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FSCN1 encodes a member of the fascin family of actin-binding proteins. 再加上，我们可以发Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) 抗体 (215) 和 Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) 蛋白 (16)和数多这个蛋白质的别的产品。
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Human FSCN1 ELISA Kit for Sandwich ELISA - ABIN414808
Teng, Xu, Yue, Ma, Zhang, Zhao, Guo, Zhang, Gu, Wang: Serological investigation of the clinical significance of fascin in non-small-cell lung cancer. in Lung cancer (Amsterdam, Netherlands) 2013
Alterations in nuclear Fascin levels result in defects in nucleolar morphology in both Drosophila follicles and cultured mammalian cells, suggesting that nuclear Fascin plays an important role in nucleolar architecture.
essential for actin bundle initiation and stiffening during embryonic tracheal system development
Fascin and Ena cooperate to extend and maintain robust filopodia of uniform thickness with aligned barbed ends by a unique mechanistic cycle.
Fascin links Btl/FGFR signalling to the actin cytoskeleton during Drosophila tracheal morphogenesis.
These data lead to the conclusion that prostaglandins regulate Fascin to control actin remodeling
The terminal branchlets of different classes of neurons have distinctive dynamics and are formed on the basis of molecularly separable mechanisms; in particular, class III neurons require fascin for terminal branching whereas class IV neurons do not.
The regulatory role of FascinS52 appears to be tissuespecific, and its importance might depend on the dynamics and the turnover rate of actin bundles between various cell types.
Fascin deficiency does not impair 20-hydroxyecdysone response, but neurites fail to maintain their normal, nearly straight trajectory, instead forming curls and hooks. This is accompanied by abnormally distributed filamentous actin.
Fascin is required for plasmatocyte migration, both as these cells undergo developmental dispersal and during an inflammatory response to epithelial wounding.
study found that Rab35 (显示 RAB35 ELISA试剂盒) regulates the assembly of actin (显示 ACTB ELISA试剂盒) filaments during bristle development; effect was mediated by the a (显示 ACTB ELISA试剂盒)ctin-bundling protein fascin, which directly associated with active R (显示 RAB35 ELISA试剂盒)ab35
These data show that fscn1a-dependent filopodia are required in a subset of NC cells to promote cell migration and NC derivative formation
Filopodia formation by crosslinking of F-actin with fascin in two different binding manners
Fascin-1 expression, cadherin-17 expression, tumor size, and differentiation were independent risk factors for GC.
Fascin1 facilitates phagolysosomal fusion for killing of phagocytosed Listeria. It binds to LC3 (显示 MAP1LC3A ELISA试剂盒), an autophagosome marker, both in vivo & in vitro. It plays a critical role in dendritic cell survivalduring Listeria infection.
A tightly regulated phospho/dephospho-fascin cycle modulated by extracellular signals is required for the polarized morphology and migration in neuroblasts, thus contributing to efficient neurogenesis.
fascin 1 promotes cell migration and has a role in growth and cell cycle progression
Suppression of fascin expression results in reduction of activation-induced migration and invasion in mouse monocytic leukemia (显示 KAT6B ELISA试剂盒) RAW264.7 macrophages.
Both STAT3 (显示 STAT3 ELISA试剂盒) and NFkappaB are required for the cytokine-induced expression of fascin in cancer cells.
fascin-1 is principally expressed in neural and mesenchymal derivatives during embryonic development
We propose that fascin is a key specific actin cross-linker, providing stiffness for filopodial bundles, and that its dynamic behavior allows for efficient coordination between elongation and bundling of filopodial actin filaments.
Fascin is a novel target of beta-catenin (显示 CTNNB1 ELISA试剂盒)-TCF (显示 HNF4A ELISA试剂盒) signaling and is expressed at the invasive front of human colon cancer
MYC (显示 MYC ELISA试剂盒)-nick, fascin, and Cdc42 (显示 CDC42 ELISA试剂盒) are frequently up-regulated in cells present at the invasive front of human colorectal tumors, suggesting a coordinated role for these proteins in tumor migration.
The prognostic importance of TGF-beta (显示 TGFB1 ELISA试剂盒), TGF-beta (显示 TGFB1 ELISA试剂盒) receptor, and fascin in childhood solid tumors
The results reveal that phosphorylation at FSCN1 amino acids Y23, S38, S39 and S274, in combination, downregulates the extent of anchorage-independent growth, cell migration and filopodia formation in esophageal squamous cancer cells.
Fascin and alpha-actinin intrinsically segregate to discrete bundled domains that are specifically recognized by other actin-binding proteins.
This study showed that fascin expression intensity may be correlated with clinical outcomes of a newly diagnosed primary glioblastoma.
These data demonstrated fascin as a critical regulator of breast cancer stem cell pool at least partially via activation of the Notch (显示 NOTCH1 ELISA试剂盒) self-renewal signaling pathway.
These results suggest that strong positive fascin-1 expression can be used as a diagnostic marker of TNBC.
Authors demonstrated that one miRNA, miR (显示 MLXIP ELISA试剂盒)-29a-5p, can bind to both the XIAP (显示 XIAP ELISA试剂盒) and FSCN1 3'UTRs and play an important role in that interactions. We showed that the 3'UTR (显示 UTS2R ELISA试剂盒) of XIAP (显示 XIAP ELISA试剂盒) was able to antagonize miR (显示 MLXIP ELISA试剂盒)-29a-5p, and resulted in the increased translation of XIAP (显示 XIAP ELISA试剂盒) and FSCN1.
The expression of fascin-1 and lanminin-5 and the serum levels of fascin-1 and laminin-5 were related to the relapse of patients with non-small cell lung cancer.
The results uncover a role for fascin that operates independently of filopodia assembly to promote efficient cell migration and invasion.
FSCN1 gene plays an in prenatal skeletal muscle development and was a candidate gene for meat production trait.
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15.
, fascin 1
, singed-like protein
, 55 kDa actin-bundling protein
, singed-like (fascin homolog, sea urchin)