anti-HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) 抗体

HUWE1 encodes a member of the HECT E3 ubiquitin ligase family. 再加上,我们可以发HUWE1 试剂盒 (25)HUWE1 蛋白 (2)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
HUWE1 10075 Q7Z6Z7
HUWE1 59026 Q7TMY8
HUWE1 501546  

antibodies-online.cn销售最多的anti-HUWE1 抗体

Showing 10 out of 69 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 ICC, IF, IHC, IHC (p), IP, PLA, WB Detection of Human Ureb1/Lasu1 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 mcg for WB, 1 mg for IP, 1/4 of IP loaded) from 293T cells. Antibodies: ABIN152075 used at 1 mcg/ml for WB (A and B) and at 3 mcg/mg lysate for IP (B). Ureb1/Lasu1 was less efficiently immunoprecipitated by another Ureb1/Lasu1 antibody, which is an affinity purified rabbit antibody to a downstream epitope from Ureb1/Lasu1. Detection: Chemiluminescence with an exposure time of 10 seconds. Immunohistochemistry-Paraffin: HUWE1 Antibody [ABIN152075] - FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit antiLasu1/Ureb1 used at a dilution of 1:1,000 (1ug/ml). Detection: DAB Counterstain: IHC Hematoxylin (blue). 100 μL Log in to see 25至31个工作日
¥3,977.17
详细
非结合性 EIA, IF, WB   0.1 mg Log in to see 28至34个工作日
¥3,065.96
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小鼠 非结合性 ELISA, WB Western Blot detection against Immunogen (36.45 KDa) . 50 μL Log in to see 29至34个工作日
¥2,071.99
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非结合性 IHC (p), WB 50 μg Log in to see 29至35个工作日
¥5,095.23
详细
非结合性 IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with HUWE1 antibody ABIN213933 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Heart (formalin-fixed, paraffin-embedded) stained with HUWE1 antibody ABIN213933 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 29至35个工作日
¥4,324.07
详细
山羊 非结合性 ELISA   0.1 mg Log in to see 25至31个工作日
¥2,594.28
详细
非结合性 ELISA, ICC, IF, WB Immunocytochemistry/Immunofluorescence: HUWE1 Antibody [NBP1-76795] - Daudi cells with HUWE1 antibody at 5 ug/ml. Western Blot: HUWE1 Antibody [NBP1-76795] - Daudi cell lysate with HUWE1 antibody at 1 ug/ml. 0.1 mg Log in to see 26至33个工作日
¥3,655.56
详细
非结合性 ICC, ELISA, WB   100 μg Log in to see 33至41个工作日
¥4,502.45
详细
Alexa Fluor 350 IF (p)   100 μL Log in to see 14至17个工作日
¥3,555.98
详细
Alexa Fluor 488 IF (p)   100 μL Log in to see 14至17个工作日
¥3,555.98
详细

通过反应活性、应用领域、克隆类型和共轭标记 HUWE1 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-HUWE1 抗体

  1. Human Polyclonal HUWE1 Primary Antibody for ICC, IF - ABIN152075 : Hall, Kow, Nevis, Lu, Luce, Zhong, Cook: Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage. in Molecular biology of the cell 2007 (PubMed)
    Show all 14 references for 152075

  2. Human Polyclonal HUWE1 Primary Antibody for ICC, ELISA - ABIN1001821 : Gallagher, Kefford, Rizos: The ARF tumour suppressor. in The international journal of biochemistry & cell biology 2006 (PubMed)
    Show all 4 references for 1001821

  3. Human Polyclonal HUWE1 Primary Antibody for ELISA - ABIN4222056 : Stankiewicz, Livingstone, Mohseni, Mosser: Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70. in Cell death and differentiation 2009 (PubMed)

  4. Human Polyclonal HUWE1 Primary Antibody for ELISA, WB - ABIN564354 : Katsogiannou, Andrieu, Baylot, Baudot, Dusetti, Gayet, Finetti, Garrido, Birnbaum, Bertucci, Brun, Rocchi: The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. in Molecular & cellular proteomics : MCP 2014 (PubMed)

更多抗HUWE1的相互作用对抗体

Human HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) interaction partners

  1. HUWE1 is essential for genomic stability, by promoting replication of damaged DNA We show that HUWE1-knockout cells are unable to mitigate replication stress, resulting in replication defects and DNA breakage.

