anti-F-Box Protein 4 (FBXO4) 抗体

FBXO4 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. 再加上,我们可以发F-Box Protein 4 试剂盒 (12)F-Box Protein 4 蛋白 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
FBXO4 26272 Q9UKT5
FBXO4 106052 Q8CHQ0
FBXO4 310363  

antibodies-online.cn销售最多的anti-F-Box Protein 4 抗体

Showing 10 out of 90 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-FBXO4 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: 293T cell lysate 100 μL Log in to see 24至29个工作日
¥3,074.65
详细
非结合性 WB Western blot analysis of FBXO4 Antibody (Center) (ABIN653243) in Y79 cell line lysates (35 µg/lane). FBXO4 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 5至8个工作日
¥2,325.14
详细
非结合性 EIA, WB Western blot analysis of FBXO4 Antibody (Center) in Y79 cell line lysates (35ug/lane). FBXO4 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 29至35个工作日
¥4,086.26
详细
非结合性 WB Whole cell extracts prepared from U2OS cells, or insect Sf9 cells expressing DYKDDDDK-FBX4, were resolved by SDS-PAGE and transferred to nitrocellulose. FBX4 was detected using anti-FBX4 at a 1:500 dilution, in TBS buffer containing 0.1% Tween-20, followed by peroxidase conjugated anti-rabbit IgG. 100 μL Log in to see 23至28个工作日
¥9,424.48
详细
Cow 非结合性 WB WB Suggested Anti-FBXO4 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: OVCAR-3 cell lysate WB Suggested Anti-FBXO4  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: OVCAR-3 cell lysate  FBXO4 is supported by BioGPS gene expression data to be expressed in OVCAR3 100 μL Log in to see 24至29个工作日
¥3,074.65
详细
山羊 非结合性 ELISA, WB   100 μg Log in to see 24至29个工作日
¥9,230.97
详细
山羊 非结合性 IHC (p), ELISA Anti-FBXO4 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN962656 concentration 41396 ug/ml. 50 μg Log in to see 29至35个工作日
¥4,324.07
详细
Bat 非结合性 WB 50 μg Log in to see 29至35个工作日
¥5,538.93
详细
非结合性 ICC, IF, WB Western Blot: FBXO4 Antibody [NBP2-21608] - Sample (30 ug of whole cell lysate) A: HL-60 10% SDS PAGE gel, diluted at 1:5000. Immunocytochemistry/Immunofluorescence: FBXO4 Antibody [NBP2-21608] - Immunofluorescence analysis of methanol-fixed HeLa, using antibody at 1:500 dilution. 0.1 mL Log in to see 26至33个工作日
¥3,655.56
详细
非结合性 ELISA, WB 50 μg Log in to see 24至29个工作日
¥4,312.06
详细

通过反应活性、应用领域、克隆类型和共轭标记 FBXO4 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-F-Box Protein 4 抗体

  1. Human Polyclonal FBXO4 Primary Antibody for EIA, WB - ABIN952288 : Zeng, Wang, Yang, Chen, Yang, Diehl, Liu, Lei: Structural basis of selective ubiquitination of TRF1 by SCFFbx4. in Developmental cell 2010 (PubMed)
    Show all 3 references for 952288

  2. Human Polyclonal FBXO4 Primary Antibody for WB - ABIN233769 : Pontano, Aggarwal, Barbash, Brown, Bassing, Diehl: Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability. in Molecular and cellular biology 2008 (PubMed)
    Show all 3 references for 233769

  3. Human Polyclonal FBXO4 Primary Antibody for WB - ABIN653243 : Barbash, Zamfirova, Lin, Chen, Yang, Nakagawa, Lu, Rustgi, Diehl: Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. in Cancer cell 2008 (PubMed)
    Show all 2 references for 653243

  4. Cow (Bovine) Polyclonal FBXO4 Primary Antibody for WB - ABIN2774698 : Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007 (PubMed)

更多抗F-Box Protein 4的相互作用对抗体

Human F-Box Protein 4 (FBXO4) interaction partners

  1. results define the impact of alternative splicing on Fbx4 function, and suggest that the attenuated cyclin D1 (显示 CCND1 抗体) degradation by these novel Fbx4 isoforms provides a new insight for aberrant cyclin D1 (显示 CCND1 抗体) expression in human cancers.

