anti-HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 1 (HECW1) 抗体

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. 再加上,我们可以发和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
HECW1 23072 Q76N89
小鼠 HECW1 HECW1 94253 Q8K4P8

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产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 ICC, IF, IHC, IHC (p) Immunofluorescence: HECW1 Antibody [NBP1-93645] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli & cytoplasm. Immunohistochemistry-Paraffin: HECW1 Antibody [NBP1-93645] - Immunohistochemical staining of human pancreas shows strong nuclear and cytoplasmic positivity in exocrine glandular cells and islet cells. 0.1 mL Log in to see 28至35个工作日
¥3,591.24
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非结合性 ICC, IF Immunocytochemistry/Immunofluorescence: HECW1 Antibody  - Staining of human cell line A549 shows localization to cytosol. 100 μL Log in to see 28至35个工作日
¥3,591.24
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非结合性 IHC (p)   100 μL Log in to see 29至34个工作日
¥4,116.53
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通过反应活性、应用领域、克隆类型和共轭标记 HECW1 抗体

特性 应用范围 宿主 克隆类型
Human ,


更多抗HECW1的相互作用对抗体

Human HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 1 (HECW1) interaction partners

  1. Ndel1 (显示 NDEL1 抗体) acts as a novel upstream regulator of the trichoplein-Aurora A (显示 AURKA 抗体) pathway to inhibit primary cilia assembly.

  2. Ndel1 (显示 NDEL1 抗体) regulates Dyn2 (显示 DNM2 抗体) GTPase (显示 RACGAP1 抗体) activity and impacts GluR1 (显示 GRIA1 抗体)-containing membranes distribution in a manner reminiscent of Dyn2 (显示 DNM2 抗体).

  3. These findings suggest that the human NEDL1 transgenic mice might develop Amyotrophic lateral sclerosis-like symptoms, showing signs of motor abnormalities, accompanied with significant reduction in muscle strength.

  4. These findings suggest that RNF43 (显示 RNF43 抗体) is associated with p53 (显示 TP53 抗体)-mediated apoptosis in collaboration with NEDL1 in colorectal carcinogenesis.

  5. interaction among misfolded SOD1 (显示 SOD1 抗体), NEDL1, translocon-associated protein-delta (显示 SSR4 抗体), and Dishevelled-1 (显示 DVL1 抗体) forms a ubiquitinated protein complex that is included in potentially cytotoxic protein aggregates

  6. functional interaction of NEDL1 with p53 (显示 TP53 抗体) might contribute to the induction of apoptosis in cancerous cells bearing wild-type p53 (显示 TP53 抗体).

Mouse (Murine) HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 1 (HECW1) interaction partners

  1. Ndel1 (显示 NDEL1 抗体) acts as a novel upstream regulator of the trichoplein-Aurora A (显示 AURKA 抗体) pathway to inhibit primary cilia assembly.

HECW1 抗原简介

蛋白简介

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.

Gene names and symbols associated with HECW1

  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 (HECW1) 抗体
  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 (Hecw1) 抗体
  • 9330116H24Rik 抗体
  • AV273951 抗体
  • E130207I19Rik 抗体
  • Nedl1 抗体

Protein level used designations for HECW1

E3 ubiquitin-protein ligase HECW1 , HECT type E3 ubiquitin ligase , HECT, C2 and WW domain-containing protein 1 , NEDD4-like E3 ubiquitin-protein ligase 1 , NEDD4-like ubiquitin-protein ligase 1 , mNEDL1

GENE ID SPECIES
23072 Homo sapiens
94253 Mus musculus
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