  2. N-myc expression was upregulated in response to stress or following loss of Huwe1, which led to increased proliferation and stem-cell exhaustion.

  3. The interaction with Huwe1 and polyubiquitylation were blocked by disruption of casein kinase 1 (CK1 (显示 CSNK1A1 抗体)) activity, and mass spectrometry and mutational analysis identified serine 334 as an important phosphorylation site for Atoh1 (显示 ATOH1 抗体) ubiquitylation and subsequent degradation.

  4. Elevated HECTH9 protein expression is associated with pathogenesis of hepatocellular carcinoma.

  5. Mechanistic investigation revealed that HUWE1 can regulate p53 protein level through its stabilization. HUWE1 functions as a tumour suppressor in thyroid cancer progression, which may represent a novel therapeutic target for prevention or intervention of thyroid cancer.

  6. We identified a HUWE1 mutation in an affected male with Juberg-Marsidi and Brooks syndromes from the original family reported by Juberg and Marsidi; it is evident the syndrome does not result from a mutation in ATRX as reported in the literature. Additionally, the data indicated that Juberg-Marsidi syndrome and Brooks syndromes are allelic having the same HUWE1 mutation.

  7. Results reveal a pathway controlled by ATM, SIRT6, and SNF2H to block HUWE1, which stabilizes H2AX and induces its incorporation into chromatin only when cells are damaged.

  8. miR-542-5p plays a critical role in the proliferation of osteosarcoma and targets HUWE1.

  9. TNF (显示 TNF 抗体) activates Mule by inducing the dissociation of Mule from its inhibitor ARF (显示 CDKN2A 抗体). Inhibition of Mule phosphorylation by silencing Syk (显示 SYK 抗体) prevents this, thereby inhibiting Mule E3 ligase activity and TNF (显示 TNF 抗体)-induced JNK (显示 MAPK8 抗体) activation and cell death.

  10. HUWE1 and NEDD4-1 (显示 NEDD4 抗体) are two E3 ligases that are fundamental enzymes in the post-translational regulation of ABCG1 (显示 ABCG1 抗体) and ABCG4 (显示 ABCG4 抗体) protein levels and cellular cholesterol export activity

Mouse (Murine) HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) interaction partners

  1. Taken together, these data identify HUWE1 as a bona fide tumour suppressor gene in the intestinal epithelium and suggest a potential vulnerability of HUWE1-mutated tumours to DNA-damaging agents and inhibitors of anti-apoptotic proteins.

  2. Mule also regulates protein levels of the receptor tyrosine kinase (显示 ERBB3 抗体) EphB3 (显示 EPHB3 抗体) by targeting it for proteasomal and lysosomal degradation.

  3. this study shows that the E3-ubiquitin ligase Huwe1 (HECT, UBA, and WWE domain-containing 1) is required for proliferating stem cells of the adult mouse hippocampus to return to quiescence.

  4. TNF (显示 TNF 抗体) activates Mule by inducing the dissociation of Mule from its inhibitor ARF (显示 CDKN2A 抗体). Inhibition of Mule phosphorylation by silencing Syk (显示 SYK 抗体) prevents this, thereby inhibiting Mule E3 ligase activity and TNF (显示 TNF 抗体)-induced JNK (显示 MAPK8 抗体) activation and cell death.

