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HERC3 encodes a member the HERC ubiquitin ligase family. 再加上，我们可以发和数多这个蛋白质的别的产品。
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HERC3 negatively regulates NF-kappaB (显示 NFKB1 抗体) signaling by enhancing RelA (显示 NFkBP65 抗体) subunit degradation.
we found somatic mutations of HERC2 (显示 HERC2 抗体), HERC3, TRIP12 (显示 TRIP12 抗体), UBE2Q1 (显示 UBE2Q1 抗体) and UBE4B (显示 UBE4B 抗体) genes in gastric carcinoma and colorectal carcinomas with microsatellite instability
Allele-specific polyadenylation occurs at the imprinted Herc3/Nap1l5 locus.
This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
probable E3 ubiquitin-protein ligase HERC3
, hect domain and RLD 3
, Putative E3 ubiquitin-protein ligase HERC3
, probable E3 ubiquitin-protein ligase HERC3-like
, HECT domain and RCC1-like domain-containing protein 3