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The protein encoded by FXR1 is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. 再加上，我们可以发FXR1 抗体 (97) 和 FXR1 蛋白 (4)和数多这个蛋白质的别的产品。
FXR1P is a GSK3beta (显示 GSK3b ELISA试剂盒) substrate with a role in regulating mood and emotion processing
Removal of FXR1P from the forebrain of postnatal mice selectively enhances long-term storage of spatial memories, hippocampal late-phase long-term potentiation (L-LTP (显示 SCP2 ELISA试剂盒)), and de novo GluA2 (显示 GRIA2 ELISA试剂盒) synthesis.
FXR1P was highly expressed during hippocampal development and co-localized with ribosomes and mRNAs in the dendrite and at a subset of spines.
FXR1P is required for efficient processing of pre-microR-9 and pre-microR-124 in vitro and forms a complex with Dicer (显示 DICER1 ELISA试剂盒) and pre-miRNAs.
Fxr1 knockout hearts exhibit an up-regulation of desmoplakin (显示 DSP ELISA试剂盒) and talin2 proteins, which is accompanied by severe disruption of desmosome as well as costamere architecture and composition in the heart
Targeting the p38 mitogen-activated protein kinase (显示 MAPK14 ELISA试剂盒) pathway of LPS (显示 TLR4 ELISA试剂盒)-treated cells with small molecule inhibitors can induce FXR1 protein expression.
Four FXR1 isoforms of molecular weight 70, 74, 78, 80 kDa are widely distributed in mouse organs, while in striated (显示 NSDHL ELISA试剂盒) muscles these isoforms are replaced by proteins of 82 and 84 kDa containing an extra pocket of 27 amino acids.
FXR1P operates as a repressor of TNF (显示 TNF ELISA试剂盒) translation
the data clearly demonstrate the importance of FXR1P RBP (显示 RBP4 ELISA试剂盒) in the regulation of a wide spectrum of inflammatory genes and suggest an important role of MAP signalling in the response of macrophages to selected TLR ligands, including CpG.
Fxr1 regulates mammalian circadian behavioral rhythms.
Fxr1 plays a vital role during Xenopus embryogenesis. Knockdown of Fxr1 has highly muscle-specific (显示 EIF3K ELISA试剂盒) effects leading to disruption of MyoD (显示 MYOD1 ELISA试剂盒) expression, inhibition of somite myotomal cell rotation and segmentation, and abnormal dermatome formation.
Our findings support our a priori hypothesis of a possible interaction between GSK3B (显示 GSK3b ELISA试剂盒) (rs12630592 T allele) and FXR1 (rs496250 A allele) in mood disorder patients.
human microbiota was able to reduce the levels of tauro-beta-muricholic acid and induce expression of FXR (显示 NR1H4 ELISA试剂盒) target genes Fgf15 and Shp (显示 LAMC1 ELISA试剂盒) in ileum after long-term colonization. We show that a human microbiota can change BA composition and induce FXR (显示 NR1H4 ELISA试剂盒) signaling in colonized mice, but the levels of secondary BAs produced are lower than in mice colonized with a mouse microbiota
These data reveal a new role of FXR1 in controlling induction of monocyte migration.
FXR1 binds and destabilizes p21 (显示 CDKN1A ELISA试剂盒) mRNA, binds and stabilizes TERC RNA and suppresses the cellular senescence in oral cancer cells.
FXR1P interacts with CMAS, and that FXR1P may enhance the activation of sialic acid via interaction with CMAS, and increase GM1 levels to affect the development of the nervous system, thus providing evidence for further research into the pathogenesis of FXS.
P97 (显示 EIF4G2 ELISA试剂盒) interacts with 3' UTR (显示 UTS2R ELISA试剂盒)-binding FXR1a-associated microRNPs and with PARN (显示 PARN ELISA试剂盒), which binds mRNA 5' caps (显示 CAPS ELISA试剂盒), forming a specialized complex to translate recruited mRNAs in these altered canonical translation conditions.
An accumulation of 8 SNPs in the fragile gene family (FMR1 (显示 FMR1 ELISA试剂盒), FXR1 and FXR2 (显示 FXR2 ELISA试剂盒))were found associated with autistic traits in a sample of male patients.
The mechanisms by which FXR1 executes its regulatory function by forming a novel complex with two other oncogenes, protein kinase C (显示 PKC ELISA试剂盒), iota and epithelial cell transforming 2, located in the same amplicon via distinct binding mechanisms, were identified.
binding of PKP1 (显示 PKP1 ELISA试剂盒)/3 to FXR1 was RNA independent, and both PKP3 (显示 PKP3 ELISA试剂盒) and FXR1 stabilized PKP2 (显示 PKP2 ELISA试剂盒) mRNA.
The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.
Fragile X mental retardation syndrome-related protein 1 homolog
, fragile X mental retardation syndrome-related protein 1 homolog
, fragile X mental retardation syndrome-related protein 1
, fragile X mental retardation, autosomal homolog 1
, fragile X mental retardation-related protein 1
, fragile X mental retardation syndrome-related protein 1-like
, fragile X mental retardation gene, autosomal homolog
, fragile-X-related protein 1
, fragile X-related protein
, fragile X mental retardation syndrome-related protein 1 homolog A
, fragile X mental retardation gene 1, autosomal homolog