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Granulin 蛋白

(Granulin (GRN))
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008].
Granulin Protein (GRN) (AA 494-593) (GST tag) Granulin Protein (GRN) (AA 494-593) (GST tag) Granulin Protein (GRN) (AA 494-593) (GST tag) (ABIN1355792)

GRN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP

Granulin Protein (GRN) (AA 364-430) (His tag) Granulin Protein (GRN) (AA 364-430) (His tag) Granulin Protein (GRN) (AA 364-430) (His tag) (ABIN7123193)

GRN 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

Granulin Protein (GRN) (AA 289-426) (His-IF2DI Tag) Granulin Protein (GRN) (AA 289-426) (His-IF2DI Tag) Granulin Protein (GRN) (AA 289-426) (His-IF2DI Tag) (ABIN7123192)

GRN 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA

Granulin 蛋白 by Grade

Find Granulin 蛋白 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

Granulin 蛋白 by Origin

Find Granulin 蛋白 for a variety of species such as anti-Human Granulin, anti-Mouse Granulin, anti-Rat Granulin. The species listed below are among those available. Click on a link to go to the corresponding products.

Granulin 蛋白 by Source

Here you will find Granulin 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

Granulin 蛋白 by 蛋白类型

Here you can find Granulin 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

Granulin 蛋白 by 应用范围

Find Granulin 蛋白 validated for a specific application such as ELISA, SDS, WB, Imm. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Granulin 蛋白 by 生物活性

Find Granulin 蛋白 with a specific 生物活性. The 生物活性 listed below are among those available. Click on a link to go to the corresponding products.

Popular Granulin 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (3)
  • (1)
Cat. No. ABIN1355792
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123193
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123192
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7320292
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1355791
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3080977
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3133601
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7401248
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
Cat. No. ABIN7505668
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7406296
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
Cat. No. ABIN7520050
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7396472
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7413214
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7413208
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
Cat. No. ABIN5564454
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our Granulin 蛋白

Wang, Yang, Tian, Gao, Shen, Ren, Li, Jiang, Dong: "Tumor necrosis factor receptor 2/AKT and ERK signaling pathways contribute to the switch from fibroblasts to CAFs by progranulin in microenvironment of colorectal cancer." in: Oncotarget, Vol. 8, Issue 16, pp. 26323-26333, (2018) (PubMed).

Suárez-Calvet, Capell, Araque Caballero, Morenas-Rodríguez, Fellerer, Franzmeier, Kleinberger, Eren, Deming, Piccio, Karch, Cruchaga, Paumier, Bateman, Fagan, Morris, Levin, Danek, Jucker, Masters et al.: "CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. ..." in: EMBO molecular medicine, Vol. 10, Issue 12, (2018) (PubMed).

Chen, Chang, Deng, Xu, Nguyen, Martens, Cenik, Taylor, Hudson, Chung, Yu, Yu, Herz, Farese, Kukar, Tansey: "Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 21, pp. 9202-13, (2013) (PubMed).

De Muynck, Herdewyn, Beel, Scheveneels, Van Den Bosch, Robberecht, Van Damme: "The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding." in: Neurobiology of aging, Vol. 34, Issue 11, pp. 2541-7, (2013) (PubMed).

Kim, Shin, Youn, Namkoong, Gil, Kang, Yu, Kim: "Involvement of progranulin in hypothalamic glucose sensing and feeding regulation." in: Endocrinology, Vol. 152, Issue 12, pp. 4672-82, (2011) (PubMed).

Van Damme, Van Hoecke, Lambrechts, Vanacker, Bogaert, van Swieten, Carmeliet, Van Den Bosch, Robberecht: "Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival." in: The Journal of cell biology, Vol. 181, Issue 1, pp. 37-41, (2008) (PubMed).

Aliases for Granulin 蛋白

granulin precursor (GRN) 蛋白
granulin a (grna) 蛋白
Granulins (grn) 蛋白
granulin L homeolog (grn.L) 蛋白
granulin (granulin) 蛋白
granulin (ORF1 granulin) 蛋白
granulin precursor (Grn) 蛋白
granulin (Grn) 蛋白
acrogranin 蛋白
CLN11 蛋白
DKFZp459H066 蛋白
epithelin 蛋白
GEP 蛋白
GP88 蛋白
GRN 蛋白
grn 蛋白
MGC53354 蛋白
PCDGF 蛋白
PEPI 蛋白
PGRN 蛋白
wu:fb11g12 蛋白
wu:fj18f05 蛋白
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