  5. expression level of miR (显示 MLXIP 抗体)-98, which can regulate Caspase-3 (显示 CASP3 抗体), was significantly decreased. Huwe1, the host gene of miR (显示 MLXIP 抗体)-98, was positively associated with miR (显示 MLXIP 抗体)-98 expression after Silica NP exposure

  6. Thus, modulating the levels of both Huwe1 and USP10 (显示 USP10 抗体) appears to fine-tune the requisite degradation of TBP (显示 TBP 抗体) during myogenesis.

  7. Results show that ARF-BP1 was expressed at high levels in B-cell lymphoma cell lines and by regulating MYC and p53 transcriptional activity, ARF-BP1 is a critical determinant of the proliferation of B cell lymphomas.

  8. The dynamic balance between MYC and p53 required for normal B cell maturation and function is finely tuned and critically dependent on the activities of ARF-BP1.

  9. data demonstrate in vivo that Mule suppresses Ras-mediated tumorigenesis by preventing an accumulation of c-Myc (显示 MYC 抗体)/Miz1 (显示 PIAS2 抗体) complexes that mediates p21 (显示 D4S234E 抗体) and p15 (显示 CDKN2B 抗体) down-regulation

  10. an important role of ARF-BP1 in maintaining beta-cell homeostasis in aging mice and reveal that the stability of p53 is critically regulated by ARF-BP1 in vivo.

Cow (Bovine) HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) interaction partners

  1. E3Histone is therefore a HECT domain E3 that likely plays an important role in the chromatin condensation

HUWE1 抗原简介

蛋白简介

This gene encodes a member of the HECT E3 ubiquitin ligase family. The HECT domain lies in the C-terminus and contains the active-site cysteine which forms an intermediate ubiquitin-thioester bond. E3 family members are divided into three subfamilies based on their protein-protein interaction domains\; this gene encodes a member of the SI(ngle)-HECT E3 subfamily. In lung, breast, and colorectal carcinomas, this gene is highly expressed. Mutations in this gene has been found in 3 unrelated families with X-linked syndromic mental retardation, Turner type.

Gene names and symbols associated with HUWE1

  • HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1) 抗体
  • HECT, UBA and WWE domain containing 1 (Huwe1) 抗体
  • HECT, UBA and WWE domain containing 1 (HUWE1) 抗体
  • HECT, UBA and WWE domain containing 1 (huwe1) 抗体
  • HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (Huwe1) 抗体
  • 5430439H10Rik 抗体
  • arf-bp1 抗体
  • AU041296 抗体
  • C80292 抗体
  • C430014N20Rik 抗体
  • Gm1718 抗体
  • hecth9 抗体
  • hspc272 抗体
  • Huwe1 抗体
  • ib772 抗体
  • lasu1 抗体
  • mule 抗体
  • si:dkey-242a8.2 抗体
  • URE-B1 抗体
  • ureb1 抗体

Protein level used designations for HUWE1

ARF-binding protein 1 , BJ-HCC-24 tumor antigen , E3 ubiquitin-protein ligase HUWE1 , HECT domain protein LASU1 , Mcl-1 ubiquitin ligase E3 , URE-binding protein 1 , homologous to E6AP carboxyl terminus homologous protein 9 , large structure of UREB1 , upstream regulatory element-binding protein 1 , E3Histone , HECT, UBA and WWE domain-containing protein 1 , Mcl-1 ubiquitin ligase , URE-B1 , upstream regulatory element binding protein 1 , HECT, UBA and WWE domain containing 1 , rp3-339a18.4 , e3 ubiquitin-protein ligase HUWE1-like

GENE ID SPECIES
10075 Homo sapiens
59026 Mus musculus
465650 Pan troglodytes
480931 Canis lupus familiaris
511826 Bos taurus
559439 Danio rerio
700136 Macaca mulatta
100060375 Equus caballus
100123214 Nasonia vitripennis
100126217 Xenopus (Silurana) tropicalis
100380641 Salmo salar
100483129 Ailuropoda melanoleuca
100563451 Anolis carolinensis
501546 Rattus norvegicus
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