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ELANE 蛋白

(Elastase, Neutrophil Expressed (ELANE))
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009].
ELANE Protein (AA 168-267) (GST tag) ELANE Protein (AA 168-267) (GST tag) ELANE Protein (AA 168-267) (GST tag) (ABIN1352646)

ELANE 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP

ELANE Protein (AA 30-267) (His tag) ELANE Protein (AA 30-267) (His tag) ELANE Protein (AA 30-267) (His tag) (ABIN3079274)

Crystallography grade ELANE 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys

ELANE Protein (AA 27-265) (His tag) ELANE Protein (AA 27-265) (His tag) ELANE Protein (AA 27-265) (His tag) (ABIN3122112)

Crystallography grade ELANE 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys

ELANE 蛋白 by Grade

Find ELANE 蛋白 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

ELANE 蛋白 by Origin

Find ELANE 蛋白 for a variety of species such as anti-Human ELANE, anti-Mouse ELANE, anti-Dog ELANE. The species listed below are among those available. Click on a link to go to the corresponding products.

ELANE 蛋白 by Source

Here you will find ELANE 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

ELANE 蛋白 by 蛋白类型

Here you can find ELANE 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

ELANE 蛋白 by 应用范围

Find ELANE 蛋白 validated for a specific application such as SDS, WB, Imm, PC. Some of the available applications are listed below. Click on a link to go to the corresponding products.

ELANE 蛋白 by 生物活性

Find ELANE 蛋白 with a specific 生物活性. The 生物活性 listed below are among those available. Click on a link to go to the corresponding products.

Popular ELANE 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1352646
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3079274
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3122112
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7389194
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7424920
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source
Validations
Cat. No. ABIN1048116
Quantity 100 μg
Datasheet Datasheet
Reactivity Dog
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7389191
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7389200
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Human
Validations
Cat. No. ABIN7507609
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7389197
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5709463
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Yeast
Validations
  • (1)
Cat. No. ABIN5713426
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN6238750
Quantity 50 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN6122495
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN6122499
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our ELANE 蛋白

Bolatchiev, Baturin, Bazikov, Maltsev, Kunitsina: "Effect of antimicrobial peptides HNP-1 and hBD-1 on Staphylococcus aureus strains in vitro and in vivo." in: Fundamental & clinical pharmacology, Vol. 34, Issue 1, pp. 102-108, (2020) (PubMed).

Luyendyk, Shaw, Green, Maddox, Ganey, Roth: "Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine." in: The Journal of pharmacology and experimental therapeutics, Vol. 314, Issue 3, pp. 1023-31, (2005) (PubMed).

Aliases for ELANE 蛋白

elastase, neutrophil expressed (ELANE) 蛋白
elastase, neutrophil expressed (Elane) 蛋白
proteinase 3 (prtn3) 蛋白
ELA2 蛋白
Ela2 蛋白
ela2 蛋白
ELANE 蛋白
F430011M15Rik 蛋白
GE 蛋白
HLE 蛋白
HNE 蛋白
NE 蛋白
PMN-E 蛋白
SCN1 蛋白
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