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HLTF encodes a member of the SWI/SNF family. 再加上，我们可以发HLTF 抗体 (79) 和 HLTF 蛋白 (5)和数多这个蛋白质的别的产品。
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A large number of SNF2 (显示 SMARCA2 ELISA试剂盒) family, DNA and ATP-dependent motor proteins are needed during transcription, DNA replication, and DNA repair to manipulate protein-DNA interactions and change DNA structure. SMARCAL1 (显示 SMARCAL1 ELISA试剂盒), ZRANB3, and HLTF are three related members of this family with specialized functions that maintain genome stability during DNA replication. [review]
depletion of SMARCAL1 (显示 SMARCAL1 ELISA试剂盒), a SNF2 (显示 SMARCA2 ELISA试剂盒)-family DNA translocase that remodels stalled forks, restores replication fork stability and reduces the formation of replication stress-induced DNA breaks and chromosomal aberrations in BRCA1/2-deficient cells. In addition to SMARCAL1 (显示 SMARCAL1 ELISA试剂盒), other SNF2 (显示 SMARCA2 ELISA试剂盒)-family fork remodelers, including ZRANB3 and HLTF, cause nascent DNA degradation and genomic instability
HIV-1 vpr reprograms CRL4(DCAF1) E3 to direct HLTF for proteasome-dependent degradation independent from previously reported Vpr interactions with base excision repair enzyme uracil DNA glycosylase (UNG2 (显示 UNG ELISA试剂盒)) and crossover junction endonuclease MUS81 (显示 MUS81 ELISA试剂盒), which Vpr also directs for degradation via CRL4(DCAF1) E3.
Fasudil reduced LPS (显示 IRF6 ELISA试剂盒)-mediated TF and PAI-1 (显示 SERPINE1 ELISA试剂盒) expression and activity in PBMCs. These effects may partially be relevant to the clinical benefits of fasudil in the treatment of CAPD patients.
HLTF is degraded in lymphocytic cells and macrophages infected with Vpr-expressing HIV-1. Our results reveal a previously unidentified strategy for HIV-1 to antagonize DNA repair in host cells.
HLTF expression is altered in various cancers via two mechanisms: gene silencing through promoter hypermethylation or alternative mRNA splicing, which leads to the expression of truncated proteins that lack DNA repair domains. [review]
HLTF promotes the filling-in of gaps left opposite damaged DNA during replication, and this postreplication repair function depends on its HIRAN domain.
Findings indicate a mechanism of helicase-like transcription factor HLTF-mediated fork reversal and suggest the requirement for distinct fork remodeling activities in the cell.
Study demonstrates a correlation between HLTF expression level and thyroid neoplastic progression where three truncated forms are detected in thyroid carcinoma.
We were able to provide evidence that methylation of HLTF and especially HPP1 detected in serum is strongly correlated with cell death in CRC using LDH as surrogate marker
Prolactin (显示 PRL ELISA试剂盒) dependent Jak2 (显示 JAK2 ELISA试剂盒) phosphorylation of RUSH.
Splice arrays and RT-PCR showed that although most splice variants in RUSH and ATP11B (显示 ATP11B ELISA试剂盒) are conserved in human and rabbit, the RFBP isoform is specific to rabbit.
silencing Hltf during heart organogenesis compromised DNA double-strand break repair, and caused aberrant collagen biogenesis altering the structural network that transmits cardiomyocyte force into muscle contraction
Data show a role of helicase-like transcription factor (hltf) in the G2/m transition and apoptosis in brain
p11 (显示 S100A10 ELISA试剂盒) and AnxA2 (显示 ANXA2 ELISA试剂盒) cooperate to create a unique binding pocket, but the optimal binding condition is not achieved without conformational changes associated with target binding. Upon interaction with the SMARCA3 peptide, both Asp60 in p11 (显示 S100A10 ELISA试剂盒) and Ser12 in AnxA2 (显示 ANXA2 ELISA试剂盒) flip inward toward the peptide-binding groove, forming additional intermolecular hydrogen bonds.
Results demonstrate that loss of HLTF function promotes the malignant transformation of intestinal or colonic adenomas to carcinomas by inducing genomic instability.
This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein.
helicase-like transcription factor
, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a3
, DNA-binding protein/plasminogen activator inhibitor 1 regulator
, DNA-binding protein/plasminogen activator inhibitor-1 regulator
, RING finger protein 80
, SNF2-like 3
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3
, sucrose nonfermenting protein 2-like 3
, sucrose nonfermenting-like 3
, RUSH 1
, TNF-response element-binding protein
, helicase-like transcription factor-like protein