  2. The FBXO4 I377M mutant exhibits impaired cyclin D1 recruitment and ubiquitylation.

  3. 14-3-3varepsilon binds to Ser12-phosphorylated Fbx4 to mediate dimerization and function.

  4. Biochemical studies indicate that both the N-terminal domain and a loop connecting the linker and C-terminal domain of Fbx4 are critical for the dimerization and activation of the protein.

  5. results reveal an atypical small GTPase (显示 RACGAP1 抗体) domain within Fbx4 as a substrate-binding motif for SCF (显示 KITLG 抗体)(Fbx4) and uncover a mechanism for selective ubiquitination and degradation of TRF1 (显示 TERF1 抗体) in telomere homeostasis control

  6. Fbx4 is a central regulator of Pin2/TRF1 (显示 TERF1 抗体) protein abundance and alterations in the stability of Pin2/TRF1 (显示 TERF1 抗体) can have a dramatic impact on telomere length

  7. SCF (显示 KITLG 抗体)(FBX4-alphaB crystallin (显示 CRYAB 抗体)) is an E3 ubiquitin ligase (显示 MUL1 抗体) that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1 (显示 CCND1 抗体).

  8. Mutations in Fbx4 inhibit dimerization of the SCF (显示 KITLG 抗体)(Fbx4) ligase and contribute to cyclin D1 (显示 CCND1 抗体) overexpression in human cancer.

Mouse (Murine) F-Box Protein 4 (FBXO4) interaction partners

  1. Collectively, our data support a role for FBXO4 as a suppressor of esophageal tumorigenesis

  2. This study demonstrates that Fbxo4 deficiency induces Braf-driven melanoma and that this phenotype depends on cyclin D1 accumulation in mice, underscoring the importance of this ubiquitin ligase in tumor suppression.

  3. Fbx4 expression is essential for cell homeostasis in somatic cells. Fbx4 ablation predisposes mice to multiple tumor phenotypes, with concomitant cyclin D1 (显示 CCND1 抗体) deregulation and nuclear accumulation

  4. SCF (显示 KITLG 抗体)(FBX4-alphaB crystallin (显示 CRYAB 抗体)) is an E3 ubiquitin ligase (显示 MUL1 抗体) that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1 (显示 CCND1 抗体).

  5. Lysine 269 is essential for cyclin D1 (显示 CCND1 抗体) ubiquitylation by the SCF (显示 KITLG 抗体)(Fbx4/alphaB-crystallin (显示 CRYAB 抗体)) ligase.

F-Box Protein 4 (FBXO4) 抗原简介

蛋白简介

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.

Gene names and symbols associated with anti-F-Box Protein 4 (FBXO4) 抗体

  • F-box protein 4 (FBXO4) 抗体
  • F-box protein 4 (fbxo4) 抗体
  • F-box only protein 4 (fbx4) 抗体
  • F-box protein 4 (Fbxo4) 抗体
  • 1700096C12Rik 抗体
  • AI851261 抗体
  • AW494535 抗体
  • Fbx4 抗体
  • FBXO4 抗体

Protein level used designations for anti-F-Box Protein 4 (FBXO4) 抗体

F-box protein 4 , F-box only protein 4 , F-box only protein 4-like , F-box protein Fbx4

GENE ID SPECIES
431586 Gallus gallus
548694 Xenopus (Silurana) tropicalis
697007 Macaca mulatta
737372 Pan troglodytes
783766 Bos taurus
100158284 Xenopus laevis
100406305 Callithrix jacchus
100600195 Nomascus leucogenys
100194812 Salmo salar
26272 Homo sapiens
106052 Mus musculus
489220 Canis lupus familiaris
534852 Bos taurus
310363 Rattus norvegicus
101116349 Ovis aries
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