HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) ELISA试剂盒

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. 再加上,我们可以发HACE1 抗体 (27)HACE1 蛋白 (4)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
HACE1 57531 Q8IYU2
HACE1 209462 Q3U0D9
HACE1 361866 D3ZBM7

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适于 HACE1 相互作用对的更多 ELISA 试剂盒

Human HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) interaction partners

  1. Mechanistic studies showed that HACE1 exerts its inhibitory role on virus-induced signaling by disrupting the MAVS (显示 MAVS ELISA试剂盒)-TRAF3 (显示 TRAF3 ELISA试剂盒) complex.

  2. HACE1 can act as a haploinsufficient tumor suppressor gene in most B-cell lymphomas and can be downregulated by deacetylation of its promoter region chromatin

  3. Hepatocellular carcinoma patients with low HACE1 expression levels exhibited poorer overall survival and HACE1 was found to be an independent prognostic factor for survival.

  4. HACE1 as a specific E3 ligase that polyubiquitinates YB-1 through non-canonical K27 linked ubiquitin chains.

  5. Biallelic loss-of-function mutations in HACE1 are associated with an autosomal recessive neurodevelopmental syndrome.

  6. supports a critical role for HACE1 in breast cancer progression and identifies patients that may benefit from Rac (显示 AKT1 ELISA试剂盒)-targeted therapies

  7. contrary to previous report, overexpression of HACE1 by transduction of recombinant protein did not affect proliferation or survival of NKTCL cell lines. We therefore conclude that HACE1 is not directly involved in NKTCL pathophysiology

  8. HACE1-OPTN (显示 OPTN ELISA试剂盒) axis synergistically suppresses growth and tumorigenicity of lung cancer cells.

  9. Ubiquitylation and activation of RAB11a (显示 RAB11A ELISA试剂盒) is promoted by a beta2 adrenergic receptor (显示 ADRB2 ELISA试剂盒)-HACE1 complex.

  10. HACE1 reduces oxidative stress and mutant Huntingtin (显示 HTT ELISA试剂盒) toxicity by promoting the NRF2 (显示 GABPA ELISA试剂盒) response.

Mouse (Murine) HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) interaction partners

  1. HACE1 controls TNF (显示 TNF ELISA试剂盒)-elicited cell fate decisions and exerts tumor suppressor and anti-inflammatory activities via a TNFR1 (显示 TNFRSF1A ELISA试剂盒)-RIP3 (显示 MPRIP ELISA试剂盒) kinase-necroptosis pathway.

  2. Increased reactive oxygen species (ROS (显示 ROS1 ELISA试剂盒)) production due to Hace1 loss leads to glutamine (显示 GFPT1 ELISA试剂盒) addiction as a mechanism to cope with increased ROS (显示 ROS1 ELISA试剂盒)-induced oxidative stress.

  3. Data indicate that HECT E3 ubiquitin ligase HACE1 deficiency accelerates pressure overload-induced heart failure.

  4. HACE1-OPTN (显示 OPTN ELISA试剂盒) axis synergistically suppresses growth and tumorigenicity of lung cancer cells.

  5. Hace1 controls ROS (显示 ROS1 ELISA试剂盒) generation of vertebrate Rac1-dependent NADPH oxidase (显示 NOX1 ELISA试剂盒) complexes.

HACE1 抗原简介

Antigen Summary

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB (By similarity).

Gene names and symbols associated with HACE1

  • HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (HACE1) 抗体
  • HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 (HACE1) 抗体
  • HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (hace1) 抗体
  • HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 (LOC100342048) 抗体
  • HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 (hace1) 抗体
  • HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 (Hace1) 抗体
  • 1700042J16Rik 抗体
  • A730034A22Rik 抗体
  • BC025474 抗体
  • HACE1 抗体

Protein level used designations for HACE1

HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 , E3 ubiquitin-protein ligase HACE1 , HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1 , E3 ubiquitin-protein ligase HACE1-like , e3 ubiquitin-protein ligase HACE1-like

GENE ID SPECIES
100071887 Equus caballus
462900 Pan troglodytes
734146 Xenopus (Silurana) tropicalis
100342048 Oryctolagus cuniculus
100399774 Callithrix jacchus
100438368 Pongo abelii
100475389 Ailuropoda melanoleuca
100548893 Meleagris gallopavo
100562508 Anolis carolinensis
100581995 Nomascus leucogenys
446912 Xenopus laevis
421788 Gallus gallus
57531 Homo sapiens
475010 Canis lupus familiaris
100156102 Sus scrofa
527565 Bos taurus
209462 Mus musculus
361866 Rattus norvegicus
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