anti-HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 2 (HECW2) 抗体

E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. 再加上,我们可以发HECW2 蛋白 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
HECW2 316395  
HECW2 57520 Q9P2P5
HECW2 329152 Q6I6G8
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Showing 10 out of 47 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 ELISA, WB Western blot analysis of extracts from LOVO/HepG2 cells, using HECW2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2至3个工作日
$302.50
详细
山羊 非结合性 ELISA, WB   100 μg Log in to see 6至7个工作日
$221.76
详细
非结合性 EIA, WB Western blot analysis of HECW2 Antibody (Center) in mouse brain tissue lysates (35ug/lane). This demonstrates the HECW2 antibody detected the HECW2 protein (arrow). 0.4 mL Log in to see 6至8个工作日
$390.50
详细
非结合性 ELISA, WB 100 μL Log in to see 16 Days
$175.80
详细
非结合性 WB HECW2 Antibody (Center)  western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the HECW2 antibody detected the HECW2 protein (arrow). 400 μL Log in to see 10至11个工作日
$324.50
详细
小鼠 非结合性 ELISA, WB Detection limit for recombinant GST tagged HECW2 is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8至11个工作日
$450.00
详细
非结合性 IC, IF, WB Immunofluorescent analysis of HECW2 staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Western blot analysis of HECW2 expression in A549 (A), NIH3T3 (B) whole cell lysates. 200 μL Log in to see 13至14个工作日
$487.50
详细
小鸡 山羊 非结合性 ELISA   100 μg Log in to see 7至9个工作日
$507.83
详细
非结合性 IHC, IHC (p) Immunohistochemistry: NEDL2 Antibody [NBP1-92174] - Staining of human lung shows strong cytoplasmic positivity in subsets of alveolar cells. Immunocytochemistry/Immunofluorescence: NEDL2 Antibody  - Staining of human cell line A-431 shows localization to endoplasmic reticulum. 0.1 mL Log in to see 10至13个工作日
$439.69
详细
小鼠 非结合性 ELISA, WB Detection limit for recombinant GST tagged HECW2 is approximately 0.3ng/ml as a capture antibody. Western Blot detection against Immunogen (37.73 KDa) . 100 μg Log in to see 11至12个工作日
$430.00
详细

通过反应活性、应用领域、克隆类型和共轭标记 HECW2 抗体

特性 应用范围 宿主 克隆类型 标记
Rat (Rattus) ,


Human , ,
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Mouse (Murine) ,
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更多抗HECW2的相互作用对抗体

Human HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 2 (HECW2) interaction partners

  1. HECW2, a novel EC ubiquitin E3 ligase, plays a critical role in stabilizing endothelial cell-to-cell junctions by regulating AMOT (显示 AMOT 抗体)-like 1 (AMOTL1 (显示 AMOTL1 抗体)) stability.

  2. HECW2 is an ubiquitin ligase that stabilises p73 (显示 TP73 抗体), a crucial mediator of neurodevelopment and neurogenesis. This study implicates pathogenic genetic variants in HECW2 as potential causes of neurodevelopmental disorders in humans.

  3. This work lends further support to previously identified candidate gene HECW2 as a novel candidate gene in intellectual disability and epilepsy. In 39 patient-parent trios, 29 de novo mutations in coding sequence were identified.

  4. Low HECW2 expression is associated with cervical cancer.

  5. NEDL2 is a novel substrate of APC (显示 APC 抗体)/C-Cdh1 (显示 CDH1 抗体) as cells exit mitosis and functions as a regulator of the metaphase to anaphase transition

Mouse (Murine) HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 2 (HECW2) interaction partners

  1. NEDL2 positively regulates enteric neural precursor proliferation through the GDNF/Akt (显示 AKT1 抗体) signaling pathway.

  2. Grk2 (显示 ADRBK1 抗体) phosphorylates the C terminus of the Na-channel beta subunit (显示 POLG 抗体) and renders the channels insensitive to inhibition by Nedd4-2 (显示 NEDD4L 抗体)

HECW2 抗原简介

蛋白简介

E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (By similarity).

Gene names and symbols associated with HECW2

  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (Hecw2) 抗体
  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (HECW2) 抗体
  • E3 ubiquitin-protein ligase HECW2 (LOC531691) 抗体
  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2b (hecw2b) 抗体
  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (hecw2) 抗体
  • A730039N16Rik 抗体
  • D030049F17Rik 抗体
  • Gm971 抗体
  • HECW2 抗体
  • mKIAA1301 抗体
  • Nedl2 抗体

Protein level used designations for HECW2

E3 ubiquitin-protein ligase HECW2 , HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 , E3 ubiquitin-protein ligase HECW2-like , e3 ubiquitin-protein ligase HECW2-like , HECT, C2 and WW domain-containing protein 2 , NEDD4-like E3 ubiquitin-protein ligase 2 , NEDD4-related E3 ubiquitin ligase NEDL2

GENE ID SPECIES
316395 Rattus norvegicus
424050 Gallus gallus
459844 Pan troglodytes
531691 Bos taurus
100055015 Equus caballus
100331355 Danio rerio
100411186 Callithrix jacchus
100444189 Pongo abelii
100469664 Ailuropoda melanoleuca
100560989 Anolis carolinensis
100602550 Nomascus leucogenys
57520 Homo sapiens
329152 Mus musculus
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