F-Box Protein 32 蛋白 (FBXO32)

FBXO32 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. 再加上,我们可以发FBXO32 抗体 (78)FBXO32 试剂盒 (30)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
FBXO32 114907 Q969P5
FBXO32 67731 Q9CPU7
FBXO32 171043 Q91Z62
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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小麦胚 GST tag 2 μg Log in to see 11至12个工作日
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大肠杆菌(E. Coli) His tag Validation with Western Blot 50 μg Log in to see 10至12个工作日
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酵母菌 大鼠 His tag   1 mg Log in to see 60至71个工作日
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酵母菌 Cow His tag   1 mg Log in to see 60至71个工作日
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酵母菌 野猪 His tag   1 mg Log in to see 60至71个工作日
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大肠杆菌(E. Coli) T7 tag,His tag   100 μg Log in to see 15至18个工作日
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大肠杆菌(E. Coli) 小鼠 非结合性   5 applications Log in to see 1至2个工作日
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FBXO32 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,
Mouse (Murine) ,

Rat (Rattus) ,

引用最多的FBXO32 蛋白

  1. Human FBXO32 Protein expressed in Wheat germ - ABIN1353808 : Lokireddy, McFarlane, Ge, Zhang, Sze, Sharma, Kambadur: Myostatin induces degradation of sarcomeric proteins through a Smad3 signaling mechanism during skeletal muscle wasting. in Molecular endocrinology (Baltimore, Md.) 2011 (PubMed)

更多F-Box Protein 32 (FBXO32)互动伙伴

Zebrafish F-Box Protein 32 (FBXO32) interaction partners

  1. Atrogin-1 inactivation leads to progressive impairment of heart and skeletal muscle function and structure. Autophagy is severely impaired in Atrogin-1-deficient zebrafish embryos.

Rainbow Trout (Oncorhynchus mykiss) F-Box Protein 32 (FBXO32) interaction partners

  1. Results suggest that the up-regulation of FBXO32 is associated with skeletal and smooth muscle atrophy that occurs during fasting.

Human F-Box Protein 32 (FBXO32) interaction partners

  1. FBXO32 activates NF-kappaB (显示 NFKB1 蛋白) through IkappaBalpha (显示 NFKBIA 蛋白) degradation in inflammatory and genotoxic stress

  2. Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase (显示 MUL1 蛋白) FBXO32/atrogin-1 and its transcription factor FOXO3A (显示 FOXO3 蛋白).

  3. Low FBXO32 expression is associated with breast cancer tumorigenesis.

  4. the involvement of oxidative stress in the atrophy of COPD peripheral muscle cells in vitro, via the FoxO1/MuRF1/atrogin-1 signaling pathway of the ubiquitin/proteasome system

  5. These results have revealed the roles for atrogin-1 in the regulation of smooth muscle contractility through enhancement of myocardin ubiquitylation/degradation and its transcriptional activity.

  6. Our results indicate that abnormal SCF (显示 KITLG 蛋白) activity with subsequent impairment of the autophagic flux due to a novel FBXO32 mutation is implicated in the pathogenesis of Dilated cardiomyopathy .

  7. Our data suggest that FBXO32 is a candidate gene for recessive familial dilated cardiomyopathy. Acting as a cardiac ubiquitin ligase, mutated FBXO32 could perturb the degradation of target proteins in the ubiquitin proteasome system.

  8. Vitamin D3 might have an inhibitory effect on the expression of MAFbx and MuRF1 (显示 TRIM63 蛋白) in skeletal muscle.

  9. Atrogin-1 expression tended to be increased in the skeletal muscle of patients with malignant disease even before c (显示 TNF 蛋白)ancer related cachexia weight loss.

