diseases.
The multivariate logistic regression analysis with reference to both alleles and genotypes of CDKAL1 (显示 CDKAL1 ELISA试剂盒) SNPs showed significant association, suggesting an important role for this gene in the T2DM pathophysiology. INTERPRETATION & CONCLUSIONS: A significant association was seen of all the three SNPs of CDKAL1 (显示 CDKAL1 ELISA试剂盒) and CDKN2A/B genes with T2DM but none of the two SNPs of HHEX.
These studies identify uPA (显示 PRAP1 ELISA试剂盒)-dependent de-repression of vegfr1 (显示 FLT1 ELISA试剂盒) and vegfr2 (显示 KDR ELISA试剂盒) gene transcription through binding to HHEX/PRH as a novel mechanism by which uPA (显示 PRAP1 ELISA试剂盒) mediates the pro-angiogenic effects of VEGF (显示 VEGFA ELISA试剂盒) and identifies a potential new target for control of pathologic angiogenesis.
Low HHEX mutation is associated with Thyroid Dysgenesis.
Data suggest that hematopoietically expressed homeobox protein (HHEX) downmodulation by promyelocytic leukemia (显示 PML ELISA试剂盒)-retinoic acid receptor alpha (显示 RARA ELISA试剂盒) fusion oncoprotein (PML (显示 PML ELISA试剂盒)-RARalpha (显示 RARA ELISA试剂盒)) is a key event during acute promyelocytic leukemia (显示 PML ELISA试剂盒) (APL (显示 FASL ELISA试剂盒)) pathogenesis.
Hhex binds to the Cdkn2a locus and directly interacts with the Polycomb (显示 CBX2 ELISA试剂盒)-repressive complex 2 (PRC2) to enable H3K27me3-mediated epigenetic repression
Data suggest that Hhex is a novel regulator of c-Myc (显示 MYC ELISA试剂盒) function that limits c-Myc (显示 MYC ELISA试剂盒) activity in transformed cells.
PRH controls the migration of multiple epithelial cell lineages in part at least through the direct transcriptional regulation of Endoglin (显示 ENG ELISA试剂盒)
HHEX promotes hepatic specification by repressing EOMES (显示 EOMES ELISA试剂盒) expression.
Data indicate the potential importance of CDKAL1 (显示 CDKAL1 ELISA试剂盒) protein and homeobox protein HHEX in glucose homeostasis in this Alaska Native population with a low prevalence of type 2 diabetes (T2D).
The Hhex evolutionarily conserved non-coding region appears to be a core node for the convergence of the transcription factor network that governs the emergence of Hematopoietic stem cells.
Hhex(-/-) mESCs fail to differentiate from definitive endoderm to hepatic endoderm.
results implicate Hhex in the maintenance of LT-HSCs and in lineage allocation from multipotent progenitors especially in stress hematopoiesis.
Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2 (显示 LMO2 ELISA试剂盒)-transgenic mice.
Hhex is a key regulator of early lymphoid development, functioning, at least in part, via regulation of the cell cycle.
Hhex and Cer1 (显示 CER1 ELISA试剂盒) are indispensable components of the Sox17 (显示 SOX17 ELISA试剂盒) pathway for cardiopoiesis.
Hhex as the first transcriptional regulator specifically required for islet delta cells and suggest compromised paracrine control as a contributor to T2DM
Data suggest that GPC3 (显示 GPC3 ELISA试剂盒) down-regulates hepatocyte proliferation by binding to hedgehog (显示 SHH ELISA试剂盒) (HH) and down-regulating the HH signaling pathway and binding with CD81 (显示 CD81 ELISA试剂盒), thus making it unavailable to bind to Hhex and causing its nuclear translocation.
Hex expression and subcellular localization are associated with chondrocyte maturation
hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors.
Data suggest that zebrafish hhex appears to be activated by Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) in the dorsal yolk syncytial layer, where bozozok acts in a permissive way to limit repression of hhex by Vega1 and Vega2.
This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation.
Homeobox protein PRH
, hematopoietically-expressed homeobox protein hhex
, homeobox protein hex
, homeodomain transcription factor
, hematopoietically expressed homeobox
, hematopoietically-expressed homeobox protein HHEX
, homeobox protein HEX
, homeobox protein PRH
, homeobox, hematopoietically expressed
, proline-rich homeodomain-containing transcription factor
, hematopoietically expressed homeobox protein
, hematopoietically expressed homeobox, related sequence 2
, hematopoietically-expressed homeobox protein Hhex