anti-Galactosidase, alpha (GLA) 抗体

GLA encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. 再加上,我们可以发GLA 试剂盒 (37)GLA 蛋白 (18)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
GLA 2717 P06280
GLA 11605  
GLA 363494  
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Showing 10 out of 129 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB <b>WB Suggested Anti-GLA Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>Human brain 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 EIA, WB GLA Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded human Lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GLA Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Western blot analysis of GLA antibody (N-term) in Hela cell line lysates (35 µg/lane). GLA (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6至8个工作日
$390.50
详细
小鼠 非结合性 WB   100 μg Log in to see 4至6个工作日
$240.00
详细
非结合性 IP, IHC (p), WB WB Image Galactosidase alpha antibody [N1C2] detects Galactosidase alpha protein by western blot analysis. Rat tissue extracts (50 μg) was separated by 10% SDS-PAGE, and the membrane was blotted with Galactosidase alpha antibody [N1C2] , diluted at 1:1000. WB Image Galactosidase alpha antibody detects Galactosidase alpha protein by western blot analysis. Whole cell extracts (30 μg) was separated by 10% SDS-PAGE, and the membrane was blotted with Galactosidase alpha antibody , at a dilution of 1:1000. 100 μL Log in to see 1至2个工作日
$358.60
详细
Bat 非结合性 WB 50 μg Log in to see 7至9个工作日
$551.83
详细
非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human rectal carcinoma labeled with Anti-Galactosidase alpha Polyclonal Antibody, Unconjugated (ABIN872875) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Lane 1: mouse liver lysates Lane 2: human colon carcinoma lysates probed with Anti Galactosidase alpha Polyclonal Antibody, Unconjugated (ABIN872875) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 44kD. Observed band size: 44kD. 100 μL Log in to see 3至7个工作日
$295.90
详细
非结合性 FACS, IF, IHC (p), WB Western blot analysis of GLA antibody (N-term) (ABIN390687) in Hela cell line lysates (35 µg/lane). GLA (arrow) was detected using the purified polyclonal antibody. GLA Antibody (N-term) (ABIN390687) IHC analysis in formalin fixed and paraffin embedded human Lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10至11个工作日
$324.50
详细
非结合性 IHC, IHC (p) Immunohistochemistry-Paraffin: Galactosidase alpha Antibody [NBP1-89796] - Staining of human small intestine shows strong cytoplasmic positivity in glandular cells. Western Blot: alpha-Galactosidase A/GLA Antibody [NBP1-89796] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11 Lane 2: Human cell line RT-4 Lane 3: Human cell line U-251MG sp Lane 4: Human plasma (IgG/HSA depleted) Lane 5: Human liver tissue 0.1 mL Log in to see 10至13个工作日
$439.69
详细
FITC IF (p)   100 μL Log in to see 14至21个工作日
$405.90
详细
Cy3 IF (p)   100 μL Log in to see 14至21个工作日
$405.90
详细

通过反应活性、应用领域、克隆类型和共轭标记 GLA 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-GLA 抗体

  1. Human Polyclonal GLA Primary Antibody for IHC, IHC (p) - ABIN4280010 : Xu, Lun, Brignol, Hamler, Schilling, Frascella, Sullivan, Boyd, Chang, Soska, Garcia, Feng, Yasukawa, Shardlow, Churchill, Ketkar, Robertson, Miyamoto, Mihara, Benjamin, Lockhart, Hirato, Fowles et al.: Coformulation of a Novel Human α-Galactosidase A With the Pharmacological Chaperone AT1001 Leads to Improved Substrate Reduction in Fabry Mice. ... in Molecular therapy : the journal of the American Society of Gene Therapy 2015 (PubMed)

更多抗GLA的相互作用对抗体

Human Galactosidase, alpha (GLA) interaction partners

  1. alpha-galactosidase A mutation, IVS4-type Fabry disease has features similar to those of classic Fabry disease and a higher frequency of deep white matter hyperintensities and a higher incidence of infarctions and pulvinar signs than in healthy controls

