Granulin 抗体
(Granulin (GRN))
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008].
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Granulin 抗体 by Grade
Find Granulin 抗体 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.
Granulin 抗体 by 适用
Find Granulin 抗体 for a variety of species such as anti-Human Granulin, anti-Mouse Granulin, anti-Rat Granulin. The species listed below are among those available. Click on a link to go to the corresponding products.
Granulin 抗体 by 应用范围
Find Granulin 抗体 validated for a specific application such as WB, ELISA, IHC, IF (cc). Some of the available applications are listed below. Click on a link to go to the corresponding products.
Granulin 抗体 by 抗体来源
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Granulin 抗体 by 克隆形成能力
Find available monoclonal or polyclonal Granulin 抗体. Click on a link to go to the corresponding products.
Granulin 抗体 by 克隆
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Popular Granulin 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7440077
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7440863
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (4)
Cat. No.
ABIN7267505
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ICC, IF, IHC (p)
Validations
- (4)
Cat. No.
ABIN2854868
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (1)
- (2)
Cat. No.
ABIN728668
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
ABIN7440866
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (2)
Cat. No.
ABIN561132
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (3)
Cat. No.
ABIN516191
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (2)
Cat. No.
ABIN7434971
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC, ELISA
Validations
- (2)
Cat. No.
ABIN7154393
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (2)
Cat. No.
ABIN516190
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (2)
Cat. No.
ABIN516189
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IF
Validations
- (2)
Cat. No.
ABIN361185
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, IHC (p)
Validations
- (2)
Cat. No.
ABIN396952
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN1169131
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Granulin 抗体
: "Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, Issue 12, pp. E2849-E2858, (2018) (PubMed).: "Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations." in: eNeuro, Vol. 4, Issue 4, (2018) (PubMed).
: "Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness." in: Oncogene, Vol. 34, Issue 14, pp. 1853-64, (2015) (PubMed).
: "The molecular basis for development of proinflammatory autoantibodies to progranulin." in: Journal of autoimmunity, Vol. 61, pp. 17-28, (2015) (PubMed).
: "Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice." in: The Journal of clinical investigation, Vol. 121, Issue 2, pp. 784-99, (2011) (PubMed).
: "Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia." in: Human molecular genetics, Vol. 20, Issue 3, pp. 510-27, (2011) (PubMed).
: "Progranulin A-mediated MET signaling is essential for liver morphogenesis in zebrafish." in: The Journal of biological chemistry, Vol. 285, Issue 52, pp. 41001-9, (2010) (PubMed).
: "In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17." in: Neuro-degenerative diseases, Vol. 5, Issue 3-4, pp. 215-7, (2008) (PubMed).
: "Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma." in: Hepatology (Baltimore, Md.), Vol. 47, Issue 5, pp. 1524-32, (2008) (PubMed).
: "Stimulation of PC cell-derived growth factor (epithelin/granulin precursor) expression by estradiol in human breast cancer cells." in: Biochemical and biophysical research communications, Vol. 256, Issue 1, pp. 204-7, (1999) (PubMed).
Aliases for Granulin 抗体
granulin precursor (GRN) 抗体granulin a (grna) 抗体
Granulins (grn) 抗体
granulin L homeolog (grn.L) 抗体
granulin (granulin) 抗体
granulin (ORF1 granulin) 抗体
granulin precursor (Grn) 抗体
granulin (Grn) 抗体
acrogranin 抗体
CLN11 抗体
DKFZp459H066 抗体
epithelin 抗体
GEP 抗体
GP88 抗体
GRN 抗体
grn 抗体
MGC53354 抗体
PCDGF 抗体
PEPI 抗体
PGRN 抗体
wu:fb11g12 抗体
wu:fj18f05 抗体
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