  10. Expression of USP19 correlates with that of MuRF1 (显示 TRIM63 蛋白) and MAFbx/atrogin-1 in skeletal muscles

Pig (Porcine) F-Box Protein 32 (FBXO32) interaction partners

  1. this study shows that aspartate suppresses lipopolysaccharide-induced MAFbx expression in skeletal muscle via activation of Akt (显示 AKT1 蛋白) signaling, and inhibition of AMPKa and FOXO1 (显示 FOXO1 蛋白) signaling

  2. Porcine congenital splayleg (PCS) is a condition characterized by extensive fibre atrophy and raised fibre density. The combined differential expression of MAFbx and P311 (显示 C5orf13 蛋白) is of potential in the diagnosis of subclinical PCS.

Cow (Bovine) F-Box Protein 32 (FBXO32) interaction partners

  1. A study on the variability of bovine FBXO32 gene that is predictive of genetic potential for body length phenotype.

Mouse (Murine) F-Box Protein 32 (FBXO32) interaction partners

  1. Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase (显示 MUL1 蛋白) FBXO32/atrogin-1 and its transcription factor FOXO3A (显示 FOXO3 蛋白).

  2. Valproic acid attenuated muscle wasting and myotube atrophy and reduced C/EBPbeta (显示 CEBPB 蛋白) binding to atrogin1 promoter locus in the myotubes.

  3. These results have revealed the roles for atrogin-1 in the regulation of smooth muscle contractility through enhancement of myocardin ubiquitylation/degradation and its transcriptional activity.

  4. educed PABPN1 levels caused a consistent decline in distal PAS utilization in the 3'-UTR of a subset of OPMD-dysregulated genes. This alternative PAS utilization led to up-regulation of Atrogin-1, a key muscle atrophy regulator, but down regulation of proteasomal genes. Additionally reduced PABPN1 levels caused a reduction in proteasomal activity, and transition in MyHC isotope expression pattern in myofibers.

  5. Iron-induced skeletal muscle atrophy is suggested to involve the E3 ubiquitin ligase (显示 MUL1 蛋白) mediated by the reduction of Akt (显示 AKT1 蛋白)-FOXO3a (显示 FOXO3 蛋白) signaling by oxidative stress.

  6. MAFbx mRNA expression was decreased in old mice relative to adult mice, whereas MuRF1 (显示 TRIM63 蛋白) mRNA expression was less affected by ageing

  7. Suggest role for atrogin-1 up-regulation in simvastatin-induced heart mitochondria dysfunction.

  8. Atrogin1 was upregulated in cancer cachexia mice. Atrogin1 knockdown protected skeletal muscle cells from TNF-alpha (显示 TNF 蛋白) induced atrophy.

  9. Expression of USP19 correlates with that of MuRF1 (显示 TRIM63 蛋白) and MAFbx/atrogin-1 in skeletal muscles

  10. MAFbx not only regulates protein degradation, but also reduces protein synthesis, exerting a dual role in regulating cardiac mass and preventing from cardiac hypertrophy.

蛋白简介FBXO32

蛋白简介

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with F-Box Protein 32 蛋白 (FBXO32)

  • F-box protein 32 (fbxo32)
  • F-box protein 32 (FBXO32)
  • F-box protein 32 (Fbxo32)
  • 4833442G10Rik 蛋白
  • AI430017 蛋白
  • Atrogin1 蛋白
  • Fbx32 蛋白
  • Gm20361 蛋白
  • MAFbx 蛋白
  • MGC56479 蛋白
  • zgc:56479 蛋白

Protein level used designations for F-Box Protein 32 蛋白 (FBXO32)

F-box only protein 32 , atrogin-1 , F-box protein 32 , F-box only protein 32-like , atrogin 1 , muscle atrophy F-box protein , atrophy gene 1

GENE ID SPECIES
393891 Danio rerio
420343 Gallus gallus
464371 Pan troglodytes
475091 Canis lupus familiaris
704804 Macaca mulatta
100026040 Monodelphis domestica
100057506 Equus caballus
100142676 Ovis aries
100356177 Oryctolagus cuniculus
100387690 Callithrix jacchus
100462679 Salmo salar
100499214 Oncorhynchus mykiss
100580109 Nomascus leucogenys
114907 Homo sapiens
733657 Sus scrofa
513776 Bos taurus
67731 Mus musculus
171043 Rattus norvegicus
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