  2. We demonstrate that the wild-type sequence harbors an hnRNP A1 (显示 HNRNPA1 抗体) and hnRNP A2/B1 (显示 HNRNPA2B1 抗体)-binding exonic splicing silencer (ESS) overlapping the 5'splice site (5'ss) that prevents pseudoexon inclusion.we demonstrate that splice switching oligonucleotide (SSO) mediated blocking of the pseudoexon 3'ss and 5'ss effectively restores normal GLA (显示 NAT8 抗体) splicing

  3. Four patients had non-amenable mutant forms of a-Gal (显示 GAL 抗体) based on the validated cell-based assay conducted after treatment initiation and were excluded from primary efficacy analyses only.

  4. Mesenchymal stem cells with reduced GLA (显示 NAT8 抗体) activity are prone to apoptosis and senescence due to impaired autophagy and DNA repair capacity.

  5. we review the various types of GLA (显示 NAT8 抗体) variants and recommend that pathogenicity be considered only when associated with elevated globotriaosylceramide in disease-relevant organs and tissues as analyzed by mass spectrometry.

  6. findings revealed the alternative splicing mechanism of GLA (显示 NAT8 抗体) (IVS4+919G>A), and a potential treatment for this specific genetic type of Fabry disease by amiloride in the future

  7. Results found a novel heterozygous stop codon mutation in exon 1 of the GLA (显示 NAT8 抗体) gene in female patients with Fabry Disease with methylation in the non-mutated allele thought to be associated with the clinical severity of the disease.

  8. Study described the demographic data, wide clinical spectrum of phenotypes, and GLA (显示 NAT8 抗体) mutation spectrum of Fabry disease in Korea. Most of the patients had classical Fabry disease, with a 4 times higher incidence than that of late-onset Fabry disease, indicating an underdiagnosis of mild, late-onset Fabry disease.

  9. we reviewed other small molecules that were reported to have a stabilizing effect on some GLA (显示 NAT8 抗体) missense mutations in vitro and might be developed to act in synergy or as an alternative to 1-deoxygalactonojirimycin

  10. No pathogenic mutations in the coding regions of the GLA (显示 NAT8 抗体) gene were identified in this group of patients and thus no Fabry disease was found in this study.

Mouse (Murine) Galactosidase, alpha (GLA) interaction partners

  1. the GM130 (显示 GOLGA2 抗体)-deficient mouse provides a valuable model for investigating the etiology of human globozoospermia.

  2. Mice with alpha-galactosidase A deficiency show age-dependent and distinct deficits of the sensory system.

  3. In oocyte meiosis, GM130 (显示 GOLGA2 抗体) localization and expression patterns are regulated by FMNL1 (显示 FMNL1 抗体).

  4. The histological changes in Gla KO mice better resemble the type 2 later-onset phenotype observed in patients with residual alpha-galactosidase A activity.

  5. our findings imply that the alpha-GalA KO mouse is a good model in which to study the peripheral small fiber neuropathy exhibited by FD patients

  6. we demonstrate an age-dependent microvasculopathy of the mesenteric artery in a murine model of Fabry disease (galactosidase A-knockout mice) resulting from dysregulation of the vascular homeostatic enzyme endothelial nitric oxide synthase (eNOS (显示 NOS3 抗体))

  7. GM130 (显示 GOLGA2 抗体) regulates microtubule organization and might cooperate with the MAPK (显示 MAPK1 抗体) pathway to play roles in spindle organization, migration and asymmetric division during mouse oocyte maturation

  8. It suggested that there could be a combination of GLA deficiency and FVL (显示 F5 抗体) or other thrombosis-related gene defect in patients with genetic severe early-onset thrombosis.

  9. present Toll (显示 TLR4 抗体)-like receptor-dependent negative regulation of alpha-Gal-A as a mechanistic link between pathogen recognition and self lipid antigen induction for natural killer T cells

  10. Developed a novel recombinant lentiviral vector that engineers expression of alpha-galactosidase. Analysis of tissues at 26 wks demonstrated similar alpha-gal A enzyme activities but enhanced Gb3 reduction in hearts and kidneys compared with control.

