Elastase, Neutrophil Expressed 蛋白 (ELANE)

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. 再加上,我们可以发Elastase, Neutrophil Expressed 抗体 (168)Elastase, Neutrophil Expressed 试剂盒 (98)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
ELANE 1991 P08246
ELANE 50701 Q3UP87
大鼠 ELANE ELANE 299606  

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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 68至72个工作日
¥136,777.64
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 68至72个工作日
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HOST_Human 非结合性 10 μg Log in to see 24至29个工作日
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大肠杆菌(E. Coli) His tag,GST tag 100 μg Log in to see 9至12个工作日
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小麦胚 GST tag 10 μg Log in to see 29至34个工作日
¥2,963.90
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HOST_Human 非结合性   1 mg Log in to see 24至29个工作日
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HOST_Human 非结合性   200 μg Log in to see 24至29个工作日
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人细胞 非结合性   25 μg Log in to see 29至34个工作日
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非结合性   0.5 mg Log in to see 24至29个工作日
¥1,684.43
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大肠杆菌(E. Coli) 非结合性   100 μg Log in to see 29至40个工作日
¥6,185.81
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ELANE 蛋白 by Origin and Source

Origin 在表达 标记
Human , , , ,
, ,
Mouse (Murine)

引用最多的Elastase, Neutrophil Expressed 蛋白

  1. Human ELANE Protein expressed in Human - ABIN2544352 : Luyendyk, Shaw, Green, Maddox, Ganey, Roth: Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine. in The Journal of pharmacology and experimental therapeutics 2005 (PubMed)

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Human Elastase, Neutrophil Expressed (ELANE) interaction partners

  1. Data suggest that neuropilin-1 (NRP1 (显示 NRP1 蛋白)) functions as a receptor for neutrophil elastase (NE), mediates uptake/absorption of NE, and facilitates cross-presentation of PR1 (显示 TMEM37 蛋白) (a peptide fragment of NE) in breast cancer cells.

  2. This study proposes that acquisition of CSF3R (显示 CSF3R 蛋白) mutations may represent a mechanism by which myeloid precursor cells carrying the ELANE mutations evade the proapoptotic activity of the Neutrophil Elastase mutants in SCN (显示 SRI 蛋白) patients.

  3. Faecal biomarkers lactoferrin (显示 LTF 蛋白), calprotectin (显示 S100A8 蛋白), and PMN-elastase were able to distinguish between ulcerative colitis patients with mucosal healing from clinical remission and mild disease, showed significant correlations with endoscopy, and were predictive of a flare.

  4. In conclusion, site-specific CBG (显示 SERPINA6 蛋白) N-glycosylation regulates the bioavailability of cortisol in inflamed environments by fine-tuning the RCL (显示 C6orf108 蛋白) proteolysis by endogenous and exogenous elastases.

  5. Although circulating nucleosomes and elastase - alpha 1-antitrypsin (显示 SERPINA1 蛋白) complexes are at present the best characterized biomarkers for neutrophil extracellular traps formation and neutrophil activation, their lack of association with rs2288904 genotype does not exclude a role for SLC44A2 (显示 SLC44A2 蛋白) in neutrophil activation (and possibly NET formation) in Venous Thromboembolism.

  6. The levels of both NE and PR3 correlated with absolute neutrophil counts and are reduced in type 1 diabetes mellitus patients.

  7. The results of the present study may indicate that NE activates the phosphoinositide-3 kinase/Akt (显示 AKT1 蛋白) signaling pathway in leukemia cells to inhibit apoptosis and enhance cell proliferation

  8. The HNE-TACE signalling pathway has an important role in the process of MUC5AC overexpression in chronic rhinosinusitis.

  9. An increased NE: A1 AT ratio is closely associated with liver Inflammation in patients with NASH (显示 SAMSN1 蛋白) and could serve as a novel marker to predict NASH (显示 SAMSN1 蛋白) in humans

  10. Neutrophil elastase activity is deleterious for airway epithelial cell homeostasis.

Mouse (Murine) Elastase, Neutrophil Expressed (ELANE) interaction partners

  1. Levels of neutrophil elastase (NE) and the nuclear factors CCAAT/enhancer-binding protein alpha (C/EBPalpha (显示 CEBPA 蛋白)) and growth factor-independent 1 (GFI-1) are elevated in hematopoietic stem and progenitor cells from high-fat diet (HFD)-fed mice, but mice lacking either NE or C/EBPalpha (显示 CEBPA 蛋白) are resistant to HFD-induced myelopoiesis.

  2. Sivelestat treatment significantly reduced the protein level, neutrophil count, neutrophil elastase activity in bronchoalveolar lavage fluid (BALF).

  3. Serine protease (显示 F2 蛋白) required for resistance to microbial infection; contributes to pathogenessis in endotoxic shock

  4. Neutrophils from neutrophil elastase-deficient mice show no defect in transendothelial migration

  5. results of ultrasound studies using the elastase and AngII apoE (显示 APOE 蛋白) in 4 biomechanical parameters: aneurysm diameter, aneurysm volume, circumferential cyclic strain, and blood flow velocity

  6. Sirtinol is a novel HNE inhibitor and may have the potential for clinical application in the treatment of inflammatory lung diseases.

  7. SerpinA3N (显示 SERPINA3N 蛋白) attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase

  8. Increased ELANE activity was associated with development of autoimmune diabetes mellitus in NOD mice.

  9. Neutrophil elastase is involved in the induction of microbicidal activities of neutrophils against Trypanosoma cruzi-infected macrophages.

  10. In conclusion, sivelestat reduced radiationinduced lung injury in the mice by suppressing neutrophil elastase activity and excessive inflammatory reactions

蛋白简介Elastase, Neutrophil Expressed (ELANE)

蛋白简介

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.

Gene names and symbols associated with ELANE

  • proteinase 3 (prtn3)
  • elastase, neutrophil expressed (ELANE)
  • chymotrypsin-like elastase family, member 2A (CELA2A)
  • elastase, neutrophil expressed (Elane)
  • neutrophil elastase-like (LOC100522182)
  • Ela2 蛋白
  • ELANE 蛋白
  • F430011M15Rik 蛋白
  • GE 蛋白
  • HLE 蛋白
  • HNE 蛋白
  • NE 蛋白
  • PMN-E 蛋白
  • SCN1 蛋白

Protein level used designations for ELANE

elastase 2, neutrophil , neutrophil elastase , elastase, neutrophil expressed , chymotrypsin-like elastase family member 2A , elastase-2 , elastase-2A , pancreatic elastase II , PMN elastase , bone marrow serine protease , granulocyte-derived elastase , human leukocyte elastase , leukocyte elastase , medullasin , polymorphonuclear elastase , serine protease

GENE ID SPECIES
448597 Xenopus (Silurana) tropicalis
721134 Macaca mulatta
749897 Pan troglodytes
100301482 Felis catus
397197 Sus scrofa
1991 Homo sapiens
50701 Mus musculus
299606 Rattus norvegicus
442980 Canis lupus familiaris
100724414 Cavia porcellus
100126050 Bos taurus
100522182 Sus scrofa
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