GLA 抗原简介

蛋白简介

This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.

Gene names and symbols associated with anti-Galactosidase, alpha (GLA) 抗体

  • galactosidase alpha (GLA) 抗体
  • galactosidase, alpha (Gla) 抗体
  • galactosidase, alpha (gla) 抗体
  • galactosidase alpha S homeolog (gla.S) 抗体
  • galactosidase alpha (gla) 抗体
  • alpha-galactosidase (agaN) 抗体
  • aga (aga) 抗体
  • alpha-galactosidase (agaL) 抗体
  • alpha-galactosidase (SCO0541) 抗体
  • alpha-galactosidase (rafA) 抗体
  • alpha-galactosidase (melA) 抗体
  • alpha-galactosidase (galA) 抗体
  • alpha-galactosidase A (ANI_1_2528074) 抗体
  • alpha-galactosidase A (ANI_1_1502124) 抗体
  • alpha-galactosidase A (AOR_1_390174) 抗体
  • alpha-galactosidase A (CpipJ_CPIJ002066) 抗体
  • alpha-galactosidase (aga) 抗体
  • alpha-galactosidase A (MCYG_00962) 抗体
  • alpha-galactosidase A (MCYG_00791) 抗体
  • alpha-galactosidase (gla) 抗体
  • alpha-galactosidase A (Tsp_02909) 抗体
  • alpha-galactosidase A (Tsp_02508) 抗体
  • golgi autoantigen, golgin subfamily a, 2 (Golga2) 抗体
  • galactosidase alpha (Gla) 抗体
  • galactosidase, alpha (GLA) 抗体
  • Ags 抗体
  • alpha-GAL 抗体
  • AO090005000217 抗体
  • AW555139 抗体
  • GALA 抗体
  • GM130 抗体
  • MGC130872 抗体
  • mKIAA4150 抗体
  • SCF11.21 抗体
  • SMU.877 抗体
  • zgc:101584 抗体

Protein level used designations for anti-Galactosidase, alpha (GLA) 抗体

agalsidase alfa , alpha-D-galactosidase A , alpha-D-galactoside galactohydrolase 1 , alpha-gal A , alpha-galactosidase A , melibiase , alpha-D-galactoside galactohydrolase , Alpha-galactosidase A , galactosidase, alpha , alpha-galactosidase A-like , alpha-galactosidase , Alpha-galactosidase , 130 kDa cis-Golgi matrix protein , Golgin subfamily A member 2 , SY11 protein , golgin-95

GENE ID SPECIES
2717 Homo sapiens
11605 Mus musculus
363494 Rattus norvegicus
422188 Gallus gallus
450083 Danio rerio
465761 Pan troglodytes
480988 Canis lupus familiaris
532742 Bos taurus
703129 Macaca mulatta
734749 Xenopus laevis
100022779 Monodelphis domestica
100060370 Equus caballus
100145767 Xenopus (Silurana) tropicalis
100344610 Oryctolagus cuniculus
100409841 Callithrix jacchus
100480888 Ailuropoda melanoleuca
100595113 Nomascus leucogenys
988766 Clostridium perfringens str. 13
1021683 Bifidobacterium longum NCC2705
1028243 Streptococcus mutans UA159
1095964 Streptomyces coelicolor A3(2)
1174420 Yersinia pestis CO92
1255824 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
2956399 Yersinia pseudotuberculosis IP 32953
3977399 Lactobacillus salivarius UCC118
4983447 Aspergillus niger CBS 513.88
4987403 Aspergillus niger CBS 513.88
5989256 Aspergillus oryzae RIB40
6032795 Culex quinquefasciatus
7264928 Bifidobacterium animalis subsp. lactis AD011
9223595 Arthroderma otae CBS 113480
9226616 Arthroderma otae CBS 113480
9450395 Brachyspira pilosicoli 95/1000
10899858 Trichinella spiralis
10903123 Trichinella spiralis
99412 Mus musculus
100718405 Cavia porcellus
407057 Sus scrofa
anti-GLA (GLA) 抗体 精选生产商
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